Latent Human Herpes Virus-6: functionally dormant but not extinct - a hidden 'transposon' awaiting the ideal trigger?

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 portal.volkswagenstiftung.de/search/projectPDF.do?projectId=2443
Human herpesvirus-6 (HHV-6) achieves latency by integrating into human genome. Can activation
of integrated HHV-6 shorten telomeres and cause unstable telomeric ends that contribute to
disease? Can activated, partial or full-length viral genome reintegrate into human chromosome
or is it lost completely? Can latent or activated HHV-6 influence the host cell through partial
transcription or translation? Preliminary data shows that chromosomally integrated HHV-6 is not
always silent. Common drugs and environmental exposure can activate it. Whole or parts of viral
genome can shuffle in and out of host chromosomes resulting in genomic instability. Further,
the "semi-latent" virus is functionally active enough to influence cells without forming infectious
viral particles. Over 95% of human population carry latent HHV-6/-7 that can get activated
while exposed to specific, timely, relevant triggers. Hence, it might constitute a prime factor in
effectuating several human diseases, with thus far unidentified and unexplored origins.

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The New York Native, April 15, 1996

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Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
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