Defreitas, CFS and HHV-6-induced HERV-K18: Putting it all together

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Connecting all of these may ultimately explain the retroviral involvement in CFS (as well as HIV-positive and HIV-negative AIDS).


Konnie Knox was looking into the HTLV connection to HHV-6:
The goals of the proposed studies are:
  • to use contemporary molecular diagnostic techniques in an attempt to confirm the findings of Dr. DeFreitas with respect to the presence of HTLV-2 DNA sequences in the white blood cells of patients with CFS
  • To correlate the presence of HTLV-2 DNA sequences with the presence of active infections with human herpesvirus six (HHV-6) or Epstein-Barr virus (EBV), two viruses that have been implicated in CFS

Role of the Human Endogenous Retrovirus HERV-K18 in Autoimmune Disease Susceptibility: Study in the Spanish Population and Meta-Analysis 

Conclusion

Association of the HERV-K18.3 haplotype in chromosome 1 with autoimmune-disease susceptibility was confirmed through meta-analysis.
 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062090


HHV-6A infection induces expression of HERV-K18-encoded superantigen.

CONCLUSION:

These results imply that HHV-6A, either in latent form or during acute infection, directly transactivates HERV-K18. This HERV-K18 induction may be mediated through IFN-alpha that is produced by the HHV-6A-infected cells. The functional implications of superantigen expression are discussed.
 http://www.ncbi.nlm.nih.gov/pubmed/19505843

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"A flash of potential good news from the front lines of the coronavirus pandemic: A treatment is showing promise. Doctors in France, South Korea and the U.S. are using an antimalarial drug known as hydroxychloroquine with success. We are physicians treating patients with Covid-19, and the therapy appears to be making a difference. It isn’t a silver bullet, but if deployed quickly and strategically the drug could potentially help bend the pandemic’s “hockey stick” curve." https://www.wsj.com/articles/these-drugs-are-helping-our-coronavirus-patients-11584899438
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Is this 1988 paper on HHV-6 and African Swine Fever Virus by Dharam Ablashi legimate or should it be retracted?

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  Is this paper from Gallo's lab legitimate? HBLV[HHV-6] is not ASFV. http://www.researchgate.net/publication/19958785_HBLV_is_not_ASFV  The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of A...
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Did Gallo bully Dharam Ablashi into covering up the truth about HHV-6?

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HBLV[HHV-6] is not ASFV. http://www.researchgate.net/publication/19958785_HBLV_is_not_ASFV  The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of ASFV in Heart Disease. 10. The right not to be lied...
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http://www.journalofclinicalvirology.com/article/S1386-6532%2809%2900194-2/abstract Conclusion These results imply that HHV-6A, either in latent form or during acute infection, directly transactivates HERV-K18. This HERV-K18 induction may be mediated through IFN-α that is produced by the HHV-6A-infected cells. The functional implications of superantigen expression are discussed. Wikipedia on Superantigen: Superantigens (SAgs) are a class of antigens which cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. SAgs can be produced by pathogenic microbes (including viruses , mycoplasma , and bacteria ) [1] as a defense mechanism against the immune system. [2] Compared to a normal antigen -induced T-cell response where .0001-.001% of the body’s T-cells are activated, these SAgs are capable of activating up to 25% of the body’s T-cells. [ citation needed ] Furthermore, Anti- CD3 and Anti- CD28 Antibodi...
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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
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  A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences. Scale and Impact of AIDS The way AIDS was defined and classified determined how millions of people were diagnosed, treated, and socially perceived. Nosological mistakes have led to unnecessary suffering, stigmatization, discrimination, and sometimes fatal outcomes for entire populations. During the early epidemic, AIDS definitions dictated global policies, resource allocation, and public health strategies, impacting the lives of marginalized groups and shaping health systems globally. Misdirected Interventions and Suffering If the nosology—such as equating all immune compromise with AIDS or failing to recognize other causes—was incorrect, countless lives may have been lost or damaged due to misdiagnosis, inappropriate tre...
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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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