GP96 Interacts with HHV-6 during Viral Entry and Directs It for Cellular Degradation

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" . . .this virus subverts innate immune signaling through engagement of different co-receptors that ultimately decide the fate of virus infection."
 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0113962

Wikipedia on The Innate Immune System
 http://en.wikipedia.org/wiki/Innate_immune_system

The innate immune system, also known as the nonspecific immune system and the first line of defense,[1] is a subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. This means that the cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host.[2] Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.
The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.[3]
The major functions of the vertebrate innate immune system include:
  • Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines
  • Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells
  • The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells
  • Activation of the adaptive immune system through a process known as antigen presentation
  • Acting as a physical and chemical barrier to infectious agents

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