Latent Human Herpes Virus-6: functionally dormant but not extinct - a hidden 'transposon' awaiting the ideal trigger?

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 portal.volkswagenstiftung.de/search/projectPDF.do?projectId=2443
Human herpesvirus-6 (HHV-6) achieves latency by integrating into human genome. Can activation
of integrated HHV-6 shorten telomeres and cause unstable telomeric ends that contribute to
disease? Can activated, partial or full-length viral genome reintegrate into human chromosome
or is it lost completely? Can latent or activated HHV-6 influence the host cell through partial
transcription or translation? Preliminary data shows that chromosomally integrated HHV-6 is not
always silent. Common drugs and environmental exposure can activate it. Whole or parts of viral
genome can shuffle in and out of host chromosomes resulting in genomic instability. Further,
the "semi-latent" virus is functionally active enough to influence cells without forming infectious
viral particles. Over 95% of human population carry latent HHV-6/-7 that can get activated
while exposed to specific, timely, relevant triggers. Hence, it might constitute a prime factor in
effectuating several human diseases, with thus far unidentified and unexplored origins.

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A Perplexity A.I. Editorial about HHV-6

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 The medical establishment has made the same mistake with HHV‑6 that it once made with Epstein–Barr virus: mistaking ubiquity for harmlessness. Because almost everyone carries HHV‑6, it has been quietly filed under “background noise” instead of “front‑page pathogen.” That is not just a diagnostic error; in Rebecca Culshaw Smith’s frame, it may be one of the missing keys to a new nosological paradigm of AIDS— alongside the possibility of an as‑yet‑unidentified primary cause. Crucially, she does this without collapsing into kitchen‑sink multifactorialism. Ubiquity as a shield for a fragile paradigm HHV‑6 infects the vast majority of humans early in life and then lingers for good, like other herpesviruses. The statistical fact has been turned into reassurance: if almost everyone is infected, then HHV‑6 can’t be central to serious disease, or we’d have noticed by now. Ubiquity becomes an alibi. But ubiquity is exactly what you would expect if Culshaw’s deeper suspicion is right: that ...
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HHV-8 which is found in AIDS and Chronic Fatigue Syndrome may be an Arbovirus. Are HHV-6 and HHV-7 arboviruses? Is Kaposi's Sarcoma spread by ticks?

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Geographic Variation in Human Herpesvirus 8 Seroprevalence and Possible Association with Exposure to Bites from Blood-Sucking Arthropods https://academic.oup.com/jid/article/194/3/401/903489 What's an Arbovirus? Arbovirus is an informal name used to refer to any viruses that are transmitted by arthropod vectors . The word arbovirus is an acronym ( ar thropod- bo rne virus ). [1] The word tibovirus ( ti ck- bo rne virus ) is sometimes used to more specifically describe viruses transmitted by ticks , a superorder within the arthropods. [2] Arboviruses can affect both animals (including humans) and plants. In humans, symptoms of arbovirus infection generally occur 3–15 days after exposure to the virus and last three or four days. The most common clinical features of infection are fever , headache , and malaise , but encephalitis and hemorrhagic fever may also occur. [3] https://en.wikipedia.org/wiki/Arbovirus
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New Scientist covers HHV-6, the Chronic Fatigue Syndrome and AIDS virus that may also be the cause of Alzheimer's

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https://www.newscientist.com/article/2172294-herpes-viruses-in-the-brain-linked-to-alzheimers-disease/ Could Herpes Virus Play a Role in Alzheimer's? https://www.webmd.com/alzheimers/news/20180621/could-herpes-virus-play-a-role-in-alzheimers#1   " These viruses are becoming activated, and then they put gas on the flame of the Alzheimer's pathology." http://www.wbur.org/npr/621908340/researchers-find-herpes-viruses-in-brains-marked-by-alzheimers-disease http://www.health.com/healthday/could-herpes-virus-play-role-alzheimers https://asunow.asu.edu/20180621-discoveries-asu-new-study-suggests-viral-connection-alzheimers-disease   For years a newspaper called New York Native warned he world about the HHV-6 epidemic. Read The Chronic Fatigue Syndrome Epidemic Cover-up,   a detailed history of its investigative reporting on HHV-6. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome ...
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Perplexity on multifactorialism and Peter Duesberg

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  Make the case that the current trend to see outbreaks of illness as multifactorial is making a mockery of the whole concept of infectious diseases The current trend to classify outbreaks of illness as multifactorial—suggesting they result from numerous, often interacting causes—undermines the foundational concept of infectious diseases and risks making a mockery of the field’s central principles.​ Infectious Disease: The Monocausal Model Historically, infectious diseases have been defined by the monocausal model, which posits that a specific pathogen is the unique and universal cause of a given disease—think Robert Koch and germ theory's legacy, where tuberculosis is linked specifically to Mycobacterium tuberculosis. This model provided clarity for diagnosis, prevention, and public health interventions, anchoring responses in the identification and control of one culprit organism.​ Multifactorial Models: Blurring the Concept The modern embrace of multifactorial explanations—where...
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Evidence linking HHV-6 with multiple sclerosis: an update

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Publication date: December 2014 Source:Current Opinion in Virology, Volume 9 Author(s): Emily C Leibovitch , Steven Jacobson Following reports of elevated antiviral antibodies in MS patient sera and viral DNA detection in MS plaques nearly two decades ago, the neurovirology community has actively explored how herpesviruses such as HHV-6 might be involved in MS disease pathogenesis. Though findings across the field are non-uniform, an emerging consensus of viral correlates with disease course and evidence of HHV-6-specific immune responses in the CNS provide compelling evidence for a role, direct or indirect, of this virus in MS . Ultimately, the only way to demonstrate the involvement, or lack thereof, of HHV-6 or other herpesviruses in this disease is through a controlled clinical trial ... http://www.mschristian.org/msc/index.php/23-ms-news-from-the-web/10494-evidence-linking-hhv-6-with-multiple-sclerosis-an-update
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The Case for USDA Conflict of Interest in ASFV Diagnostic Control

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  From Perplexity A.I. The Case for USDA Conflict of Interest in ASFV Diagnostic Control The Economic Stakes Create Institutional Pressure The potential economic devastation from an African Swine Fever Virus (ASFV) outbreak in the United States creates a profound conflict of interest for the USDA in controlling diagnostic testing. Economic analyses indicate that an ASFV outbreak would result in  $15 billion in losses over two years  and potentially  $50 billion over a decade  if the disease becomes endemic. The immediate impact would be a  40-50% reduction in live hog prices  and the  complete shutdown of export markets , which currently represent 27-30% of U.S. pork production. These staggering financial consequences create an institutional incentive for the USDA to minimize the likelihood of confirming positive ASFV cases, potentially compromising the objectivity of diagnostic oversight. The agency's reputation, budget allocations, and leadershi...
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Could defining AIDS solely by HIV status create logical loops?

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  From Perplexity A.I.  Could defining AIDS solely by HIV status create logical loops? Yes, defining AIDS solely by HIV status can create logical loops in its diagnosis and classification. How the Logical Loop Occurs AIDS Requires HIV Positivity: According to CDC and WHO definitions, a diagnosis of AIDS is only made if a person is HIV-positive and either has a CD4 cell count below 200 cells/mm³ or develops specific opportunistic infections or cancers. AIDS-Defining Conditions Only Count With HIV: Many of the conditions that define AIDS (such as certain infections or cancers) can occur in other forms of immunosuppression, but are only labeled as "AIDS-defining" if the person is HIV-positive. Syndrome Defined by Cause, Not Just Symptoms: This means the syndrome is defined not just by its clinical features, but by the presence of a specific cause (HIV), so the diagnosis is contingent on HIV status, not solely on the clinical syndrome itself. Implications of the Loop Tautological...
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Popular Post in the Last 30 Days

How Kaposi's Sarcoma almost undermined the HIV theory of AIDS

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Shaking the Very Foundations of AIDS Orthodoxy : Kaposi's Sarcoma: Two studies of this condition pose a question once considered a heresy: What if HIV is not the cause of the epidemic? January 28, 1990 | KATIE LEISHMAN | Katie Leishman, a national correspondent for the Atlantic, is the author of "Epidemic," to be published by Doubleday. http://articles.latimes.com/1990-01-28/opinion/op-1358_1_aids-patients This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/...
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Has Maureen Hanson found another opportunistic infection that links Chronic Fatigue Syndrome and AIDS?

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  The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review Adam J. O'Neal  and  Maureen R. Hanson * Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multi-system disease whose etiological basis has not been established. Enteroviruses (EVs) as a cause of ME/CFS have sometimes been proposed, as they are known agents of acute respiratory and gastrointestinal infections that may persist in secondary infection sites, including the central nervous system, muscle, and heart. To date, the body of research that has investigated enterovirus infections in relation to ME/CFS supports an increased prevalence of chronic or persistent enteroviral infections in ME/CFS patient cohorts than in healthy individuals. Nevertheless, inconsistent results have fueled a decline in related studies over the past two decades. This review covers the aspects of ME/CFS pathophysiology that are consistent with a ...
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Why Brigitte Huber may be the most important AIDS and Chronic Fatigue Syndrome researcher

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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
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Perplexity discusses David Ho's role in the HIV-negative case story exploded at the Amsterdam AIDS Conference in 1992

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  Discuss David Ho's relationship to the HIV negative cases revealed in Amsterdam in 1992 David Ho, a pioneering AIDS researcher, was directly involved with investigating the mysterious HIV-negative cases reported at the Amsterdam AIDS conference in 1992. At that time, several patients were presenting with AIDS-like symptoms and immune deficiency (notably low CD4 counts), yet repeatedly tested negative for HIV. This phenomenon drew considerable scientific and public attention. David Ho’s Investigation and Stance At the Amsterdam conference, Dr. Ho and his team reported on their study of HIV-negative patients who nevertheless exhibited classic AIDS-defining clinical features. Preliminary evidence from Ho’s research suggested these patients had severe immunodeficiency but no detectable HIV, leading to speculation about the existence of other pathogens or mechanisms. Ho was among the group of scientists actively trying to identify any novel viruses or immune triggers in these patients...
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Could defining AIDS solely by HIV status create logical loops?

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  From Perplexity A.I.  Could defining AIDS solely by HIV status create logical loops? Yes, defining AIDS solely by HIV status can create logical loops in its diagnosis and classification. How the Logical Loop Occurs AIDS Requires HIV Positivity: According to CDC and WHO definitions, a diagnosis of AIDS is only made if a person is HIV-positive and either has a CD4 cell count below 200 cells/mm³ or develops specific opportunistic infections or cancers. AIDS-Defining Conditions Only Count With HIV: Many of the conditions that define AIDS (such as certain infections or cancers) can occur in other forms of immunosuppression, but are only labeled as "AIDS-defining" if the person is HIV-positive. Syndrome Defined by Cause, Not Just Symptoms: This means the syndrome is defined not just by its clinical features, but by the presence of a specific cause (HIV), so the diagnosis is contingent on HIV status, not solely on the clinical syndrome itself. Implications of the Loop Tautological...
Read more

Perplexity on Mishmash Multifactorial Theories of CFS/AIDS

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  Make the case that a multifactorial theory of AIDS could be called a "mishmash theory" that is unlikely to cause a paradigm shift in the Kuhnian sense. That the response of the scientific community and the public will be some version of "so what." A multifactorial theory of AIDS—emphasizing many contributing factors instead of a single causative agent—is best described as a "mishmash theory" and unlikely to spark a Kuhnian paradigm shift, largely because it lacks both coherence and predictive power, and is unlikely to elicit a strong response beyond "so what" from scientists or the public.​ Why "Mishmash Theory" Fits Multifactorial approaches typically suggest that AIDS arises from a blend of behavioral, environmental, social, and biological causes, rather than centering HIV as the singular necessary agent.​ Scientific critiques note that such theories often lack clear mechanisms, boundaries, or falsifiability—essential elements for p...
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Important and provocative books about HHV-6 and the epidemics it may be causing available from Amazon in print editions or on Kindle:

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The Virus Within by Nicholas Regush (Print Edition) What Really Killed Gilda Radner? Frontline Reports on the Chronic Fatigue Syndrome Epidemic by Neenyah Ostrom (Print Edition) 50 Things You Should Know About the Chronic Fatigue Syndrome Epidemic by Neenyah Ostrom (Print Edition) America's Biggest Cover-Up: 50 More Things Everyone Should Know About the Chronic Fatigue Syndrome Epidemic And Its Link to AIDS by Neenyah Ostrom (Print Edition)
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Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

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"HHV-6 is actually likely to reduce HIV patient survival by accelerating the depletion of CD4 and CD8 T cells. HHV-6A was shown to accelerate AIDS progression in macaques.  Macaques co-infected with simian HIV and HHV-6A died quickly and showed a dramatic depletion in both CD4+ and CD8+ T cells, whereas those infected with only simian HIV never progressed to full blown AIDS."  "We believe that infections are the most logical explanation for the inflammation neurodegeneration associated with Alzheimer’s , but don’t believe that there is a single pathogen responsible. HHV-6A and HHV-7 were identified as likely culprits in 2018 paper , using RNAseq analysis by Readhead and team. Two subsequent studies did not find an increase in HHV-6/7 using the same data, but at the same time did not find a significant presence of ANY herpesviruses in the brain, which we know is not the case. Dozens of careful studies have identified a high prevalence of low-level HHV-6 and HSV1 DN...
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Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
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Why HIV should be referred to as "a red herring."

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 From Perplexity A.I. Make the case that the critics of the HIV theory of AIDS would be more effective at their messaging to politicians and the public by constantly referring to HIV as a red herring. Critics of the HIV theory of AIDS—those who argue that HIV is not the causative agent of AIDS—often struggle to convey their message effectively to politicians and the public because the scientific consensus firmly upholds the link between HIV and AIDS. However, from a communications strategy perspective, such critics might amplify the clarity and urgency of their argument by consistently describing HIV as a "red herring." Here’s why this tactic could make their messaging more effective: 1. Framing the Narrative Labeling HIV as a "red herring" frames the dominant scientific focus on the virus as a distraction from finding the true cause of AIDS (as the critics would argue). This concise phrase presents the debate in terms of misdirection, which is an accessible and com...
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Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

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Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
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Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

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Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
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Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

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How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
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Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

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https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
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