© 2005 American Society for Investigative Pathology Human Herpesvirus 6 Activates Lytic Cycle Replication of Kaposi’s Sarcoma-Associated Herpesvirus Chun Lu * , Yi Zeng * , Zan Huang , Li Huang * , Chao Qian * , Guixia Tang * and Di Qin * From the Department of Microbiology and Immunology, * Laboratory of Molecular Virology, and the Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People’s Republic of China; and the Department of Cell Biology, Neurology, and Anatomy, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois Kaposi’s sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is a -herpesvirus consistently identified in Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman’s disease. KSHV infection appears to be necessary, but not be sufficient for development of KS without other co-fact...