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Friday, June 21, 2013

Jay Levy on HHV-6

Characterization of a new strain of HHV-6 (HHV-6SF) Recovered from the saliva of an HIV-infected individual

Jay A. Levy, Frank Ferroa, Evelyne T. Lennette, Lyndon Oshiro and Louise Poulin

Abstract

An isolate of the human herpesvirus-6 (HHV-6SF) recovered from the saliva of an HIV-infected individual differs in its cellular host range and certain genomic properties from other HHV-6 strains described. HHV-6SF replicates in adult peripheral blood mononuclear cells (PMC) substantially better than in fetal cord blood PMC and can be grown only in the MT-4 established T cell line. It preferentially infects CD4+ lymphocytes but can replicate in CD8+ cells and peripheral blood macrophages. It also infects neuroblastoma cells and cell lines derived from the gastrointestinal tract. These latter results suggest that this herpesvirus could play a role in disorders affecting these tissues. Finally, the restriction enzyme pattern of HHV-6SF differs from that of other HHV-6 strains. The identification of this distinct HHV-6 strain could indicate an unusual biologic variation among viral isolates thus far not observed with other herpesviruses.
Virology, Volume 178, Issue 1, September 1990, Pages 113-121

Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections

http://www.neurology.org/content/61/10/1405.abstract


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