Is HHV-6 altering the mitochondria in NK lymphocytes of Chronic Fatigue Syndrome patients?


Mitochondrial alterations in NK lymphocytes from ME/CFS patients

"Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease characterized by profound fatigue, flu-like symptoms, trouble concentrating, and autonomic problems, all of which worsen after exertion. ME/CFS patients have impaired natural killer (NK) cell activity. NK lymphocytes are a critical first defense against viruses and cancer. ME/CFS patients have difficulties controlling viral infections and many develop non-Hodgkin’s lymphoma. Mitochondrial metabolism is crucial for immune cell function. Mitochondria dysfunction has been previously reported in ME/CFS, but it is not known whether the NK cells of these patients have altered mitochondrial metabolism that affect their activity and contribute to ME/CFS pathogenesis. More importantly, there is currently no efficient method to diagnose ME/CFS or assess efficacy of therapeutic interventions. The Bioenergetic Health Index (BHI) has been developed as promising and reliable surrogate readout of human health by measuring the bioenergetic status of immune cells. Variations in bioenergetic function in patient’s immune cells can reflect both metabolic stress and the mutable role of these cells in ME/CFS immunity and pathogenesis. In our study, we observed that the two main energy-generating mitochondrial pathways, oxidative phosphorylation and glycolysis (bioenergetics parameters), are deregulated in ME/CFS NK cells and in PBMCs. Moreover, we observed alterations in the morphology and membrane potential of the mitochondria of NK cells. These mitochondrial features can affect NK cell function and contribute to the severity of disease. To date, this is the first metabolism assessment of NK cells in ME/CFS and as potential new diagnostic tool for the disease."

https://www.jimmunol.org/content/202/1_Supplement/126.39

Popular Posts in the Last 7 Days

Dr. Richard Podell on HHV-6

The gerrymandering of AIDS inflammation

How did 50% of Chronic Fatigue Syndrome patients become infected with a cancer virus?

Bulletin #109 from the Coordinating Committee of The International HHV-6 Protest and Teach-in at Harvard (November 9-11, 2015)

We asked GROQ to construct a debate about whether HIV is endogenous. Here is what it gave us.

Do financial markets know that HHV-8, the KS virus, might be African Swine Fever?

Popular Post in the Last 30 Days

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

Perplexity was asked to develop a concept of "policed gratitude" or "enforced gratitude" that has been imposed on AIDS patients to keep them in line and believing all the public health directions they are given.

Perplexity on the circular nature of HIV logic

Perplexity A.I. on "Duesberg Derangement Syndrome"

Perplexity A.I makes the case that in science and medicine we have moved on from the Age of Causation to the Age of Kitchensinkism versus Sine Qua Nonism.

Could Jordan Peterson and his daughter become Chronic Fatigue Syndrome and HHV-6 activists?

Perplexity A.I. on David Ho and HIV as an in silico Ponzi scheme

Popular Posts from the Last Year

Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Why HIV should be referred to as "a red herring."

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

Dr. Rebecca Culshaw Smith's book is discussed on Twitter

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?