HHV-6 Transmission

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cartoon, hhv-6 , transmission, congress, fauci, public health,hiv, cfs, chronic fatigue syndrome
"Both intrauterine and sexual transmission of human herpesvirus (HHV)-6 and HHV-7 have been suggested."
http://www.ncbi.nlm.nih.gov/pubmed/17922393

"Transmission of this virus is believed to occur as a result of exposure to saliva."

http://www.emergingworlds.com/ch_viruses_detail.cfm?vPageid=41 

"Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA."

 http://www.ncbi.nlm.nih.gov/pubmed/15170644

"HHV-6 has a very high prevalence (close to 100% of the world’s population has been exposed). It is transmitted mainly by saliva. Transmission occurs usually within the first two years of life; primary infection is often associated with a febrile condition and sometimes with the onset of roseola (exanthem subitum). Two variants of the virus are known, HHV-6A and HHV-6B. HHV-6 is mainly lymphotropic, infecting a broad range of immune cells including T cells, monocytes, NK cells; however the virus can also infect many other tissues such as brain or liver."

http://www.redlabs.be/red-labs/our-science/viral-infections.php

"Virus replicated in the salivary glands and secreted in saliva is the epidemiologically proven source of transmission. Other routes of transmission have been suggested but remain to be proven."

http://wwwnc.cdc.gov/eid/article/5/3/99-0306_article 

"Infection with human herpes virus 6 (HHV-6) occurs in infancy or early childhood. Primary HHV-6 infection accounts for 10-20% of all febrile illnesses in infants and children less than 3 years of age seen in pediatric emergency departments. Serious complications have been described such as meningitis, encephalitis, hepatitis (including neonatal hepatitis), disseminated infection and hemophagocytic syndrome. At least one case of verified transmission from mother to foetus has been described. HHV-6 is closely related to CMV, which is transmitted from mother to infant in 0.5-2.0 of all pregnancies, most often as a result of reactivation of the virus."

http://www.nature.com/pr/journal/v41/n4s/full/pr19971488a.html

 "Respiratory transmission among persons with close contact with one another is the major route of primary infection."
 http://www.nature.com/jidsp/journal/v6/n3/full/5640056a.html


Unique route for human herpesvirus transmission: HHV-6 and chromosomal integration

 http://www.futuremedicine.com/doi/abs/10.2217/fvl.09.3


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Source:  https://journals.sagepub.com/doi/10.1177/2058738418812342 A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS Original Abstract A neuroinflammatory paradigm is presented to help explain the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The hypothalamic paraventricular nucleus (PVN) is responsible for absorbing and processing multiple, incoming and convergent ‘stress’ signals, and if this cluster of neurons were affected (by neuroinflammation), the ongoing hypersensitivity of ME/CFS patients to a wide range of ‘stressors’ could be explained. Neuroinflammation that was chronic and fluctuating, as ‘inflammatory-marker’ studies support, could reflect a dynamic change in the hypothalamic PVN’s threshold for managing incoming ‘stress’ signals. This may not only be a mechanism underpinning the characteristic feature of ME/CFS, post-exertional malaise, and its associated ...
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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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  The distinction between endogenous and exogenous retroviruses is often presented as a clear-cut biological fact, but making this determination is not always straightforward—and some arguments support the view that political, institutional, and even social factors play a significant role in where and how the line is drawn. Reasons why this classification can be political and is not always clear-cut: Definition Complexity: Endogenous retroviruses (ERVs) are viral sequences embedded in the germline DNA, inherited across generations, and mainly considered “old,” non-infectious remnants. Exogenous retroviruses are “external” viruses that infect individuals horizontally (from person to person or animal to animal). Yet, both are often nearly indistinguishable at the genetic level—sometimes a retrovirus can exist as both, or transition between the two categories over evolutionary time. Intermediate and Ambiguous Cases: Evidence suggests certain viruses classified as endogenous today were...
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HHV-6 and Male infertility (from Perplexity)

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  Make the case that HHV-6 may be responsible for the fertility problems in men Make the case that HHV-6 may be responsible for the fertility problems in men There is a growing body of evidence suggesting that Human Herpesvirus 6 (HHV-6) may play a role in male fertility problems. Here is the case based on recent research findings: Prevalence in Semen and Sperm Binding:  Studies have identified HHV-6A/B in approximately 13.5% of semen samples from healthy sperm donors, a prevalence higher than that of most other herpesviruses in semen. Importantly, HHV-6B has been shown to specifically bind to the acrosome—the cap-like structure on the head of sperm. This means that the virus can directly interact with sperm cells and potentially travel with them into the female reproductive tract. Potential Mechanisms of Fertility Impairment:  The binding of HHV-6 to the sperm acrosome suggests the existence of a receptor for the virus on sperm, raising the possibility that this interact...
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