HHV-6 and Natural Killer Cells

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P.P. Banerjee on IFN-gamma-Dependent Demyelinating Activity by Natural Killer Cells is Regulated by HLA-G Upregulation on Oligodendrocytes During HHV-6 Infection.
http://www.scivee.tv/node/28444

HHV-6 Modulates Natural Killer Cells Via IL-15 Production
http://www.jci.org/articles/view/118557/version/1/pdf/render

HHV-7 and Natural Killer Cells
The Human Herpesvirus-7 (HHV-7) U21 Immunoevasin Subverts NK-Mediated Cytoxicity through Modulation of MICA and MICB
Christine L. Schneider and Amy W. Hudson
Abstract
Herpesviruses have evolved numerous immune evasion strategies to facilitate establishment of lifelong persistent infections. Many herpesviruses encode gene products devoted to preventing viral antigen presentation as a means of escaping detection by cytotoxic T lymphocytes. The human herpesvirus-7 (HHV-7) U21 gene product, for example, is an immunoevasin that binds to class I major histocompatibility complex molecules and redirects them to the lysosomal compartment. Virus infection can also induce the upregulation of surface ligands that activate NK cells. Accordingly, the herpesviruses have evolved a diverse array of mechanisms to prevent NK cell engagement of NK-activating ligands on virus-infected cells. Here we demonstrate that the HHV-7 U21 gene product interferes with NK recognition. U21 can bind to the NK activating ligand ULBP1 and reroute it to the lysosomal compartment. In addition, U21 downregulates the surface expression of the NK activating ligands MICA and MICB, resulting in a reduction in NK-mediated cytotoxicity. These results suggest that this single viral protein may interfere both with CTL-mediated recognition through the downregulation of class I MHC molecules as well as NK-mediated recognition through downregulation of NK activating ligands.
PLoS Pathog. 2011 November; 7(11): e1002362.

The Human Herpesvirus-7 (HHV-7) U21 Immunoevasin Subverts NK-Mediated Cytoxicity through Modulation of MICA and MICB
Christine L. Schneider, Amy W. Hudson
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
Abstract
Herpesviruses have evolved numerous immune evasion strategies to facilitate establishment of lifelong persistent infections. Many herpesviruses encode gene products devoted to preventing viral antigen presentation as a means of escaping detection by cytotoxic T lymphocytes. The human herpesvirus-7 (HHV-7) U21 gene product, for example, is an immunoevasin that binds to class I major histocompatibility complex molecules and redirects them to the lysosomal compartment. Virus infection can also induce the upregulation of surface ligands that activate NK cells. Accordingly, the herpesviruses have evolved a diverse array of mechanisms to prevent NK cell engagement of NK-activating ligands on virus-infected cells. Here we demonstrate that the HHV-7 U21 gene product interferes with NK recognition. U21 can bind to the NK activating ligand ULBP1 and reroute it to the lysosomal compartment. In addition, U21 downregulates the surface expression of the NK activating ligands MICA and MICB, resulting in a reduction in NK-mediated cytotoxicity. These results suggest that this single viral protein may interfere both with CTL-mediated recognition through the downregulation of class I MHC molecules as well as NK-mediated recognition through downregulation of NK activating ligands.
http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002362

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New cartoon

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"HHV-6 is actually likely to reduce HIV patient survival by accelerating the depletion of CD4 and CD8 T cells. HHV-6A was shown to accelerate AIDS progression in macaques.  Macaques co-infected with simian HIV and HHV-6A died quickly and showed a dramatic depletion in both CD4+ and CD8+ T cells, whereas those infected with only simian HIV never progressed to full blown AIDS."  "We believe that infections are the most logical explanation for the inflammation neurodegeneration associated with Alzheimer’s , but don’t believe that there is a single pathogen responsible. HHV-6A and HHV-7 were identified as likely culprits in 2018 paper , using RNAseq analysis by Readhead and team. Two subsequent studies did not find an increase in HHV-6/7 using the same data, but at the same time did not find a significant presence of ANY herpesviruses in the brain, which we know is not the case. Dozens of careful studies have identified a high prevalence of low-level HHV-6 and HSV1 DN...
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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

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Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
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How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
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Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

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https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
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