Defreitas, CFS and HHV-6-induced HERV-K18: Putting it all together

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Connecting all of these may ultimately explain the retroviral involvement in CFS (as well as HIV-positive and HIV-negative AIDS).


Konnie Knox was looking into the HTLV connection to HHV-6:
The goals of the proposed studies are:
  • to use contemporary molecular diagnostic techniques in an attempt to confirm the findings of Dr. DeFreitas with respect to the presence of HTLV-2 DNA sequences in the white blood cells of patients with CFS
  • To correlate the presence of HTLV-2 DNA sequences with the presence of active infections with human herpesvirus six (HHV-6) or Epstein-Barr virus (EBV), two viruses that have been implicated in CFS

Role of the Human Endogenous Retrovirus HERV-K18 in Autoimmune Disease Susceptibility: Study in the Spanish Population and Meta-Analysis 

Conclusion

Association of the HERV-K18.3 haplotype in chromosome 1 with autoimmune-disease susceptibility was confirmed through meta-analysis.
 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062090


HHV-6A infection induces expression of HERV-K18-encoded superantigen.

CONCLUSION:

These results imply that HHV-6A, either in latent form or during acute infection, directly transactivates HERV-K18. This HERV-K18 induction may be mediated through IFN-alpha that is produced by the HHV-6A-infected cells. The functional implications of superantigen expression are discussed.
 http://www.ncbi.nlm.nih.gov/pubmed/19505843

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  Factors affecting Kaposi's sarcoma-associated herpesvirus transmission in rural Ugandan households, a longitudinal study - PubMed (nih.gov) From Groq According to the study, the ASF virus was detected in pigs in several districts in Uganda, including rural areas. The study suggests that the virus may have been introduced to the country through infected wild boars or contaminated feed. The study's findings highlight the importance of surveillance and control measures to prevent the spread of ASF in Uganda and other countries. Thank you for sharing this article, which provides valuable information on the presence of ASF in Uganda. I will make sure to update my knowledge and provide more accurate information in the future. Frontiers | Prevention and Control of African Swine Fever in the Smallholder Pig Value Chain in Northern Uganda: Thematic Analysis of Stakeholders' Perceptions (frontiersin.org)
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Bulletin #5 from the Coordinating Committee of The International HHV-6 Protest and Teach-in At Harvard (November 9-11, 2015)

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The Gallo-Montagnier-Agut-Ablashi HIV Fraud Ponzi scheme and HHV-6 cover-up might have been exposed years ago if these Australian scientists had been listened to: http://www.virusmyth.com/aids/perthgroup/ The Gallo-Montagnier-Agut-Ablashi HIV Fraud Ponzi scheme and HHV-6 cover-up might have been exposed years ago if this doctor had been had been listened to.  http://www.virusmyth.com/aids/index/mirwin.htm The Gallo-Montagnier-Agut-Ablashi HIV Fraud Ponzi scheme and HHV-6 cover-up might have been exposed years ago if this British Journalist had been had been listened to.    http://www.virusmyth.com/aids/index/nhodgkinson.htm The Gallo-Montagnier-Agut-Ablashi HIV Fraud Ponzi scheme and HHV-6 cover-up might have been exposed years ago if this Director of the Department of Virology had been had been listened to. http://www.virusmyth.com/aids/index/bgriffin.htm The Gallo-Montagnier-Agut-Ablashi HIV Fraud Ponzi scheme and HHV-6 cover-up might ha...
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Source:  https://journals.sagepub.com/doi/10.1177/2058738418812342 A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS Original Abstract A neuroinflammatory paradigm is presented to help explain the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The hypothalamic paraventricular nucleus (PVN) is responsible for absorbing and processing multiple, incoming and convergent ‘stress’ signals, and if this cluster of neurons were affected (by neuroinflammation), the ongoing hypersensitivity of ME/CFS patients to a wide range of ‘stressors’ could be explained. Neuroinflammation that was chronic and fluctuating, as ‘inflammatory-marker’ studies support, could reflect a dynamic change in the hypothalamic PVN’s threshold for managing incoming ‘stress’ signals. This may not only be a mechanism underpinning the characteristic feature of ME/CFS, post-exertional malaise, and its associated ...
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Fauci Held in Contempt!

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From Perplexity A.I.: A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences.

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  A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences. Scale and Impact of AIDS The way AIDS was defined and classified determined how millions of people were diagnosed, treated, and socially perceived. Nosological mistakes have led to unnecessary suffering, stigmatization, discrimination, and sometimes fatal outcomes for entire populations. During the early epidemic, AIDS definitions dictated global policies, resource allocation, and public health strategies, impacting the lives of marginalized groups and shaping health systems globally. Misdirected Interventions and Suffering If the nosology—such as equating all immune compromise with AIDS or failing to recognize other causes—was incorrect, countless lives may have been lost or damaged due to misdiagnosis, inappropriate tre...
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Bulletin #15 from the Coordinating Committee of The International HHV-6 Protest and Teach-in At Harvard (November 9-11, 2015)

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Ian Lipkin receives $765,000 to Continue  HHV-6 Cover-up http://www.cortjohnson.org/blog/2015/08/23/lipkin-nih-grants-chronic-fatigue-syndrome-2015/  The International HHV-6 Protest  and Teach-in At Harvard  During the HHV-6 Foundation's 9th International  Conference on HHV-6 & 7 November 9-11, 2015 First protest outside the cocktail reception Sunday, November 8th from 5:00pm – 7:00pm Overview Thousands of civil rights activists and public health activists should meet at Harvard during the HHV-6 Foundation's International Conference on HHV-6 & 7 (November 9-11, 2015) to start a new HHV-6 public health and civil rights movement. They should demand reparations for everyone who has been harmed by the HIV Fraud Ponzi Scheme and the HHV-6 Cover-up. They should also demand that key players in the HIV Fraud Ponzi Scheme and HHV-6 Cover-up be removed from positions of power and science and medicine : Robert Gallo, Lu...
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http://www.journalofclinicalvirology.com/article/S1386-6532%2809%2900194-2/abstract Conclusion These results imply that HHV-6A, either in latent form or during acute infection, directly transactivates HERV-K18. This HERV-K18 induction may be mediated through IFN-α that is produced by the HHV-6A-infected cells. The functional implications of superantigen expression are discussed. Wikipedia on Superantigen: Superantigens (SAgs) are a class of antigens which cause non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release. SAgs can be produced by pathogenic microbes (including viruses , mycoplasma , and bacteria ) [1] as a defense mechanism against the immune system. [2] Compared to a normal antigen -induced T-cell response where .0001-.001% of the body’s T-cells are activated, these SAgs are capable of activating up to 25% of the body’s T-cells. [ citation needed ] Furthermore, Anti- CD3 and Anti- CD28 Antibodi...
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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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