Is HHV-6 altering the mitochondria in NK lymphocytes of Chronic Fatigue Syndrome patients?

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Mitochondrial alterations in NK lymphocytes from ME/CFS patients

"Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease characterized by profound fatigue, flu-like symptoms, trouble concentrating, and autonomic problems, all of which worsen after exertion. ME/CFS patients have impaired natural killer (NK) cell activity. NK lymphocytes are a critical first defense against viruses and cancer. ME/CFS patients have difficulties controlling viral infections and many develop non-Hodgkin’s lymphoma. Mitochondrial metabolism is crucial for immune cell function. Mitochondria dysfunction has been previously reported in ME/CFS, but it is not known whether the NK cells of these patients have altered mitochondrial metabolism that affect their activity and contribute to ME/CFS pathogenesis. More importantly, there is currently no efficient method to diagnose ME/CFS or assess efficacy of therapeutic interventions. The Bioenergetic Health Index (BHI) has been developed as promising and reliable surrogate readout of human health by measuring the bioenergetic status of immune cells. Variations in bioenergetic function in patient’s immune cells can reflect both metabolic stress and the mutable role of these cells in ME/CFS immunity and pathogenesis. In our study, we observed that the two main energy-generating mitochondrial pathways, oxidative phosphorylation and glycolysis (bioenergetics parameters), are deregulated in ME/CFS NK cells and in PBMCs. Moreover, we observed alterations in the morphology and membrane potential of the mitochondria of NK cells. These mitochondrial features can affect NK cell function and contribute to the severity of disease. To date, this is the first metabolism assessment of NK cells in ME/CFS and as potential new diagnostic tool for the disease."

https://www.jimmunol.org/content/202/1_Supplement/126.39

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Research Suggests it Has One. Human Herpesvirus 6 Activates Lytic Cycle Replication of Kaposi’s Sarcoma-Associated Herpesvirus Chun Lu, Yi Zeng, Zan Huang, Li Huang, Chao Qian, Guixia Tang and Di Qin From the Department of Microbiology and Immunology,* Laboratory of Molecular Virology, and the Laboratory of Reproductive Medicine,{dagger} Nanjing Medical University, Nanjing, People’s Republic of China; and the Department of Cell Biology, Neurology, and Anatomy,{ddagger} Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois Kaposi’s sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is a {gamma}-herpesvirus consistently identified in Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman’s disease. KSHV infection appears to be necessary, but not be sufficient for development of KS without other co-factors. However, factors that facilitate KSHV to cause KS have not been well defined. Because patients with KS are ...
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Today Only!

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We're giving away five Kindle copies of The Chronic Fatigue Syndrome Epidemic Cover-up to the first five people in the USA who accept them here: https://www.amazon.com/ga/p/5ae212d43bae8e79
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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
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From Perplexity A.I.: A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences.

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  A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences. Scale and Impact of AIDS The way AIDS was defined and classified determined how millions of people were diagnosed, treated, and socially perceived. Nosological mistakes have led to unnecessary suffering, stigmatization, discrimination, and sometimes fatal outcomes for entire populations. During the early epidemic, AIDS definitions dictated global policies, resource allocation, and public health strategies, impacting the lives of marginalized groups and shaping health systems globally. Misdirected Interventions and Suffering If the nosology—such as equating all immune compromise with AIDS or failing to recognize other causes—was incorrect, countless lives may have been lost or damaged due to misdiagnosis, inappropriate tre...
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Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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How Kaposi's Sarcoma almost undermined the HIV theory of AIDS

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Image
Shaking the Very Foundations of AIDS Orthodoxy : Kaposi's Sarcoma: Two studies of this condition pose a question once considered a heresy: What if HIV is not the cause of the epidemic? January 28, 1990 | KATIE LEISHMAN | Katie Leishman, a national correspondent for the Atlantic, is the author of "Epidemic," to be published by Doubleday. http://articles.latimes.com/1990-01-28/opinion/op-1358_1_aids-patients This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/...
Read more

A Perplexity conversation about self-deceit, conspiracy, Arendt and AIDS

-
  Discuss the confusion between the appearance of conspiracy and self-deceit, and how self-deceit in government leaders creates the appearance of conspiracy. Self-deceit in government leaders can powerfully create the appearance of conspiracy, even when there is no coordinated secret plot. When leaders convince themselves of the righteousness or effectiveness of their own policies, they may unconsciously deny evidence of harm, ignore ethical contradictions, or adopt comforting narratives rather than confront uncomfortable truths. Other observers, detecting this disconnect between official statements and lived reality, may then perceive hidden motives, deliberate cover-ups, or coordinated deception—classic ingredients of conspiracy suspicions—even if the real dynamic is psychological denial and bureaucratic inertia. ​ This confusion arises because self-deceit can mimic true conspiracy: it generates secrecy, ritualized language, and the concealment of damaging realities, not by inten...
Read more

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