HHV-6 University

http://onlinelibrary.wiley.com/doi/10.1111/j.1348-0421.2007.tb03996.x/pdf

http://hhv-6foundation.org/news/humanized-mouse-model-demonstrates-hhv-6a-infection-can-cause-significant-immune-dysfunction

 http://www.ncbi.nlm.nih.gov/pubmed/24006442 J Virol. 2013 Nov;87(22):12020-8. doi: 10.1128/JVI.01556-13. Epub 2013 Sep 4. Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2-/-γc-/- Mice. Tanner A , Carlson SA , Nukui M , Murphy EA , Berges BK . Source Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah, USA. Abstract Although serious human diseases have been correlated with human herpesvirus 6A (HHV-6A) and HHV-6B, the lack of animal models has prevented studies which would more definitively link these viral infections to disease. HHV-6A and HHV-6B have recently been classified as two distinct viruses, and in this study we focused specifically on developing an in vivo model for HHV-6A. Here we show that Rag2(-/-)γc(-/-) mice humanized with cord blood-derived human hematopoietic stem cells produce human T cells that express the major HHV-6A receptor, CD46. Both cell-associated and cell-free viral ...

http://archinte.jamanetwork.com/article.aspx?articleid=617124&resultClick=1

http://www.hindawi.com/journals/tswj/2013/867389/