Steve Jacobson on HHV-6

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Human herpesvirus-6 entry into the central nervous system through the olfactory pathway

Abstract

Viruses have been implicated in the development of neurodegenerative diseases, such as Alzheimer's, Parkinson’s, and multiple sclerosis. Human herpesvirus-6 (HHV-6) is a neurotropic virus that has been associated with a wide variety of neurologic disorders, including encephalitis, mesial temporal lobe epilepsy, and multiple sclerosis. Currently, the route of HHV-6 entry into the CNS is unknown. Using autopsy specimens, we found that the frequency of HHV-6 DNA in the olfactory bulb/tract region was among the highest in the brain regions examined. Given this finding, we investigated whether HHV-6 may infect the CNS via the olfactory pathway. HHV-6 DNA was detected in a total of 52 of 126 (41.3%) nasal mucous samples, showing the nasal cavity is a reservoir for HHV-6. Furthermore, specialized olfactory-ensheathing glial cells located in the nasal cavity were demonstrated to support HHV-6 replication in vitro. Collectively, these results support HHV-6 utilization of the olfactory pathway as a route of entry into the CNS.
Erin Harbertsa
Karen Yaoa
Jillian E. Wohlera,
Dragan Maricc,
Joan Ohayona,
Robert Henkind, and
Steven Jacobson
Edited by Robert C. Gallo, Institute of Human Virology, University of Maryland, Baltimore, Baltimore, MD,
http://www.pnas.org/content/early/2011/08/01/1105143108.abstract
"Virologist Dharam Ablashi, who codiscovered HHV-6 and now is scientific director of the HHV-6 Foundation in Santa Barbara, Calif., says the results may be just the tip of an iceberg. 'As research techniques improve,' he says, 'we may find that most neurological conditions are caused by viruses that enter the brain through the nasal passages.'"
http://www.sciencenews.org/view/generic/id/333083/title/Commonvirusmayrideupnoseto_brain

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https://www.facebook.com/CFSDocumentary/photos/a.584129808284545.1073741828.572661299431396/962762227087966/?type=1&theater http://www.theguardian.com/world/2015/jun/02/lgbt-people-suffer-widespread-violent-abuse-discrimination-new-un-report If HHV-6 is the real cause of AIDS, here are some of the implications: 1. HIV is a massive scientific fraud. Something akin to a Ponzi scheme. Scientists who challenged the HIV theory of AIDS (the ones who have been thuggishly censored and silenced) turn out to be on the money. 2. Chronic Fatigue Syndrome and Autism (and many other so-called HHV-6 related mysterious epidemics) are part of the so-called AIDS epidemic.  Chronic Fatigue Syndrome and Autism both are clearly the results of the ravages of HHV-6. 3. AIDS and Chronic Fatigue Syndrome has been artificially and politically separated into two epidemics. We are living in a period of CFS/AIDS apartheid. So-called AIDS patients have to sit in the back of the HHV-6...
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https://www.researchgate.net/publication/258104443_Immunomodulation_and_immunosuppression_by_human_herpesvirus_6A_and_6B Please send an email to Dr. Francis Collins, the Director of the National Institutes of Health. Francis.Collins@nih.hhs.gov Francis S. Collins Director of the National Institutes of Health  9000 Rockville Pike Bethesda, Maryland 20892 Dear Dr. Collins: It's time that the public knew about all the diseases HHV-6 is causing in our society. The days of using the fraudulent HIV paradigm of AIDS to cover up the HHV-6 pandemic must come to an end! You shouldn't try to control panic about HHV-6 by lying to the public. I urge you to support the goals of International HHV-6 Protests and Teach-ins that will be taking place at universities all over the world during the next several years. Those goals include the support of freedom of thought, speech and dissent in science in general and in research of HHV-6-related diseases in ...
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http://hhv-6foundation.org/category/animal-models The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of ASFV in Heart Disease. 10. The right not to be lied to about the role of ASFV in Encephalitis. 11. T...
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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
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From Perplexity A.I.: A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences.

-
  A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences. Scale and Impact of AIDS The way AIDS was defined and classified determined how millions of people were diagnosed, treated, and socially perceived. Nosological mistakes have led to unnecessary suffering, stigmatization, discrimination, and sometimes fatal outcomes for entire populations. During the early epidemic, AIDS definitions dictated global policies, resource allocation, and public health strategies, impacting the lives of marginalized groups and shaping health systems globally. Misdirected Interventions and Suffering If the nosology—such as equating all immune compromise with AIDS or failing to recognize other causes—was incorrect, countless lives may have been lost or damaged due to misdiagnosis, inappropriate tre...
Read more

Perplexity on K.S. and AIDS and inflammation

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Read more

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  The distinction between endogenous and exogenous retroviruses is often presented as a clear-cut biological fact, but making this determination is not always straightforward—and some arguments support the view that political, institutional, and even social factors play a significant role in where and how the line is drawn. Reasons why this classification can be political and is not always clear-cut: Definition Complexity: Endogenous retroviruses (ERVs) are viral sequences embedded in the germline DNA, inherited across generations, and mainly considered “old,” non-infectious remnants. Exogenous retroviruses are “external” viruses that infect individuals horizontally (from person to person or animal to animal). Yet, both are often nearly indistinguishable at the genetic level—sometimes a retrovirus can exist as both, or transition between the two categories over evolutionary time. Intermediate and Ambiguous Cases: Evidence suggests certain viruses classified as endogenous today were...
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Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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HHV-6 and Male infertility (from Perplexity)

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  Make the case that HHV-6 may be responsible for the fertility problems in men Make the case that HHV-6 may be responsible for the fertility problems in men There is a growing body of evidence suggesting that Human Herpesvirus 6 (HHV-6) may play a role in male fertility problems. Here is the case based on recent research findings: Prevalence in Semen and Sperm Binding:  Studies have identified HHV-6A/B in approximately 13.5% of semen samples from healthy sperm donors, a prevalence higher than that of most other herpesviruses in semen. Importantly, HHV-6B has been shown to specifically bind to the acrosome—the cap-like structure on the head of sperm. This means that the virus can directly interact with sperm cells and potentially travel with them into the female reproductive tract. Potential Mechanisms of Fertility Impairment:  The binding of HHV-6 to the sperm acrosome suggests the existence of a receptor for the virus on sperm, raising the possibility that this interact...
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https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
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