Three Big Books

Tuesday, June 02, 2020

Scientists warn that HHV-6 reactivation may be an issue in Covid-19


The Clinics of HHV-6 Infection in COVID-19 Pandemic: Pityriasis Rosea and Kawasaki Disease 

Abstract


A new type of coronavirus family (SARS-CoV-2), which can be found in humans and animals, with many varieties and clinical symptoms, was first seen in Wuhan, China in late 2019, under the name novel Coronavirus Disease 2019 (COVID-19). In the literature, cutaneous symptoms related to the disease are generally emphasized. However, it is not yet known whether this new SARS-CoV-2 virus, which has entered our lives, plays a role in the etiopathogenesis of dermatological diseases. The patients who were admitted to the dermatology outpatient clinic between 1 April and May 15, 2019, and on 1 April and May 15, 2020 were retrospectively analyzed by searching the hospital automation system and patient files. The reason for the same months to be included in the study was to exclude seasonal effects on the diseases. After pandemic, the number of patients with Pityriasis rosea and Kawasaki disease increased significantly in patients who applied to the dermatology outpatient clinic. Our study is the first study showing pityriasis rosea increase during the pandemic period. We think that this increase is related to HHV-6 reactivation. Herein, we wanted to draw attention to two diseases in which Human Herpes 6 (HHV-6) was accused in etiopathogenesis: Kawasaki disease and Pityriasis rosea

Source:
https://pubmed.ncbi.nlm.nih.gov/32475003/

Sunday, May 31, 2020

Scientists raise questions about study that tried to bury hydroxychloroquine.


Scientists Question Validity of Major Hydroxychloroquine Study

https://www.nytimes.com/2020/05/29/health/coronavirus-hydroxychloroquine.html?algo=identity&fellback=false&imp_id=409512581&action=click&module=Science%20%20Technology&pgtype=Homepage

The antimalarial drug hydroxychloroquine has shown mixed results against the coronavirus in early studies, but a new paper out of New York suggests combining it with the dietary supplement zinc sulfate could create a more effective treatment. 



Can Covid-19 be transmitted by animal fur?


While there exists a possibility that household pets can become infected with coronavirus (albeit a low one), to what extent can pet fur or skin be a transmission route for viral infection to a human?


http://www.digitaljournal.com/tech-and-science/science/can-the-novel-coronavirus-be-transmitted-on-animal-fur/article/572490


South Africa urges social distancing for pigs in African Swine Fever epidemic.

The SA govt now suggests social distancing for pigs, as African swine fever spreads
  • The agriculture department is recommending a form of social distancing for South Africa's pigs.
  • African swine fever has now also been detected in the Free State, and may be spreading fast in the Eastern Cape.

https://www.businessinsider.co.za/african-swine-fever-requires-social-distancing-for-pigs-2020-5


Scientists are looking for coinfections in Covid-19. Will African Swine Fever turn out to be one of them?



https://www.covid-coinfections.org/t/cosmic-co-infections-and-secondary-microbial-infections-in-covid-19/17

Thursday, May 28, 2020

NIH director: ‘No way of knowing’ if coronavirus escaped from Wuhan lab

https://www.politico.com/news/2020/05/27/nih-director-wuhan-coronavirus-collins-285681



 Report says cellphone data suggests October shutdown at Wuhan lab, but experts are skeptical

A private analysis of cellphone location data purports to show that a high-security Wuhan laboratory studying coronaviruses shut down in October, three sources briefed on the matter told NBC News. U.S. spy agencies are reviewing the document, but intelligence analysts examined and couldn't confirm a similar theory previously, two senior officials say.
The report — obtained by the London-based NBC News Verification Unit — says there was no cellphone activity in a high-security portion of the Wuhan Institute of Virology from Oct. 7 through Oct. 24, 2019, and that there may have been a "hazardous event" sometime between Oct. 6 and Oct. 11.
Source:
https://news.yahoo.com/report-says-cellphone-data-suggests-001233644.html?.tsrc=daily_mail&uh_test=2_15


Re: FREEDOM OF INFORMATION ACT REQUEST OF THE NATIONAL LEGAL AND POLICY CENTER- RE: NIAID GRANTS TO WUHAN INSTITUTE OF VIROLOGY REGARDING CORONAVIRUS EXPERIMENTS AND RELATED RECORDS


Dear Ms. Schofield:

            Pursuant to the Freedom of Information Act (FOIA), 5 USC 552, et seq. and Health and Human Services (HHS) FOIA regulations, 45 C.F.R. Part 5, the National Legal and Policy Center (NLPC) hereby requests the release of the following records: any and all grants and funding given by the National Institute of Allergy and Infectious Diseases (NIAID) to the Wuhan Institute of Virology (WIV) in Wuhan, China or through other grantees including EcoHealth Alliance from 2014 to the present, including a $3.7 million grant given on or about 2015, for coronavirus experiments including those on mammals and bats, and all documents related to those grants, including but not limited to applications for the grants, studies, reports, audits, lab inspections, correspondence, memoranda, cables, and all emails to or from Anthony S. Fauci, M.D., the Director of NIAID related to the, including the recent decision by the Trump Administration to terminate such funding. 

NLPC also requests all documents, including memoranda, correspondence, and emails, to or from Dr. Fauci from December 1, 2019 to the present from or to the Wuhan Institute of Virology, EcoHealth Alliance, the World Health Organization (WHO), the Centers for Disease Control and Prevention (CDC), Deborah H. Birx, M.D., U.S. Special Representative for Global Health Diplomacy-Department of State, or any employee of those agencies including NIAID, that refer to the novel coronavirus and COVID-19, the Wuhan Institute of Virology, the epicenter of the coronavirus and its outbreak in Wuhan, China, and the coverup by China and WHO for failing to fully and timely disclose information on the extent of the novel coronavirus outbreak in Wuhan, China that led to a worldwide pandemic.
SOURCE:
https://nlpc.org/2020/04/28/nlpc-seeks-niaid-documents-regarding-wuhan-lab-and-pandemic/

Fauci again dismisses conspiracy theory that the coronavirus was made in a Wuhan lab after Pompeo touted 'enormous evidence' of a cover-up
https://www.businessinsider.com/fauci-denies-wuhan-lab-conspiracy-theories-national-geographic-interview-2020-5

 "China deliberately suppressed or destroyed evidence of the coronavirus outbreak in an “assault on international transparency’’ that cost tens of thousands of lives, according to a dossier prepared by concerned Western governments on the COVID-19 contagion." 

Source: 
https://www.dailytelegraph.com.au/coronavirus/bombshell-dossier-lays-out-case-against-chinese-bat-virus-program/news-story/55add857058731c9c71c0e96ad17da60


  • President Donald Trump said at a Fox News town hall on Sunday night that "everybody," including leading infectious disease expert Dr. Anthony Fauci, previously downplayed the severity of the virus. 
  • In response to a question about why he did not act sooner to prepare for a COVID-19 outbreak in the US, Trump said Fauci "was saying it's gonna pass, not gonna be a big deal."
Source:
https://www.msn.com/en-us/news/politics/trump-defends-the-uss-bungled-coronavirus-response-by-claiming-fauci-told-him-its-not-gonna-be-a-big-deal/ar-BB13ypGd?ocid=spartanntp

"United States Secretary of State Mike Pompeo said there's "enormous evidence" that COVID-19 originated in a lab in Wuhan, China, and the Chinese government went to great lengths to intentionally conceal the severity of the outbreak."
Source: Newsweek
https://www.newsweek.com/mike-pompeo-confirms-china-sought-cover-covid-19-severity-enormous-evidence-virus-originated-1501661

Trump's strategy of blaming China for COVID-19 may end up pointing the finger at Fauci. Politico: "The strategy to blame China for the coronavirus outbreak began weeks ago in Washington, D.C. Now it’s spread to the rest of the country."




https://www.politico.com/news/2020/05/03/trump-supporters-china-226309

Rudy Giuliani raises questions about Fauci's Involvement with Wuhan lab that did bat/pig coronavirus experiments: "Back in 2014, the Obama administration prohibited the U.S. from giving any money to any laboratory, including in the U.S., that was fooling around with these viruses. Prohibited! Despite that, Dr. Fauci gave $3.7 million to the Wuhan laboratory — and then even after the State Department issued reports about how unsafe that laboratory was, and how suspicious they were in the way they were developing a virus that could be transmitted to humans," he claimed. He added, "We never pulled that money. So, something here is going on, John. I don’t want to make any accusations. But there was more knowledge about what was going on in China with our scientific people than they disclosed to us when this first came out. Just think of it: If this laboratory turns out to be the place where the virus came from, we paid for it. We paid for the damn virus that’s killing us.”

Source:






Washington Times raises questions about Fauci's links to Wuhan laboratory where coronavirus experiments were being conducted on bats and pigs.






https://www.washingtontimes.com/news/2020/apr/27/anthony-fauci-should-explain-37-million-wuhan-labo/

From the Sun:

Covid-19 was originally thought to have come from a so-called “wet market” in the Chinese city.

But there has been mounting speculation linking the disease to the lab, which is one of two in Wuhan, and a possible leak.

Scientists at WIV experimented on bats as part of a project funded by the US National Institutes of Health, which licences it to receive American money, the Mail on Sunday reports.

Research published in April 2018 probed the cross-species transmission of coronaviruses from bats, to other animals, and then to humans.

The study - titled "'fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin" - was investigating a bat-related coronavirus outbreak on Chinese pig farms.

Bats were captured in a cave and samples were taken from the creatures.

Scientists then grew the virus in a lab before injecting it into three-day-old piglets.

The sick animals were then killed and their intestines were ground up into a slurry and fed to other piglets.

Source:
https://www.thesun.co.uk/news/11392677/wuhan-coronavirus-scientists-bat-virus-injection-pig-cannibal/






Source:
https://nationalfile.com/faucis-niaid-funded-wuhan-lab-scientists-to-research-bat-coronavirus/

Congress needs to look at the bats and pigs experiments that Fauci may have helped finance in the Wuhan Laboratory.

Newsweek: Dr. Fauci Backed Controversial Wuhan Lab with Millions of U.S. Dollars for Risky Coronavirus Research

"In 2019, with the backing of NIAID, the National Institutes of Health committed $3.7 million over six years for research that included some gain-of-function work. The program followed another $3.7 million, 5-year project for collecting and studying bat coronaviruses, which ended in 2019, bringing the total to $7.4 million.
Many scientists have criticized gain of function research, which involves manipulating viruses in the lab to explore their potential for infecting humans, because it creates a risk of starting a pandemic from accidental release."

The Newsweek article:

https://www.newsweek.com/dr-fauci-backed-controversial-wuhan-lab-millions-us-dollars-risky-coronavirus-research-1500741

Tuesday, May 26, 2020

Are meat processors getting sick because pork is coming from pigs infected with the Covid-19 virus?


Meat industry is trying to get back to normal, but workers are still getting sick

https://www.houstonchronicle.com/news/article/Big-meat-processors-saw-plants-become-covid-19-15293690.php

Was Covid-19 the result of two coronaviruses mixing in pigs?



EXCLUSIVE: The coronavirus that has become a world-wide pandemic may have been created in a “cell-culture experiment” in a laboratory, according to prominent scientists who have conducted ground-breaking research into the origins of the virus.

https://www.skynews.com.au/details/_6158843835001

Doctors from NYU Langone Medical Center: Langone This study provides the first in vivo evidence that zinc sulfate in combination with hydroxychloroquine may play a role in therapeutic management for COVID-19.


Abstract:
Background: COVID-19 has rapidly emerged as a pandemic infection that has caused significant mortality and economic losses. Potential therapies and means of prophylaxis against COVID-19 are urgently needed to combat this novel infection. As a result of in vitro evidence suggesting zinc sulfate may be efficacious against COVID-19, our hospitals began using zinc sulfate as add-on therapy to hydroxychloroquine and azithromycin. We performed a retrospective observational study to compare hospital outcomes among patients who received hydroxychloroquine and azithromycin plus zinc versus hydroxychloroquine and azithromycin alone. Methods: Data was collected from electronic medical records for all patients being treated with admission dates ranging from March 2, 2020 through April 5, 2020. Initial clinical characteristics on presentation, medications given during the hospitalization, and hospital outcomes were recorded. Patients in the study were excluded if they were treated with other investigational medications. Results: The addition of zinc sulfate did not impact the length of hospitalization, duration of ventilation, or ICU duration. In univariate analyses, zinc sulfate increased the frequency of patients being discharged home, and decreased the need for ventilation, admission to the ICU, and mortality or transfer to hospice for patients who were never admitted to the ICU. After adjusting for the time at which zinc sulfate was added to our protocol, an increased frequency of being discharged home (OR 1.53, 95% CI 1.12-2.09) reduction in mortality or transfer to hospice remained significant (OR 0.449, 95% CI 0.271-0.744). Conclusion: This study provides the first in vivo evidence that zinc sulfate in combination with hydroxychloroquine may play a role in therapeutic management for COVID-19.

Source:
https://www.researchgate.net/publication/341254876_Hydroxychloroquine_and_azithromycin_plus_zinc_vs_hydroxychloroquine_and_azithromycin_alone_outcomes_in_hospitalized_COVID-19_patients

Monday, May 25, 2020

Is Chronic Fatigue Syndrome research funding being diverted to Covid-19?


Kawasaki-like syndrome in Covid-19 patients looks disturbingly like African Swine Fever


https://www.sciencedirect.com/topics/medicine-and-dentistry/african-swine-fever

Cats can harbor SARS-CoV-2 without symptoms. Can pigs? Is pork infected?

Study shows cats can harbor SARS-CoV-2 without any symptoms

https://www.news-medical.net/news/20200524/Study-shows-cats-can-harbor-SARS-CoV-2-without-any-symptoms.aspx


"Growing the virus in animal cells is one way to test whether the pathogen has adapted to a new host. Shi Yi, a microbiologist at the CAS Institute of Microbiology in Beijing, plans to introduce an inactivated version of RATG13, in various animals, such as bats, cats monkeys and pigs, and see whether the virus develops a similar pattern of mutations to SARS-CoV-2 over time. If similarities emerge, that could reveal which animals the virus adapted to before it jumped to people. "

https://www.nature.com/articles/d41586-020-01449-8

Why isn't China testing its pigs in Wuhan and Hubei for SARS-CoV-2? This experiment is beating around the bush.


"Growing the virus in animal cells is one way to test whether the pathogen has adapted to a new host. Shi Yi, a microbiologist at the CAS Institute of Microbiology in Beijing, plans to introduce an inactivated version of RATG13, in various animals, such as bats, cats monkeys and pigs, and see whether the virus develops a similar pattern of mutations to SARS-CoV-2 over time. If similarities emerge, that could reveal which animals the virus adapted to before it jumped to people. "

https://www.nature.com/articles/d41586-020-01449-8

Sunday, May 24, 2020

Scientists in Beijing are conducting experiments to see if pigs are the intermediate vector of the Covid-19 virus (SARS-CoV-2)


"Growing the virus in animal cells is one way to test whether the pathogen has adapted to a new host. Shi Yi, a microbiologist at the CAS Institute of Microbiology in Beijing, plans to introduce an inactivated version of RATG13, in various animals, such as bats, cats monkeys and pigs, and see whether the virus develops a similar pattern of mutations to SARS-CoV-2 over time. If similarities emerge, that could reveal which animals the virus adapted to before it jumped to people. "

https://www.nature.com/articles/d41586-020-01449-8

Friday, May 22, 2020

Are Mink with COVID-19 in Netherlands also infected with African Swine Fever Virus?


Mink in Netherlands are infected with the COVID-19 virus. Are they also infected with African Swine Fever Virus, which can infect mink? Is a novel strain of African Swine Fever now circulating in the Netherlands? Are pigs in the Netherlands infected with SARS-CoV-2?

Mink May Have  Infected a Human with Covid-19, Dutch Authorities Believe
https://www.msn.com/en-ca/news/world/minks-may-have-infected-a-human-with-covid-19-dutch-authorities-believe/ar-BB14mQeR

Susceptibility of Mink to Certain Viral Animal Diseases Foreign to the United States


Abstract

Mink (Mustela vison) were inoculated with viruses: African horse sickness (AHS), African swine fever (ASF), bovine herpes virus II (BHV2), foot-and-mouth disease (FMD), goat pox (GP), hog cholera (HC), peste des petits ruminants (PPR), rinderpest (RP), swine vesicular disease (SVD), vesicular exanthema of swine (VES) and vesicular stomatitis (VS). Their susceptibility was measured by development of clinical signs, virus isolation and detection of precipitin and/or virus neutralizing antibodies. SVD virus produced a lesion in one mink. Virus was isolated from mink inoculated with SVD, FMD and BHV2. Neutralizing and/or precipitin antibodies were detected in mink inoculated with ASF, FMD, GP, RP, SVD and VS viruses. Mink were not susceptible to AHS, HC, PPR and VES viruses. 



Long Before Covid-19, What was Happening All Over China?


Long before Covid-19 there was a disease all over China that destroyed the lungs.


Long before Covid-19 there was a disease all over China that caused fevers.


Long before Covid-19 there was a disease all over China that caused multisystemic inflammation.


Long before Covid-19 there was a disease all over China that caused a fatal cytokine storm.


Long before Covid-19 there was a disease all over China that caused vasculitis.


Long before Covid-19 there was a disease all over China that damages the heart.


Long before Covid-19 there was a disease all over China that damages the kidneys.


Long before Covid-19 there was a disease all over China that damages the liver.


Long before Covid-19 there was a disease all over China that affects the spleen.


Long before Covid-19 there was a disease all over China that affects the tonsils.


Long before Covid-19 there was a disease all over China that affects the lymph nodes.


Long before Covid-19 there was a disease all over China that caused hypoxia.


Long before Covid-19 there was a disease all over China that affected macrophages.


Long before Covid-19 there was a disease all over China that caused immune suppression.


Long before Covid-19 there was a disease all over China that resulted in multiple secondary infections.


Long before Covid-19 there was a disease all over China that affected the natural killer cells.


Long before Covid-19 there was a disease all over China that affected the dendritic cells.


Long before Covid-19 there was a disease all over China that affected the epithelial cells.


Long before Covid-19 there was a disease all over China that affected the CD4 cells.


Long before Covid-19 there was a disease all over China that caused rashes.


Long before Covid-19 there was a disease all over China that caused petechiae.


Long before Covid-19 there was a disease all over China that caused an elevation of IL-6, IL-10, TNF and IP-10.


Long before Covid-19 there was a disease all over China that caused thrombosis.


Long before Covid-19, that disease, which caused the loss of half of China’s four hundred million pigs, was African Swine Fever, the multisystemic inflammatory disease that strikes fear in the heart of every agricultural researcher and farmer all over the world. If SARS-CoV-2 had never been identified as the cause of Covid-19, African Swine Fever would have been the painfully obvious leading suspect. Is it still possible that African Swine Fever is a co-infection or cofactor in Covid-19? Why have scientists not looked for known and novel strains of African Swine Fever in Covid-19 patients? And given that millions of pigs throughout China had African Swine Fever with all the immunological destruction it causes, why hasn’t China considered the possibility that SARS-Cov-2 is just one of the many coinfections of immunologically-challenged pigs with African Swine Fever in Wuhan, Hubei, and the rest of China?


Anyone who says that people cannot become infected with African Swine Fever has only a partial knowledge of the science. They are not aware of all the public health warnings about the evolving nature of zoonotic diseases. In 2009, scientists discovered novel sequences related to African Swine Fever in human serum and sewage. In their abstract they concluded, “The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the asfarvirus family but highly divergent from ASFV. Detection of these sequences suggests that greater genetic diversity may exist among asfarviruses than previously thought and raises the possibility that human infection by asfarviruses may occur.” (Source)


Two recent questionable experiments involving Covid-19 and pigs really constitute “beating around the bush.” One experiment in Germany unsuccessfully tried to infect pigs with SARS-Cov-2 and another one in India projected that pigs could not be infected based on a computer model. Research that does not “beat around the bush” would simply test pigs for SARS-Cov-19. The first papers that came out about SARS-Cov-2 noted that pigs have ACE2 receptors, so it will not come as a surprise to at least some scientists if it turns out that pigs are intermediate vectors of SARS-Cov-2. (Source #1, Source #2) One study concluded, “Due to the large number of infected people  often with high virus loads, SARS-CoV-2 could potentially spill over in other species including pigs and this should be monitored closely.” (Source)


But the bigger issue with enormous public health consequences is the question of whether African Swine Fever virus is an unidentified cofactor or coinfection of SARS-Cov-2 in Covid-19. The more alarming question is whether SARS-Cov-2 is a secondary infection and the mysterious nature of the emerging epidemic is a mystery caused by a major paradigm mistake which is the result of blaming the wrong pathogen for our international medical crisis. Science goes down the wrong path all the time and courageously corrects itself. Could African Swine fever be the Black Swan of Covid-19? Are we due for a midcourse correction in our understanding of Covid-19?


If China will not test the pigs in Wuhan and Hubei for SARS-Cov-2, then perhaps scientists in Italy and the USA can step in. The area most affected by COVID-19 in northern Italy is densely populated by domestic pigs. And then there is the curious issue of the pork production facilities in the USA that are hotspots for COVID-19. Doesn’t prudence demand that pigs in those facilities be tested both for SARS-Cov-2 and novel strains of African Swine Fever?


Recent research has identified twenty-four respiratory coinfections in Covid-19 patients. Isn’t it time to make the search for coinfections and cofactors deeper and broader? Should Covid-19 patients be tested with something like the ViroChip for every known and possibly novel infection? Of course, it is possible that African Swine Fever has nothing to do with Covid-19. But in this evolving disaster, no stone should be left unturned. One thing is clear: Anyone who says that what happens pathologically in African Swine Fever and Covid-19 is not similar is just not paying attention.

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