books on kindle

Saturday, December 07, 2019

GDF-15 may be a new dramatic link between Chronic Fatigue Syndrome and AIDS

GDF-15 may be useful biomarkers of CV risk and overall mortality in HIV infection.

Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome.

J Transl Med. 2019 Dec 4;17(1):409. doi: 10.1186/s12967-019-02153-6.
Circulating levels of GDF15 in patients with myalgic
encephalomyelitis/chronic fatigue syndrome.
Melvin A, Lacerda E, Dockrell HM, O'Rahilly S, Nacul L.


BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome
(ME/CFS) is a debilitating condition characterised by fatigue and
post-exertional malaise. Its pathogenesis is poorly understood. GDF15
is a circulating protein secreted by cells in response to a variety of
stressors. The receptor for GDF15 is expressed in the brain, where its
activation results in a range of responses. Among the conditions in
which circulating GDF15 levels are highly elevated are mitochondrial
disorders, where early skeletal muscle fatigue is a key symptom. We
hypothesised that GDF15 may represent a marker of cellular stress in

METHODS: GDF15 was measured in serum from patients with ME/CFS (n =
150; 100 with mild/moderate and 50 with severe symptoms), "healthy
volunteers" (n = 150) and a cohort of patients with multiple sclerosis
(n = 50).

RESULTS: Circulating GDF15 remained stable in a subset of ME/CFS
patients when sampled on two occasions ~ 7 months (IQR 6.7-8.8) apart,
720 pg/ml (95% CI 625-816) vs 670 pg/ml (95% CI 598-796), P = 0.5.
GDF15 levels were 491 pg/ml in controls (95% CI 429-553), 546 pg/ml
(95% CI 478-614) in MS patients, 560 pg/ml (95% CI 502-617) in
mild/moderate ME/CFS patients and 602 pg/ml (95% CI 531-674) in
severely affected ME/CFS patients. Accounting for potential
confounders, severely affected ME/CFS patients had GDF15
concentrations that were significantly increased compared to healthy
controls (P = 0.01). GDF15 levels were positively correlated (P =
0.026) with fatigue scores in ME/CFS.

CONCLUSIONS: Severe ME/CFS is associated with increased levels of
GDF15, a circulating biomarker of cellular stress that appears which
stable over several months.

Three Big Books

Two books on amazon

Everyone needs to know what the CDC is hiding about CFS and HHV-6. NEW YORK NATIVE contains both volumes of THE CHRONIC FATIGUE SYNDROME EPIDEMIC COVER-UP. The print version is $23. Only $7.98 in Kindle.

Popular Posts in the Last 7 Days

Our books on Amazon that are changing the way the world looks at CFS, HHV-6, and AIDS

Blog Archive

You can support us by listening to these songs by Charles Ortleb on Spotify.

Closing Argument Audible

African Swine Fever Novel Audible

Stonewall Audible