Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections. http://www.ncbi.nlm.nih.gov/pubmed/25762531 Clin Microbiol Rev. 2015 Apr;28(2):313-335. Agut H 1 , Bonnafous P 2 , Gautheret-Dejean A 3 . Abstract Human herpesvirus 6 (HHV-6) is a widespread betaherpesvirus which is genetically related to human cytomegalovirus (HCMV) and now encompasses two different species: HHV-6A and HHV-6B. HHV-6 exhibits a wide cell tropism in vivo and, like other herpesviruses, induces a lifelong latent infection in humans. As a noticeable difference with respect to other human herpesviruses , genomic HHV-6 DNA is covalently integrated into the subtelomeric region of cell chromosomes (ciHHV-6) in about 1% of the general population. Although it is infrequent, this may be a confounding factor for the diagnosis of active viral infection. The diagnosis of HHV-6 infection is performed by both serologic and direct methods. The most prominent technique is the quantific...