Two of the most important sentences from the Agut article on HHV-6

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"The dysfunction of HHV-6-induced immune responses leading to autoimmune processes would involve not only specific T cell responses but also NK cell-mediated activation and killing (148). All these phenomena would converge to promote release of self antigens and polyclonal activation."


 Laboratory and Clinical Aspects of Human Herpesvirus 6 Infections

Henri Agut    Pascale Bonnafous    Agnès Gautheret-Dejean

Clin Microbiol Rev. 2015 Apr;28(2):313-35. doi: 10.1128/CMR.00122-14.

 http://cmr.asm.org/content/28/2/313.full.pdf+html?ijkey=v5.FkAKXOuEoU&keytype=ref&siteid=asmjournals








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Research Suggests it Has One. Human Herpesvirus 6 Activates Lytic Cycle Replication of Kaposi’s Sarcoma-Associated Herpesvirus Chun Lu, Yi Zeng, Zan Huang, Li Huang, Chao Qian, Guixia Tang and Di Qin From the Department of Microbiology and Immunology,* Laboratory of Molecular Virology, and the Laboratory of Reproductive Medicine,{dagger} Nanjing Medical University, Nanjing, People’s Republic of China; and the Department of Cell Biology, Neurology, and Anatomy,{ddagger} Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois Kaposi’s sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is a {gamma}-herpesvirus consistently identified in Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman’s disease. KSHV infection appears to be necessary, but not be sufficient for development of KS without other co-factors. However, factors that facilitate KSHV to cause KS have not been well defined. Because patients with KS are ...
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Memo to CFS patients and CFS quacks: Let's get something straight.

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HHV-6 University Editorial Memo to CFS patients and CFS quacks: Please stop the bullshit about there being no symptoms like CFS in AIDS patients "Fatigue is a general term used to describe feelings of exhaustion, sleepiness, and lack of energy. It is a common problem among HIV-infected people. Fatigue is not a disease, but rather a symptom of disease. Some people suffer from isolated or periodic bouts of exhaustion. Others, however, experience chronic fatigue, which may greatly interfere with work or other day-to-day activities."  https://www.poz.com/basics/hiv-basics/feeling-tired-fatigue-anemia     Previous HHV-6 University Editorials August 6, 2016 HHV-6 University Editorial The Mary Schweitzer CFS Biomarker One cannot fault suffering Chronic Fatigue Syndrome patients for adopting a pragmatic attitude toward their dire situation. They pray every day for "something, anything" that will make them better. But unfortunately, there is somethi...
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HHV-8 and KS in CFIDS

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A number of years ago, Neenyah Ostrom reported in the New York Native on the lesions in CFS patients which seem to resemble Kaposi's Sarcoma (KS). The current thinking is that a virus called HHV-8 is the cause of KS. (Although HHV-6 has recently also been implicated once again.) If KS is a problem in CFS (and we suspect it is) then one should be able to find HHV-8 and HHV-6 in CFS patients. Apparently, in this small study, one can. Below is a rather explosive abstract: Prevalence in the cerebrospinal fluid of the following infectious agents in a cohort of 12 CFS subjects: human herpes virus-6 and 8; chlamydia species; mycoplasma species; EBV; CMV; and Coxsackievirus. Levine, S. Journal of Chronic Fatigue Syndrome, 2001, 9, 1/2, 41-51. Abstract: Over the last decade a wide variety of infectious agents have been associated with the CFS as potential etiologies for this disorder. Many of these agents are neurotrophic and have been linked previously to other diseas...
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Important and provocative books about HHV-6 and the epidemics it may be causing available from Amazon in print editions or on Kindle:

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The Virus Within by Nicholas Regush (Print Edition) What Really Killed Gilda Radner? Frontline Reports on the Chronic Fatigue Syndrome Epidemic by Neenyah Ostrom (Print Edition) 50 Things You Should Know About the Chronic Fatigue Syndrome Epidemic by Neenyah Ostrom (Print Edition) America's Biggest Cover-Up: 50 More Things Everyone Should Know About the Chronic Fatigue Syndrome Epidemic And Its Link to AIDS by Neenyah Ostrom (Print Edition)
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When will the media ask Fauci about the Kaposi's Sarcoma epidemic in Chronic Fatigue Syndrome patients?

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Everything you wanted to know about Kaposi’s Sarcoma in Chronic Fatigue Syndrome patients and the growing CFS epidemic of HHV-8, one of the two or three viruses that may be causing Kaposi’s Sarcoma. Excerpted from The Chronic Fatigue Syndrome Epidemic Cover-up , a bestseller on Amazon.      Neenyah Ostrom began one of my favorite series of articles in the same issue. Titled “The Color Purple,” Ostrom reported, “Burke Cunha, M.D. who is chief of infectious disease at Winthrop-University Hospital (Mineola, Long Island), has described what he calls ‘crimson crescents’ that appear in the throats of more than 80 percent of chronic fatigue syndrome (CFS) patients. Cunha describes the crescents not only as ‘crimson,’ but ‘purplish.’ The reddish-purplish regions found in CFS patients’ throats sounded quite similar to KS (Kaposi’s sarcoma) in the throat, commented an ‘AIDS’ doctor [who wished to remain anonymous] to whom they were described. Is it po...
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The Price of CDC/NIH/Fauci's HHV-6 Indifference

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Congenital herpes tied to lower developmental test scores in infants Infants with congenital human herpesvirus-6 (HHV-6) infections are more likely to score lower on a 12-month mental development test, according to a new URMC study published in the journal Pediatrics . http://medicalxpress.com/news/2014-11-congenital-herpes-tied-developmental-scores.html Early Developmental Outcomes of Children With Congenital HHV-6 Infection CONCLUSIONS: Congenital HHV-6 infection may have a detrimental effect on neurodevelopment at 12 months of age and requires further study given that congenital infection with HHV-6 is present in ∼1 in every 101 births.  http://pediatrics.aappublications.org/content/early/2014/10/29/peds.2014-0886.abstract HHV-6 and Autism In most cases, “autism” like behaviors are caused by the break down of the child’s immune system; allowing viruses, candida, fungi and parasites to set up shop in our beautiful children’s body a...
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John Beldekas and HHV-6

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In August, 1986, John Beldekas was invited to go to the NCI and present his findings on the link between ASFV [African Swine Fever virus] and AIDS, which he did. Beldekas gave samples of all his lab work to Gallo. Later, the government asked Beldekas to turn over all his reagents and lab work to the government, which he did. Beldekas had found ASFV presence in nine of 21 AIDS patients using two standard procedures. At the meeting, Gallo was reported saying: “we know it is not ASFV.” How could Gallo know this as he hadn’t done any of his own tests to look for ASFV? Two months later, Gallo published an article in Science (Oct 31, 1986) that he discovered a new possible co-factor in AIDS, a virus he called Human B Cell Lymphotropic Virus which he named HBLV. Like ASFV, HBLV infected B cells and also lived in macrophages. Did Gallo steal Beldekas’s ASF virus he found in AIDS patients and rename it HBLV? Later on, when Gallo found that HBLV could also infect other immune cel...
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Memo to CFS patients and CFS quacks: Let's get something straight.

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From Perplexity: Here are 20 ways the pharmaceutical industry should reorient their AIDS efforts based on Rebecca Culshaw’s Substack critique of the HIV paradigm:

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From Perplexity A.I.: List 20 questions that would make the HIV establishment (which has demonized critics of the HIV theory) uncomfortable.

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  Discuss the issue of K.S. happening despite ART use Kaposi sarcoma (KS) can and does occur in people living with HIV, even when they are on effective antiretroviral therapy (ART). While ART has dramatically reduced the incidence and severity of KS, several important points explain why KS still happens despite ART use: Immune Reconstitution Inflammatory Syndrome (IRIS): Some individuals develop KS or see it worsen shortly after starting ART, in what is known as KS-IRIS. This is thought to be due to immune system recovery leading to a paradoxical inflammatory response, which can unmask or exacerbate KS—even when HIV viral load drops and CD4 counts begin to rise. Rapidly disseminated or aggressive KS has been reported in these cases, sometimes within months of starting ART. Persistent Risk Despite Good Immune Recovery: Studies have documented cases of KS in patients who maintain undetectable HIV viral loads and normal CD4 counts for years. This includes long-term HIV survivors and o...
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How Kaposi's Sarcoma almost undermined the HIV theory of AIDS

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Shaking the Very Foundations of AIDS Orthodoxy : Kaposi's Sarcoma: Two studies of this condition pose a question once considered a heresy: What if HIV is not the cause of the epidemic? January 28, 1990 | KATIE LEISHMAN | Katie Leishman, a national correspondent for the Atlantic, is the author of "Epidemic," to be published by Doubleday. http://articles.latimes.com/1990-01-28/opinion/op-1358_1_aids-patients This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/...
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When will the media ask Fauci about the Kaposi's Sarcoma epidemic in Chronic Fatigue Syndrome patients?

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Image
Everything you wanted to know about Kaposi’s Sarcoma in Chronic Fatigue Syndrome patients and the growing CFS epidemic of HHV-8, one of the two or three viruses that may be causing Kaposi’s Sarcoma. Excerpted from The Chronic Fatigue Syndrome Epidemic Cover-up , a bestseller on Amazon.      Neenyah Ostrom began one of my favorite series of articles in the same issue. Titled “The Color Purple,” Ostrom reported, “Burke Cunha, M.D. who is chief of infectious disease at Winthrop-University Hospital (Mineola, Long Island), has described what he calls ‘crimson crescents’ that appear in the throats of more than 80 percent of chronic fatigue syndrome (CFS) patients. Cunha describes the crescents not only as ‘crimson,’ but ‘purplish.’ The reddish-purplish regions found in CFS patients’ throats sounded quite similar to KS (Kaposi’s sarcoma) in the throat, commented an ‘AIDS’ doctor [who wished to remain anonymous] to whom they were described. Is it po...
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Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

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  Rebecca Culshaw’s Substack articles establish a foundation for arguing that the mass promotion and use of PrEP (pre-exposure prophylaxis) in HIV prevention could be considered a form of “genocide,” rooted in several lines of critique that challenge both the scientific and ethical underpinnings of the intervention. ​ Critique of Efficacy Claims Culshaw repeatedly questions the reliability of the efficacy data cited for PrEP, especially the widely publicized claim of “99% effectiveness.” She critiques the primary studies behind this figure, particularly the UK “Impact Trial,” highlighting that its actual observed efficacy was only 86%, and that even this figure is derived from retrospective, less scientifically rigorous analysis. She emphasizes that PrEP, to justify the aggressive and potentially coercive marketing campaigns behind it, should meet a much higher bar of evidence given its target population often consists of healthy individuals. By questioning what she perceives as st...
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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
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From Perplexity A.I.: A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences.

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  A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences. Scale and Impact of AIDS The way AIDS was defined and classified determined how millions of people were diagnosed, treated, and socially perceived. Nosological mistakes have led to unnecessary suffering, stigmatization, discrimination, and sometimes fatal outcomes for entire populations. During the early epidemic, AIDS definitions dictated global policies, resource allocation, and public health strategies, impacting the lives of marginalized groups and shaping health systems globally. Misdirected Interventions and Suffering If the nosology—such as equating all immune compromise with AIDS or failing to recognize other causes—was incorrect, countless lives may have been lost or damaged due to misdiagnosis, inappropriate tre...
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Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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How Kaposi's Sarcoma almost undermined the HIV theory of AIDS

-
Image
Shaking the Very Foundations of AIDS Orthodoxy : Kaposi's Sarcoma: Two studies of this condition pose a question once considered a heresy: What if HIV is not the cause of the epidemic? January 28, 1990 | KATIE LEISHMAN | Katie Leishman, a national correspondent for the Atlantic, is the author of "Epidemic," to be published by Doubleday. http://articles.latimes.com/1990-01-28/opinion/op-1358_1_aids-patients This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/...
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A Perplexity conversation about self-deceit, conspiracy, Arendt and AIDS

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  Discuss the confusion between the appearance of conspiracy and self-deceit, and how self-deceit in government leaders creates the appearance of conspiracy. Self-deceit in government leaders can powerfully create the appearance of conspiracy, even when there is no coordinated secret plot. When leaders convince themselves of the righteousness or effectiveness of their own policies, they may unconsciously deny evidence of harm, ignore ethical contradictions, or adopt comforting narratives rather than confront uncomfortable truths. Other observers, detecting this disconnect between official statements and lived reality, may then perceive hidden motives, deliberate cover-ups, or coordinated deception—classic ingredients of conspiracy suspicions—even if the real dynamic is psychological denial and bureaucratic inertia. ​ This confusion arises because self-deceit can mimic true conspiracy: it generates secrecy, ritualized language, and the concealment of damaging realities, not by inten...
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