Possible role of human herpesvirus 6 as a trigger of autoimmune disease

-
http://www.ncbi.nlm.nih.gov/pubmed/24282390

Abstract

Human herpesvirus 6 (HHV-6) infection is common and has a worldwide distribution. Recently, HHV-6A and HHV-6B have been reclassified into two distinct species based on different biological features (genetic, antigenic, and cell tropism) and disease associations. A role for HHV-6A/B has been proposed in several autoimmune disorders (AD), including multiple sclerosis (MS), autoimmune connective tissue diseases, and Hashimoto's thyroiditis. The focus of this review is to discuss the above-mentioned AD associated with HHV-6 and the mechanisms proposed for HHV-6A/B-induced autoimmunity. HHV-6A/B could trigger autoimmunity by exposing high amounts of normally sequestered cell antigens, through lysis of infected cells. Another potential trigger is represented by molecular mimicry, with the synthesis of viral proteins that resemble cellular molecules, as a mechanism of immune escape. The virus could also induce aberrant expression of histocompatibility molecules thereby promoting the presentation of autoantigens. CD46-HHV-6A/B interaction is a new attractive mechanism proposed: HHV-6A/B (especially HHV-6A) could participate in neuroinflammation in the context of MS by promoting inflammatory processes through CD46 binding. Although HHV-6A/B has the ability to trigger all the above-mentioned mechanisms, more studies are required to fully elucidate the possible role of HHV-6A/B as a trigger of AD.

Popular Posts in the Last 7 Days

Russia: ASF is a never-ending story

-
Image
http://www.pigprogress.net/Health/Articles/2016/4/Russia-ASF-is-a-never-ending-story-2784034W/   Is this African Swine Fever Virus paper from Gallo's lab legitimate? "HBLV[HHV-6] is not ASFV." http://www.researchgate.net/publication/19958785_HBLV_is_not_ASFV  The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosi...
Read more

Is this 1988 paper on HHV-6 and African Swine Fever Virus by Dharam Ablashi legimate or should it be retracted?

-
Image
  Is this paper from Gallo's lab legitimate? HBLV[HHV-6] is not ASFV. http://www.researchgate.net/publication/19958785_HBLV_is_not_ASFV  The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of A...
Read more

The African Swine Fever Virus Rights of Man

-
Image
The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of ASFV in Heart Disease. 10. The right not to be lied to about the role of ASFV in Encephalitis. 11. The right not to be lied to about the role of ASFV in...
Read more

And updated version of the Harvard Declaration of the HHV-6 Rights of Man

-
The Harvard Declaration of the HHV-6 Rights of Man 1. The right not to be lied to by Anthony Fauci about the role of HHV-6 in AIDS. 2. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Chronic Fatigue Syndrome. 3. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Autism. 4.The right not to be lied to by Anthony Fauci about the role of HHV-6 in Multiple Sclerosis. 5. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Brain Cancer. 6. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Heart Disease. 7. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Encephalitis. 8. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Cognitive Dysfunction. 9. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Drug Hypersensitivity Syndrome. 10. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Bone Marrow Suppr...
Read more

International Cooperation Needed to Fight African Swine Fever

-
Image
http://www.thepigsite.com/swinenews/40112/international-cooperation-needed-to-fight-african-swine-fever/ The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of ASFV in Heart Disease. 10. The right not to b...
Read more

Why in the world aren't pigs being used as animal models for HHV-6?

-
http://hhv-6foundation.org/category/animal-models The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of ASFV in Heart Disease. 10. The right not to be lied to about the role of ASFV in Encephalitis. 11. T...
Read more

Chronic Fatigue Syndrome = AIDS

-
Fcg receptors (FcγRs) in ME/CFS by Dr. Isabel Barao   https://batemanhornecenter.org/uncovering-biomarkers-fcg-receptors/   "HIV -infected MDM caused the defective Fc R-mediated signaling"   www.jimmunol.org/content/168/6/2895.full.pdf
Read more

Did Gallo bully Dharam Ablashi into covering up the truth about HHV-6?

-
Image
HBLV[HHV-6] is not ASFV. http://www.researchgate.net/publication/19958785_HBLV_is_not_ASFV  The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of ASFV in Heart Disease. 10. The right not to be lied...
Read more

Police detain journalists over investigation of African swine fever

-
Image
https://belsat.eu/en/articles/police-detain-journalists-over-investigation-african-swine-fever/ The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of ASFV in Heart Disease. 10. The right not to be lied t...
Read more

Popular Post in the Last 30 Days

Is this the real AIDS epidemic, and is it just getting started?

-
  AIDS Related Kaposi's Sarcoma Market to Experience Notable Some of the key facts of the AIDS Related Kaposi's Sarcoma Market Report: • The AIDS Related Kaposi's Sarcoma market size is anticipated to grow with a significant CAGR during the study period (2019-2032) • Key AIDS Related Kaposi's Sarcoma Companies: Parirenyatwa Hospital, Ligand Pharmaceuticals, Otsuka America Pharmaceutical, Lederle Laboratories, Sequus Pharmaceuticals, SUGEN, Cytran, Abbott, and others • Key AIDS Related Kaposi's Sarcoma Therapies: abacavir/3TC/zidovudine, Bexarotene, Vesnarinone, Mitoxantrone hydrochloride, Doxorubicin hydrochloride (liposomal), SU5416, IM862, Ritonavir, and others • The AIDS Related Kaposi's Sarcoma market is expected to surge due to the disease's increasing prevalence and awareness during the forecast period. Furthermore, launching various multiple-stage AIDS Related Kaposi's Sarcoma pipeline products will significantly revolutionize the AIDS Related Kap...
Read more

One of the most important papers ever published on HHV-6

-
http://www.journalofclinicalvirology.com/article/S1386-6532%2809%2900194-2/abstract Conclusion These results imply that HHV-6A, either in latent form or during acute infection, directly transactivates HERV-K18. This HERV-K18 induction may be mediated through IFN-α that is produced by the HHV-6A-infected cells. The functional implications of superantigen expression are discussed. Wikipedia on Superantigen: Superantigens (SAgs) are a class of antigens which cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. SAgs can be produced by pathogenic microbes (including viruses , mycoplasma , and bacteria ) [1] as a defense mechanism against the immune system. [2] Compared to a normal antigen -induced T-cell response where .0001-.001% of the body’s T-cells are activated, these SAgs are capable of activating up to 25% of the body’s T-cells. [ citation needed ] Furthermore, Anti- CD3 and Anti- CD28 Antibodi...
Read more

Perplexity on K.S. and AIDS and inflammation

-
  Discuss the issue of K.S. happening despite ART use Kaposi sarcoma (KS) can and does occur in people living with HIV, even when they are on effective antiretroviral therapy (ART). While ART has dramatically reduced the incidence and severity of KS, several important points explain why KS still happens despite ART use: Immune Reconstitution Inflammatory Syndrome (IRIS): Some individuals develop KS or see it worsen shortly after starting ART, in what is known as KS-IRIS. This is thought to be due to immune system recovery leading to a paradoxical inflammatory response, which can unmask or exacerbate KS—even when HIV viral load drops and CD4 counts begin to rise. Rapidly disseminated or aggressive KS has been reported in these cases, sometimes within months of starting ART. Persistent Risk Despite Good Immune Recovery: Studies have documented cases of KS in patients who maintain undetectable HIV viral loads and normal CD4 counts for years. This includes long-term HIV survivors and o...
Read more

"Kaposi Sarcoma and HIV have a weak relationship"

-
  The Relationship Between HIV and Kaposi Sarcoma Topic:  Health & Medicine   Words: 1112   Pages: 4   Apr 22nd, 2022 Explanation of Main Results This paper investigated the nature of the relationship between HIV and Kaposi Sarcoma. The findings of this paper showed that rare skin cancer was the HIV-defining condition in only 48.7% of the cases sampled. Comparatively, 51.3% of the cases sampled did not show a direct correlation between HIV and Kaposi Sarcoma. These details emerged in the case study summary, which showed that the percentage of female participants suffering from HIV disease, but did not have Kaposi Sarcoma was 60.5%. This is a relatively larger percentage of people compared to 39.5% of people who suffered from HIV and Kaposi Sarcoma. Comparatively, an analysis of male respondents showed a different pattern because there were higher percentages of people (57.5%) who suffered from HIV and Kaposi Sarcoma, as opposed to the number of people who su...
Read more

HHV-6 and Male infertility (from Perplexity)

-
  Make the case that HHV-6 may be responsible for the fertility problems in men Make the case that HHV-6 may be responsible for the fertility problems in men There is a growing body of evidence suggesting that Human Herpesvirus 6 (HHV-6) may play a role in male fertility problems. Here is the case based on recent research findings: Prevalence in Semen and Sperm Binding:  Studies have identified HHV-6A/B in approximately 13.5% of semen samples from healthy sperm donors, a prevalence higher than that of most other herpesviruses in semen. Importantly, HHV-6B has been shown to specifically bind to the acrosome—the cap-like structure on the head of sperm. This means that the virus can directly interact with sperm cells and potentially travel with them into the female reproductive tract. Potential Mechanisms of Fertility Impairment:  The binding of HHV-6 to the sperm acrosome suggests the existence of a receptor for the virus on sperm, raising the possibility that this interact...
Read more

Moronic AIDS Researchers Still Not Focused on HHV-6

-
Image
http://aidsinfo.nih.gov/news/1508/nih-led-study-explores-prevention-of-heart-disease-in-hiv-infected-people "Is there a danger, in molecular biology, that the accumulation of data will get so far ahead of its assimilation into a conceptual framework that the data will eventually prove an encumbrance? Part of the trouble is that excitement of the chase leaves little time for reflection. And there are grants for producing data, but hardly any for standing back in contemplation" . -- John Maddox Finding wood among the trees. Nature 1988; 335:11.  http://www.virusmyth.com/aids/hiv/ffsearch.htm
Read more

Popular Posts from the Last Year

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

-
  Rebecca Culshaw’s Substack articles establish a foundation for arguing that the mass promotion and use of PrEP (pre-exposure prophylaxis) in HIV prevention could be considered a form of “genocide,” rooted in several lines of critique that challenge both the scientific and ethical underpinnings of the intervention. ​ Critique of Efficacy Claims Culshaw repeatedly questions the reliability of the efficacy data cited for PrEP, especially the widely publicized claim of “99% effectiveness.” She critiques the primary studies behind this figure, particularly the UK “Impact Trial,” highlighting that its actual observed efficacy was only 86%, and that even this figure is derived from retrospective, less scientifically rigorous analysis. She emphasizes that PrEP, to justify the aggressive and potentially coercive marketing campaigns behind it, should meet a much higher bar of evidence given its target population often consists of healthy individuals. By questioning what she perceives as st...
Read more

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
Read more

Why Brigitte Huber may be the most important AIDS and Chronic Fatigue Syndrome researcher

-
Image
  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
Read more

From Perplexity A.I.: A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences.

-
  A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences. Scale and Impact of AIDS The way AIDS was defined and classified determined how millions of people were diagnosed, treated, and socially perceived. Nosological mistakes have led to unnecessary suffering, stigmatization, discrimination, and sometimes fatal outcomes for entire populations. During the early epidemic, AIDS definitions dictated global policies, resource allocation, and public health strategies, impacting the lives of marginalized groups and shaping health systems globally. Misdirected Interventions and Suffering If the nosology—such as equating all immune compromise with AIDS or failing to recognize other causes—was incorrect, countless lives may have been lost or damaged due to misdiagnosis, inappropriate tre...
Read more

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

-
Image
https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
Read more