A Summary of HHV-6's Destructivenss
From an article by Abdel-Haq NahedM, Asmar BasimI in The Indian Journal of Pediatrics (2004,Volume 71, Issue 1, Page 89-96) HHV-6 preferentially infects CD4+ T-lymphocytes;[17] but can also infect other cell lines of epithelial, fibroblastic and neuronal origins with different efficiency.[18],[19],[20] The surface marker CD46 acts as part of a co-receptor for infection by both HHV-6A and HHV-6B.[21] Although CD46 is expressed by most nucleated human cells and may explain the wide cellular tropism of HHV-6, the virus does not infect all CD46-positive cells. Following infection, HHV-6 persists and establishes latency in different cells and organs including monocytes/macrophages, salivary glands, the brain and the kidneys. Because the main target cells for infection are the CD4-positive lymphocytes and monocytes, HHV-6 infection has important effects on the immune system. These include enhancement of natural killer cells, inhibition of T-cell proliferation, induction of cytokine rel