Defreitas, CFS and HHV-6-induced HERV-K18: Putting it all together

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Connecting all of these may ultimately explain the retroviral involvement in CFS (as well as HIV-positive and HIV-negative AIDS).


Konnie Knox was looking into the HTLV connection to HHV-6:
The goals of the proposed studies are:
  • to use contemporary molecular diagnostic techniques in an attempt to confirm the findings of Dr. DeFreitas with respect to the presence of HTLV-2 DNA sequences in the white blood cells of patients with CFS
  • To correlate the presence of HTLV-2 DNA sequences with the presence of active infections with human herpesvirus six (HHV-6) or Epstein-Barr virus (EBV), two viruses that have been implicated in CFS

Role of the Human Endogenous Retrovirus HERV-K18 in Autoimmune Disease Susceptibility: Study in the Spanish Population and Meta-Analysis 

Conclusion

Association of the HERV-K18.3 haplotype in chromosome 1 with autoimmune-disease susceptibility was confirmed through meta-analysis.
 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062090


HHV-6A infection induces expression of HERV-K18-encoded superantigen.

CONCLUSION:

These results imply that HHV-6A, either in latent form or during acute infection, directly transactivates HERV-K18. This HERV-K18 induction may be mediated through IFN-alpha that is produced by the HHV-6A-infected cells. The functional implications of superantigen expression are discussed.
 http://www.ncbi.nlm.nih.gov/pubmed/19505843

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WTF?

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Science and Society at the Crossroads: Skepticism vs. Denial and Elitism vs. Public Engagement Report on an international meeting at Chicheley Hall, 15-16 June 2015 Principal organizer and curator: Prof Stephan Lewandowsky (University of Bristol) https://figshare.com/articles/RS_scienceandsociety_September_2015_pdf/2061696
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This is shocking—or is it? A man died of AIDS despite his “HIV” being under control https://substack.com/@rebeccaculshawsmith/p-200158509 Excerpt: I am really sorry that this man was so failed by the medical system, and I am sorry for what his surviving family members are going through. They must be internally screaming with frustration. I do wish more information had been given as to what medications he was on and his surrogate markers of T cells and viral load; the context of the article certainly indicates that his markers were normal. However, this case study ought to serve as a cautionary tale. An “HIV” diagnosis is dangerous not because it might lead to AIDS, but because it retains people in care using treatments that cause not only kidney failure, bone density loss, liver damage (in the early days of the protease inhibitors), metabolic issues such as lipodystrophy and elevated cholesterol, but also massively accelerated aging, despite the total suppression of “HIV.” An urgent re...
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Perplexity names the AIDS Paradigm 20

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Source:  https://journals.sagepub.com/doi/10.1177/2058738418812342 A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS Original Abstract A neuroinflammatory paradigm is presented to help explain the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The hypothalamic paraventricular nucleus (PVN) is responsible for absorbing and processing multiple, incoming and convergent ‘stress’ signals, and if this cluster of neurons were affected (by neuroinflammation), the ongoing hypersensitivity of ME/CFS patients to a wide range of ‘stressors’ could be explained. Neuroinflammation that was chronic and fluctuating, as ‘inflammatory-marker’ studies support, could reflect a dynamic change in the hypothalamic PVN’s threshold for managing incoming ‘stress’ signals. This may not only be a mechanism underpinning the characteristic feature of ME/CFS, post-exertional malaise, and its associated ...
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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
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Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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Shaking the Very Foundations of AIDS Orthodoxy : Kaposi's Sarcoma: Two studies of this condition pose a question once considered a heresy: What if HIV is not the cause of the epidemic? January 28, 1990 | KATIE LEISHMAN | Katie Leishman, a national correspondent for the Atlantic, is the author of "Epidemic," to be published by Doubleday. http://articles.latimes.com/1990-01-28/opinion/op-1358_1_aids-patients This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/...
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