Human herpesvirus-6A/B binds to spermatozoa acrosome and is the most prevalent herpesvirus in semen from sperm donors.

-
 http://www.ncbi.nlm.nih.gov/pubmed/23144982

PLoS One. 2012;7(11):e48810. doi: 10.1371/journal.pone.0048810. Epub 2012 Nov 7.

Abstract

An analysis of all known human herpesviruses has not previously been reported on sperm from normal donors. Using an array-based detection method, we determined the cross-sectional frequency of human herpesviruses in semen from 198 Danish sperm donors. Fifty-five of the donors had at least one ejaculate that was positive for one or more human herpesvirus. Of these 27.3% (n = 15) had a double herpesvirus infection. If corrected for the presence of multiple ejaculates from some donors, the adjusted frequency of herpesviruses in semen was 27.2% with HSV-1 in 0.4%; HSV-2 in 0.1%; EBV in 6.3%; HCMV in 2.7%; HHV-6A/B in 13.5%; HHV-7 in 4.2%, whereas none of the samples had detectable VZV or HHV-8. Subsequently, we examined longitudinally data on ejaculates from 11 herpesvirus-positive donors. Serial analyses revealed that a donor who tested positive for herpesvirus at one time point did not necessarily remain positive over time. For the most frequently found herpesvirus, HHV-6A/B, we examined its association with sperm. For HHV-6A/B PCR-positive semen samples, HHV-6A/B could be detected on the sperm by flow cytometry. Conversely, PCR-negative semen samples were negative by flow cytometry. HHV-6B was shown to associate with sperm within minutes in a concentration dependent manner. Confocal microscopy demonstrated that HHV-6B associated with the sperm head, but only to sperm with an intact acrosome. Taken together, our data suggest that HHV-6A/B could be transported to the uterus via binding to the sperm acrosome. Moreover, we find a 10 times higher frequency of HHV-7 in semen from healthy individuals than previously detected. Further research is required to determine the potential risk of using herpesvirus-positive donor semen. Longitudinally analyses of ejaculate series indicate that implementation of quarantine for a donor shown to shed a herpesvirus is not a tenable solution.

Popular Posts in the Last 7 Days

Consciousness of Guilt in Science and Medicine (From Perplexity A.I.)

-
  Develop the idea that there is something in science and medicine called "consciousness of fraud" (like consciousness of guilt) and list the telltale signs that a scientist is inadvertently showing it. The concept of "consciousness of fraud" in science and medicine parallels legal "consciousness of guilt," reflecting subtle behavioral and linguistic cues that betray a researcher's awareness of misconduct. These involuntary signs manifest through writing patterns, methodological choices, and professional behavior, often revealing attempts to conceal fabricated or manipulated data. Below are key telltale signs, synthesized from empirical studies and expert analyses of scientific fraud: 🔍 Linguistic and Writing Patterns Obfuscation in Language: Fraudulent papers use significantly more jargon, abstract terms, and complex phrasing to obscure methods or results. This "linguistic masking" aims to deter scrutiny, with fraudulent texts containing ~1...
Read more
-
Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
Read more

We asked Perplexity A.I. to make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS.

-
 From Perplexity A.I. Make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS. Castleman disease, particularly its HIV-associated multicentric form (HIV-MCD), challenges core paradigms in AIDS medicine across nosology, epidemiology, and virology. Below is a detailed analysis of how this rare lymphoproliferative disorder complicates established frameworks. 🧬 Nosological Challenges HIV-MCD disrupts traditional AIDS classification by: Blurring diagnostic boundaries: It exhibits inflammatory symptoms (e.g., fever, cytopenia) and histopathology (plasmablastic proliferation) that overlap with—but are distinct from—classic AIDS-defining conditions like lymphoma or opportunistic infections. Dual-pathogen dynamics: Diagnosis requires confirming HHV-8 co-infection, positioning it as a viral co-pathogenesis rather than a direct HIV complication. This contrasts with AIDS nosology, which typically centers on HIV as the primary etiological agent. U...
Read more

Can one make the case that the nosology of AIDS involves circular reasoning about HIV positivity?

-
  From Perplexity A.I.  Can one make the case that the nosology of AIDS involves circular reasoning about HIV positivity? Yes, one can make the case that the nosology of AIDS involves a degree of circular reasoning regarding HIV positivity, based on how diagnostic criteria are structured. How the Circularity Arises Definition Tied to HIV Status: According to CDC and WHO criteria, a person can only be diagnosed with AIDS if they are HIV-positive and meet certain clinical or immunological thresholds (such as a CD4 count below 200 cells/mm³ or an AIDS-defining condition). Clinical Events Require HIV Confirmation: Many of the clinical syndromes and opportunistic infections that define AIDS (e.g., Pneumocystis pneumonia, certain cancers) can occur in other immunocompromised states, but are only labeled as "AIDS" if HIV infection is confirmed. Research and Subtype Definitions: Even in research on HIV-associated neurocognitive disorders (HAND), the impairment is only classified as H...
Read more

Popular Post in the Last 30 Days

Consciousness of Guilt in Science and Medicine (From Perplexity A.I.)

-
  Develop the idea that there is something in science and medicine called "consciousness of fraud" (like consciousness of guilt) and list the telltale signs that a scientist is inadvertently showing it. The concept of "consciousness of fraud" in science and medicine parallels legal "consciousness of guilt," reflecting subtle behavioral and linguistic cues that betray a researcher's awareness of misconduct. These involuntary signs manifest through writing patterns, methodological choices, and professional behavior, often revealing attempts to conceal fabricated or manipulated data. Below are key telltale signs, synthesized from empirical studies and expert analyses of scientific fraud: 🔍 Linguistic and Writing Patterns Obfuscation in Language: Fraudulent papers use significantly more jargon, abstract terms, and complex phrasing to obscure methods or results. This "linguistic masking" aims to deter scrutiny, with fraudulent texts containing ~1...
Read more
-
Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
Read more

We asked Perplexity A.I. to make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS.

-
 From Perplexity A.I. Make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS. Castleman disease, particularly its HIV-associated multicentric form (HIV-MCD), challenges core paradigms in AIDS medicine across nosology, epidemiology, and virology. Below is a detailed analysis of how this rare lymphoproliferative disorder complicates established frameworks. 🧬 Nosological Challenges HIV-MCD disrupts traditional AIDS classification by: Blurring diagnostic boundaries: It exhibits inflammatory symptoms (e.g., fever, cytopenia) and histopathology (plasmablastic proliferation) that overlap with—but are distinct from—classic AIDS-defining conditions like lymphoma or opportunistic infections. Dual-pathogen dynamics: Diagnosis requires confirming HHV-8 co-infection, positioning it as a viral co-pathogenesis rather than a direct HIV complication. This contrasts with AIDS nosology, which typically centers on HIV as the primary etiological agent. U...
Read more

If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event?

-
 From Perplexity A.I.  If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event? If the scientific establishment were to fundamentally revise the current understanding of AIDS and declare that HIV is not the cause, this would indeed constitute a Black Swan event—an extremely rare, unpredictable, and highly consequential occurrence that dramatically alters conventional wisdom and scientific consensus. A Black Swan event is defined by its rarity, profound impact, and the tendency for people to rationalize it retrospectively as if it could have been expected. The current scientific consensus, established in the late 1980s and reinforced by overwhelming evidence, is that HIV is the causative agent of AIDS. This consensus is based on decades of research, clinical experience, and the effectiveness of HIV-targeting treatments. If the establishment were to reverse this consensus, it would be unpreceden...
Read more

Are any endogenous retroviruses reactivated in AIDS and do any of them act like superantigens?

-
From Perplexity A.I. Are any endogenous retroviruses reactivated in AIDS and do any of them act like superantigens? Yes, several human endogenous retroviruses (HERVs) are reactivated in AIDS, particularly during HIV infection, and some evidence suggests that certain HERV proteins may have superantigen-like activity. Reactivation of HERVs in AIDS/HIV Infection HERV-K (HML-2) is the most studied family and is consistently shown to be upregulated in HIV-infected cells and patients. HIV infection increases HERV-K RNA and protein expression in various cell lines (e.g., U-87 MG, H9 T cells, MT2, Jurkat) and primary CD4+ T cells, often in a dose- and time-dependent manner. Other HERV families such as HERV-E, HERV-W, ERV-9, and subgroups of HERV-K (HML-3, HML-4, HML-10) are also upregulated in HIV infection. The HIV-1 Tat protein plays a key role in activating HERV expression by transactivating HERV-K long terminal repeats (LTRs), opening chromatin structure, and inducing transcription factors...
Read more

The malware created by Peter Duesberg nosology (if it was wrong)

-
  From Perplexity A.I. Did Peter Duesberg get the nosology of AIDS wrong? Peter Duesberg did get the nosology of AIDS wrong, according to the overwhelming scientific consensus. Duesberg’s central claim—known as the "Duesberg hypothesis"—was that AIDS is not caused by HIV, but rather by noninfectious factors such as recreational drug use or antiretroviral drugs, and that HIV is a harmless passenger virus. He also argued that AIDS in Africa was misdiagnosed and not due to HIV, attributing cases instead to malnutrition and other local factors. The scientific community has thoroughly examined and rejected Duesberg’s views. His arguments have been criticized for selectively ignoring or dismissing the extensive evidence showing that HIV infection predicts who will develop AIDS, and that controlling HIV with antiretroviral therapy prevents AIDS-defining illnesses and deaths. Reviews in leading journals such as Nature and Science concluded that Duesberg’s reading of the literature wa...
Read more

Popular Posts from the Last Year

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
Read more

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Dr. Rebecca Culshaw Smith's book is discussed on Twitter

-
  #AIDS #HIV #Truvada #TruvadaVictims #ClassAction An eye-opening, heart-breaking investigation. Dr. Rebecca Culshaw Smith's groundbreaking book exposes the tragic reality of 26,000 plaintiffs suing Gilead over the toxic side effects of HIV drug Truvada. https://t.co/PHVoKrafcU pic.twitter.com/hbh3mN4tdI — MyBookLists (@mybooklists) September 12, 2024
Read more

Is African Swine Fever a threat to human health in Congo?

-
Image
https://pmc.ncbi.nlm.nih.gov/articles/PMC7045278/ Our prior reporting on African Swine Fever ASF contaminated meat not entirely safe Besides, ASF-contaminated food could not be entirely safe for humans. “According to the latest research, though the virus is not dangerous to humans, there are documented reactions [of human bodies to ASF] in the form of production of antibodies against it. This indicates an ASF attempt to infect the body and the possibility of a serious weakening of the immune system,” Pavlov said. From 2018 ASF Russia: consumers want liability for sellers of contaminated meat (pigprogress.net) African Swine Fever is a big story already because, when and if it spreads to all of Western Europe and China, it will cause the collapse of a major portion of the agricultural export economies of the affected countries. We're talking about many billions of dollars of losses. And the problem is not temporary because those countries will be suspected of harboring the disease ...
Read more

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
Read more

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

-
Image
https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more