HHV-6 infects human aortic and heart microvascular endothelial cells
J Med Virol. 2002 Aug;67(4):528-33. Related Articles,
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HHV-6 infects human aortic and heart microvascular
endothelial cells, increasing their ability to secrete
proinflammatory chemokines.
Caruso A, Rotola A, Comar M, Favilli F, Galvan M,
Tosetti M, Campello C, Caselli E, Alessandri G, Grassi
M, Garrafa E, Cassai E, Di Luca D.
Tosetti M, Campello C, Caselli E, Alessandri G, Grassi
M, Garrafa E, Cassai E, Di Luca D.
Institute of Microbiology, University of Brescia
Medical School, Italy.
Medical School, Italy.
Endothelial cells are important targets for
herpesvirus infection. To evaluate the biological
effects of human herpesvirus-6 (HHV-6) infection,
adult heart microvascular and aortic endothelial cells
were examined for in vitro susceptibility to HHV-6 and
for the alterations induced by viral infection on the
production of monocyte chemoattractant protein-1
(MCP-1) and interleukin-8 (IL-8). Analysis by reverse
transcription-polymerase chain reaction and by in situ
polymerase chain reaction showed that HHV-6 replicates
in endothelium in the absence of cytopathic effects,
and that viral sequences were present in 20% umbilical
vein and in 10% aortic and 1% microvascular
endothelium. HHV-6 infection upregulated the
production of MCP-1 and IL-8, with differences
observed between aortic and microvascular endothelium.
These findings demonstrate that endothelial cells
represent a potential reservoir for HHV-6 infection,
and the altered pattern of chemokine production can
lead to attraction of immunocompetent cells and to the
development of inflammatory processes.
herpesvirus infection. To evaluate the biological
effects of human herpesvirus-6 (HHV-6) infection,
adult heart microvascular and aortic endothelial cells
were examined for in vitro susceptibility to HHV-6 and
for the alterations induced by viral infection on the
production of monocyte chemoattractant protein-1
(MCP-1) and interleukin-8 (IL-8). Analysis by reverse
transcription-polymerase chain reaction and by in situ
polymerase chain reaction showed that HHV-6 replicates
in endothelium in the absence of cytopathic effects,
and that viral sequences were present in 20% umbilical
vein and in 10% aortic and 1% microvascular
endothelium. HHV-6 infection upregulated the
production of MCP-1 and IL-8, with differences
observed between aortic and microvascular endothelium.
These findings demonstrate that endothelial cells
represent a potential reservoir for HHV-6 infection,
and the altered pattern of chemokine production can
lead to attraction of immunocompetent cells and to the
development of inflammatory processes.
1. HIV is a massive scientific fraud. Something akin to a Ponzi scheme. Scientists who challenged the HIV theory of AIDS (the ones who have been thuggishly censored and silenced) turn out to be on the money.
2. Chronic Fatigue Syndrome and Autism (and many other so-called HHV-6 related mysterious epidemics) are part of the so-called AIDS epidemic. Chronic Fatigue Syndrome and Autism both are clearly the results of the ravages of HHV-6.
3. AIDS and Chronic Fatigue Syndrome has been artificially and politically separated into two epidemics. We are living in a period of CFS/AIDS apartheid. So-called AIDS patients have to sit in the back of the HHV-6 epidemic bus while the befuddled HHV-6/CFS patients and HHV-6/Autism victims sit up front. Nobody is well-served.
4. AIDS is not a sexually transmitted disease. That paradigm has set a scapegoating and antigay agenda in place that the public thinks is solidly based on science. It is only based on homophobic and racist nosology, epidemiology and virology. The scientists behind the paradigm are charlatans and crooks.
5. The Centers for Disease Control in Atlanta and the Pasteur Institute in Paris have a great deal in common with the institutions of Nazi medicine. For Blacks, everything these institutions have done in the name of AIDS really constitutes a second Tuskegee Syphilis Experiment.
Elements of a Scientific Ponzi Scheme like the Montagnier-Agut HIV Fraud Ponzi Scheme and HHV-6 Cover-up
A
scientific Ponzi scheme begins with a central seminal or foundational
scientific fraud and is sometimes built on an infrastructure of smaller
scientific frauds. Like the fake dividends issued in a strictly
financial Ponzi scheme, a scientific Ponzi scheme issues fake dividends
in the form of ongoing fraud-based research often framed as
"breakthroughs" and bogus extrapolations which make it look like
everything is above board and that what, in reality, is scientific
fraud, appears to the rest of the scientific community and the public as
good faith progress.
A classic scientific Ponzi scheme like the Montgnier-Agut HIV Fraud Ponzi Scheme and HHV-6 Cover-up include elements like these:
1. Nosological fraud.
2. Epidemiological fraud.
3. Virological fraud.
4. Treatment fraud.
5. Public health policy fraud.
6. Concealment of negative scientific data and paradigm-challenging anomalies.
7. Use of an elite network of "old boys" and pseudo-activist provocateurs to censor critics and whistleblowers.
8. Chronic obscurantism.
9.
If necessary, vigilantism and witch-hunts against any intellectuals,
scientists, or citizens who constitute any form of resistance to the
Ponzi scheme.
10. A subservient scientific press that is used as a conveyor belt for the Ponzi scheme's propaganda.
Everything
always looks like it is working perfectly in a Ponzi scheme, until the
moment comes when someone look at the books and blows the whistle.
Hopefully, that game-changing moment for the Montagnier-Agut HIV Fraud
Ponzi Scheme and HHV-6 Cover-up is coming soon.
