Infection of porcine cells with human herpesviruses.

http://www.ncbi.nlm.nih.gov/pubmed/20692426

Abstract

Porcine organs are valuable candidate materials for xenotransplantation to humans. Long-term maintenance of well functioning transplants is a prerequisite for success. Transplanted organs may be damaged by immune reactions or by infectious agents in hosts. Human herpesviruses (HHVs) establish life-long latency in humans after a primary infection. They can be reactivated with various stimuli, including immunosuppression. This study was performed to verify the infectivity of some HHVs toward porcine cells. PK-15 cells infected with HHV-1 and HHV-2 showed cytopathology from 1 day after infection. Immunofluorescent (IF) staining of HHV-1- and HHV-2-infected PK-15 cells with respective antibodies demonstrated the expression of the respective viral antigens. Permissiveness of PK-15 to HHV-1 and -2 was confirmed by an infection test on Vero cells. Islet cells infected with HHV-5 showed no gross morphologic changes during the experimental course. A limited portion of islet cells reacted only to anti-IE1 and anti-IE2, but not to anti-UL44 or anti-gB antibody by IF staining, whereas a small portion of endothelial cells reacted to anti-IEs and anti-UL44, but not to anti-gB antibody. HHV-1 and -2 can permissively infect porcine cells, but HHV-5 infects a small proportion of cells with limited viral protein expression. HHV-4 could not transform peripheral blood mononuclear cells from miniature pigs. Collectively, because some HHVs can infect and damage porcine cells or impair their functions, HHVs should be cautiously monitored and controlled in humans when porcine cells or organs are transplanted to human beings.

Popular Posts in the Last 7 Days

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

Is this the most important fact about HHV-6's origins?

Time for action on HHV-6! Please post and circulate:

If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event?

"Secondary infections are reportedly common in hospitalized, severely ill COVID-19 patients, encompassing between ~10%-30% of cases with much greater frequency in the ICU setting"

Why we may need psychovirologists in the Age of HHV-6/7/8

Is HHV-6 really "a ubiquitous, commensal and usually benign beta-herpesvirus"?

Popular Post in the Last 30 Days

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

CFS and HHV-6 books available on Kindle Unlimited

Bhupesh Prusty, Konnie Knox, and Brigitte Huber have done the most important research on HHV-6. Why is Huber's retroviral finding about HHV-6 being ignored????

""Summary: A new study in Scientific Reports concludes human herpesvirus 6 may impair the brain’s ability to repair itself in demylination diseases, such as multiple sclerosis. HHV-6 is the most common human herpes virus, with an estimated 80% of people being exposed to infection during childhood. Researchers found the virus produces a protein that can impair the ability of brain cells to repair damaged myelin.

Look at what Groq A.I. came up with for a plot for a novel that portrays HIV as a Ponzi scheme.

Popular Posts from the Last Year

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

Why HIV should be referred to as "a red herring."

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?