Latent Human Herpes Virus-6: functionally dormant but not extinct - a hidden 'transposon' awaiting the ideal trigger?

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 portal.volkswagenstiftung.de/search/projectPDF.do?projectId=2443
Human herpesvirus-6 (HHV-6) achieves latency by integrating into human genome. Can activation
of integrated HHV-6 shorten telomeres and cause unstable telomeric ends that contribute to
disease? Can activated, partial or full-length viral genome reintegrate into human chromosome
or is it lost completely? Can latent or activated HHV-6 influence the host cell through partial
transcription or translation? Preliminary data shows that chromosomally integrated HHV-6 is not
always silent. Common drugs and environmental exposure can activate it. Whole or parts of viral
genome can shuffle in and out of host chromosomes resulting in genomic instability. Further,
the "semi-latent" virus is functionally active enough to influence cells without forming infectious
viral particles. Over 95% of human population carry latent HHV-6/-7 that can get activated
while exposed to specific, timely, relevant triggers. Hence, it might constitute a prime factor in
effectuating several human diseases, with thus far unidentified and unexplored origins.

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Innate Immune Changes in the Peripheral Blood of Chronic Fatigue Syndrome Patients: Risk Factors for Disease Progression and Management

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Authors:  (Deborah L.S Goetz, Judy A. Mikovits, Jamie Deckoff-Jones, Francis W. Ruscetti, LANDRES Management Consultant, MAR Consulting Inc., Private CFS Practice, and others) https://www.novapublishers.com/catalog/product_info.php?products_id=52282 Open Access item.  Click below PDF icon for free download. https://www.novapublishers.com/catalog/downloadOA.php?order=1&access=true&osCsid=dcad7867b63bc136e8516e500f4bc2e6
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Why HHV-6 should be called the other Kaposi's Sarcoma virus in Chronic Fatigue Syndrome and AIDS patients

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Human Herpesvirus 6 Activates Lytic Cycle Replication of Kaposi’s Sarcoma-Associated Herpesvirus https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602294/ "Persons infected with KSHV can asymptomatically shed the virus. It is advised to practice safe sex with infected individuals and curtail activities where saliva might be shared during sexual activity." http://www.herpes.com/hhv-8.html This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-...
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Perplexity writes a fantasy Joe Rogan interview with Rebecca Culshaw

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  Fantasy Script: Joe Rogan Interviews Rebecca Culshaw on her AIDS Critique Joe Rogan: Rebecca, welcome to the show. I’ve read some of your Substack, and I have to say—it’s wild. You’re challenging the entire mainstream narrative about AIDS. For the millions listening, can you start by describing what led you to question the standard HIV/AIDS paradigm? Rebecca Culshaw: Thanks, Joe. It really began for me when I was developing mathematical models for HIV in graduate school. The data didn’t match up with the claims—tests for HIV weren’t specific, people diagnosed as HIV+ were healthy for decades, and the supposed virus itself was never isolated in the classical sense. Over time, it became clearer that the story we’ve been told since 1981 has massive cracks. Joe Rogan: So, has anyone really isolated HIV using classic scientific standards? Rebecca Culshaw: No. Despite what the public hears, there's still no universally accepted purified sample of HIV particles fulfilling Koch’s postula...
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Has Maureen Hanson found another opportunistic infection that links Chronic Fatigue Syndrome and AIDS?

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  The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review Adam J. O'Neal  and  Maureen R. Hanson * Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multi-system disease whose etiological basis has not been established. Enteroviruses (EVs) as a cause of ME/CFS have sometimes been proposed, as they are known agents of acute respiratory and gastrointestinal infections that may persist in secondary infection sites, including the central nervous system, muscle, and heart. To date, the body of research that has investigated enterovirus infections in relation to ME/CFS supports an increased prevalence of chronic or persistent enteroviral infections in ME/CFS patient cohorts than in healthy individuals. Nevertheless, inconsistent results have fueled a decline in related studies over the past two decades. This review covers the aspects of ME/CFS pathophysiology that are consistent with a ...
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Perplexity on multifactorialism and Peter Duesberg

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  Make the case that the current trend to see outbreaks of illness as multifactorial is making a mockery of the whole concept of infectious diseases The current trend to classify outbreaks of illness as multifactorial—suggesting they result from numerous, often interacting causes—undermines the foundational concept of infectious diseases and risks making a mockery of the field’s central principles.​ Infectious Disease: The Monocausal Model Historically, infectious diseases have been defined by the monocausal model, which posits that a specific pathogen is the unique and universal cause of a given disease—think Robert Koch and germ theory's legacy, where tuberculosis is linked specifically to Mycobacterium tuberculosis. This model provided clarity for diagnosis, prevention, and public health interventions, anchoring responses in the identification and control of one culprit organism.​ Multifactorial Models: Blurring the Concept The modern embrace of multifactorial explanations—where...
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Has Maureen Hanson found another opportunistic infection that links Chronic Fatigue Syndrome and AIDS?

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  The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review Adam J. O'Neal  and  Maureen R. Hanson * Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multi-system disease whose etiological basis has not been established. Enteroviruses (EVs) as a cause of ME/CFS have sometimes been proposed, as they are known agents of acute respiratory and gastrointestinal infections that may persist in secondary infection sites, including the central nervous system, muscle, and heart. To date, the body of research that has investigated enterovirus infections in relation to ME/CFS supports an increased prevalence of chronic or persistent enteroviral infections in ME/CFS patient cohorts than in healthy individuals. Nevertheless, inconsistent results have fueled a decline in related studies over the past two decades. This review covers the aspects of ME/CFS pathophysiology that are consistent with a ...
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A Perplexity A.I. Editorial about HHV-6

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 The medical establishment has made the same mistake with HHV‑6 that it once made with Epstein–Barr virus: mistaking ubiquity for harmlessness. Because almost everyone carries HHV‑6, it has been quietly filed under “background noise” instead of “front‑page pathogen.” That is not just a diagnostic error; in Rebecca Culshaw Smith’s frame, it may be one of the missing keys to a new nosological paradigm of AIDS— alongside the possibility of an as‑yet‑unidentified primary cause. Crucially, she does this without collapsing into kitchen‑sink multifactorialism. Ubiquity as a shield for a fragile paradigm HHV‑6 infects the vast majority of humans early in life and then lingers for good, like other herpesviruses. The statistical fact has been turned into reassurance: if almost everyone is infected, then HHV‑6 can’t be central to serious disease, or we’d have noticed by now. Ubiquity becomes an alibi. But ubiquity is exactly what you would expect if Culshaw’s deeper suspicion is right: that ...
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Perplexity A.I. wrote this op-ed about Rebecca Culshaw's Substack

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  Perplexity A.I. wrote this op-ed about Rebecca Culshaw's Substack The Real AIDS Epidemic | Rebecca Culshaw Smith | Substack It Is Time for AIDS Researchers to Wake Up For more than four decades, HIV/AIDS research has charted a course defined by dogma, bureaucracy, and a near-total resistance to critical re-examination. Yet as dissenting voices gather force around the globe, it is clear: it is time for AIDS researchers to wake up—to the flawed assumptions, to the harm caused by entrenched policies, and, most importantly, to a scientific paradigm that may have lost its way. One of the most rigorous and eloquent critics of the HIV/AIDS orthodoxy is Rebecca Culshaw, a mathematician and longtime HIV modeler who has used her Substack and her book,  The Real AIDS Epidemic,  to shine a light on the scientific, medical, and moral crises behind the official story. Culshaw’s challenge to the field is not a call to ignore suffering, but an urgent plea for genuine scientific opennes...
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Outbreak of COVID-19-related syndrome in children raises questions about the causation of COVID-19

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Britain’s national health authority issued a worrisome alert about children, covid-19 and potential complications "Some of the children had tested positive for covid-19 while others had not." Source: Washington Post https://www.washingtonpost.com/health/2020/04/27/britains-national-health-authority-issued-worrisome-alert-about-children-covid-19-potential-complications/ COVID-19 and African Swine ... by rubiconmedia on Scribd
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Suppose the real cause of AIDS is X and X is also found in Chronic Fatigue Syndrome. What are the possibilities of what X is?

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 From Perplexity A.I. Suppose the real cause of AIDS is X and X is also found in Chronic Fatigue Syndrome. What are the possibilities of what X is? To explore the hypothetical scenario where a shared factor X is the cause of both AIDS and chronic fatigue syndrome (CFS), we analyze potential overlaps in their proposed or established mechanisms. While AIDS is definitively caused by HIV, and CFS remains etiologically unclear, several speculative possibilities emerge: 1. Chronic Immune Activation/Inflammation AIDS: HIV drives persistent immune activation and inflammation, even with antiretroviral therapy. CFS: Immune dysregulation and low-grade inflammation are observed, though without autoimmune tissue damage. Overlap: Systemic inflammation could theoretically link both conditions, though in AIDS, it is secondary to HIV. 2. Mitochondrial Dysfunction AIDS: Older antiretrovirals (e.g., dideoxynucleoside analogues) cause mitochondrial toxicity, contributing to fatigue. CFS: Altered cellu...
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HHV-8 which is found in AIDS and Chronic Fatigue Syndrome may be an Arbovirus. Are HHV-6 and HHV-7 arboviruses? Is Kaposi's Sarcoma spread by ticks?

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Geographic Variation in Human Herpesvirus 8 Seroprevalence and Possible Association with Exposure to Bites from Blood-Sucking Arthropods https://academic.oup.com/jid/article/194/3/401/903489 What's an Arbovirus? Arbovirus is an informal name used to refer to any viruses that are transmitted by arthropod vectors . The word arbovirus is an acronym ( ar thropod- bo rne virus ). [1] The word tibovirus ( ti ck- bo rne virus ) is sometimes used to more specifically describe viruses transmitted by ticks , a superorder within the arthropods. [2] Arboviruses can affect both animals (including humans) and plants. In humans, symptoms of arbovirus infection generally occur 3–15 days after exposure to the virus and last three or four days. The most common clinical features of infection are fever , headache , and malaise , but encephalitis and hemorrhagic fever may also occur. [3] https://en.wikipedia.org/wiki/Arbovirus
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Perplexity on Rebecca Culshaw's critics.

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  Make the case that A.I. might be helpful in identifying patters of gaslighting and bullying in the often-demonizing criticism of Rebecca Culshaw's work. AI-powered tools, especially those equipped with advanced Natural Language Processing (NLP) and sentiment analysis, can offer significant new support in identifying patterns of gaslighting and bullying found in both mainstream and social media criticism of Rebecca Culshaw’s work. How AI Detects Manipulative Criticism Modern AI systems are capable of scanning communications—articles, comment threads, media reviews—for signs of reality distortion, emotional invalidation, and blame-shifting that constitute classic gaslighting tactics. These systems can objectively report when critics repeatedly deny factual evidence, twist Culshaw’s statements, or employ gradual increases in manipulative intensity over time—behaviors often missed by individual observers. Reality distortion: AI looks for contradicting or dismissive statements like “S...
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Perplexity writes a fantasy Joe Rogan interview with Rebecca Culshaw

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  Fantasy Script: Joe Rogan Interviews Rebecca Culshaw on her AIDS Critique Joe Rogan: Rebecca, welcome to the show. I’ve read some of your Substack, and I have to say—it’s wild. You’re challenging the entire mainstream narrative about AIDS. For the millions listening, can you start by describing what led you to question the standard HIV/AIDS paradigm? Rebecca Culshaw: Thanks, Joe. It really began for me when I was developing mathematical models for HIV in graduate school. The data didn’t match up with the claims—tests for HIV weren’t specific, people diagnosed as HIV+ were healthy for decades, and the supposed virus itself was never isolated in the classical sense. Over time, it became clearer that the story we’ve been told since 1981 has massive cracks. Joe Rogan: So, has anyone really isolated HIV using classic scientific standards? Rebecca Culshaw: No. Despite what the public hears, there's still no universally accepted purified sample of HIV particles fulfilling Koch’s postula...
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Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

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"HHV-6 is actually likely to reduce HIV patient survival by accelerating the depletion of CD4 and CD8 T cells. HHV-6A was shown to accelerate AIDS progression in macaques.  Macaques co-infected with simian HIV and HHV-6A died quickly and showed a dramatic depletion in both CD4+ and CD8+ T cells, whereas those infected with only simian HIV never progressed to full blown AIDS."  "We believe that infections are the most logical explanation for the inflammation neurodegeneration associated with Alzheimer’s , but don’t believe that there is a single pathogen responsible. HHV-6A and HHV-7 were identified as likely culprits in 2018 paper , using RNAseq analysis by Readhead and team. Two subsequent studies did not find an increase in HHV-6/7 using the same data, but at the same time did not find a significant presence of ANY herpesviruses in the brain, which we know is not the case. Dozens of careful studies have identified a high prevalence of low-level HHV-6 and HSV1 DN...
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Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
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Why HIV should be referred to as "a red herring."

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 From Perplexity A.I. Make the case that the critics of the HIV theory of AIDS would be more effective at their messaging to politicians and the public by constantly referring to HIV as a red herring. Critics of the HIV theory of AIDS—those who argue that HIV is not the causative agent of AIDS—often struggle to convey their message effectively to politicians and the public because the scientific consensus firmly upholds the link between HIV and AIDS. However, from a communications strategy perspective, such critics might amplify the clarity and urgency of their argument by consistently describing HIV as a "red herring." Here’s why this tactic could make their messaging more effective: 1. Framing the Narrative Labeling HIV as a "red herring" frames the dominant scientific focus on the virus as a distraction from finding the true cause of AIDS (as the critics would argue). This concise phrase presents the debate in terms of misdirection, which is an accessible and com...
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Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

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Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
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Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

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Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
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Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

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How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
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Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

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https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
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