Two of the most important sentences from the Agut article on HHV-6

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"The dysfunction of HHV-6-induced immune responses leading to autoimmune processes would involve not only specific T cell responses but also NK cell-mediated activation and killing (148). All these phenomena would converge to promote release of self antigens and polyclonal activation."


 Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections

Henri Agut    Pascale Bonnafous    Agnès Gautheret-Dejean

Clin Microbiol Rev. 2015 Apr;28(2):313-35. doi: 10.1128/CMR.00122-14.

 http://cmr.asm.org/content/28/2/313.full.pdf+html?ijkey=v5.FkAKXOuEoU&keytype=ref&siteid=asmjournals








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  The distinction between endogenous and exogenous retroviruses is often presented as a clear-cut biological fact, but making this determination is not always straightforward—and some arguments support the view that political, institutional, and even social factors play a significant role in where and how the line is drawn. Reasons why this classification can be political and is not always clear-cut: Definition Complexity: Endogenous retroviruses (ERVs) are viral sequences embedded in the germline DNA, inherited across generations, and mainly considered “old,” non-infectious remnants. Exogenous retroviruses are “external” viruses that infect individuals horizontally (from person to person or animal to animal). Yet, both are often nearly indistinguishable at the genetic level—sometimes a retrovirus can exist as both, or transition between the two categories over evolutionary time. Intermediate and Ambiguous Cases: Evidence suggests certain viruses classified as endogenous today were...
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