New research with implications for CFS/AIDS

-

 

Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi’s sarcoma development



Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of several human cancers such as Kaposi’s sarcoma (KS), which represents the most common AIDS-associated malignancy that lacks effective treatment options. Despite its clear role in AIDS malignancies, the fact that only a small set of KSHV-infected patients will eventually develop these tumors implies that additional co-factors are required for the development of KSHV-related cancers. In the current study, we demonstrate for the first time that KSHV de novo infection or viral latent proteins are able to transactivate human endogenous retrovirus K (HERV-K) through a variety of cellular signaling pathways and transcriptional factors. Moreover, we found that HERV-K transactivation, particularly activation of its encoded oncogenic NP9 protein, plays an important role in KSHV pathogenesis and tumorigenesis in vitro and in vivo. Our data provide innovative insights into the mechanisms of HERV-K transactivation contributing to viral oncogenesis, which may represent a promising target for KS treatment.

Popular Posts in the Last 7 Days

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

-
  Rebecca Culshaw’s Substack articles establish a foundation for arguing that the mass promotion and use of PrEP (pre-exposure prophylaxis) in HIV prevention could be considered a form of “genocide,” rooted in several lines of critique that challenge both the scientific and ethical underpinnings of the intervention. ​ Critique of Efficacy Claims Culshaw repeatedly questions the reliability of the efficacy data cited for PrEP, especially the widely publicized claim of “99% effectiveness.” She critiques the primary studies behind this figure, particularly the UK “Impact Trial,” highlighting that its actual observed efficacy was only 86%, and that even this figure is derived from retrospective, less scientifically rigorous analysis. She emphasizes that PrEP, to justify the aggressive and potentially coercive marketing campaigns behind it, should meet a much higher bar of evidence given its target population often consists of healthy individuals. By questioning what she perceives as st...
Read more

A Perplexity conversation about self-deceit, conspiracy, Arendt and AIDS

-
  Discuss the confusion between the appearance of conspiracy and self-deceit, and how self-deceit in government leaders creates the appearance of conspiracy. Self-deceit in government leaders can powerfully create the appearance of conspiracy, even when there is no coordinated secret plot. When leaders convince themselves of the righteousness or effectiveness of their own policies, they may unconsciously deny evidence of harm, ignore ethical contradictions, or adopt comforting narratives rather than confront uncomfortable truths. Other observers, detecting this disconnect between official statements and lived reality, may then perceive hidden motives, deliberate cover-ups, or coordinated deception—classic ingredients of conspiracy suspicions—even if the real dynamic is psychological denial and bureaucratic inertia. ​ This confusion arises because self-deceit can mimic true conspiracy: it generates secrecy, ritualized language, and the concealment of damaging realities, not by inten...
Read more

All these mistakes have been made in AIDS and they have led to the Chronic Fatigue Syndrome epidemic

-
Image
It's time for scientists to acknowledge the epidemiological mistakes that led to the HHV-6 and Chronic Fatigue Syndrome epidemic. Seven mistakes and potential solutions in epidemiology, including a call for a World Council of Epidemiology and Causality https://ete-online.biomedcentral.com/articles/10.1186/1742-7622-6-6 All the mistakes in AIDS epidemiology led to the disaster described in this book.  Now an audiobook! On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.              ...
Read more

Why Brigitte Huber may be the most important AIDS and Chronic Fatigue Syndrome researcher

-
Image
  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
Read more

A moment of truth every intellectual and scientist in France, Europe and Russia should be aware of!

-
A revealing moment in the Montagnier-Agut HIV Fraud Ponzi Scheme and HHV-6 Cover-up: In 1988 I was working as a consultant at Specialty Labs in Santa Monica, setting up analytic routines for the Human Immunodeficiency Virus (HIV). I knew a lot about setting up analytic routines for anything with nucleic acids in it because I had invented the Polymerase Chain Reaction. That's why they had hired me. Acquired Immune Deficiency Syndrome (AIDS), on the other hand, was something I did not know a lot about. Thus, when I found myself writing a report on our progress and goals for the project, sponsored by the National Institutes of Health, I recog nized that I did not know the scientific reference to support a statement I had just written: "HIV is the probable cause of AIDS." So I turned to the virologist at the next desk, a reliable and competent fellow, and asked him for the reference. He said I didn't need one. I disagreed. While it's true that certain scientific...
Read more

Is Chronic Fatigue Syndrome Associated Kaposi's Sarcoma (CFSKS) a diagnosis all doctors should become aware of?

-
Image
Another HHV-8- associated condition, the KSHV inflammatory cytokine syndrome (KICS ), has been more recently described. 48-50 Patients with this syndrome display MCD-like inflammatory symptoms, but do not have pathological findings of MCD. Patients with KICS are frequently critically ill and demonstrate marked elevations in IL-6 and IL-10, as well as high plasma HHV-8 viral loads. KICS may contribute to the inflammatory symptoms seen in some patients with severe KS or PEL, and there may be significant clinical overlap between these conditions.  https://aidsinfo.nih.gov/guidelines/html/4/adult-and-adolescent-opportunistic-infection/342/hhv-8 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTRACT Over the last decade a wide variety of infectious agents has been associated w...
Read more

Popular Post in the Last 30 Days

Memo to CFS patients and CFS quacks: Let's get something straight.

-
Image
HHV-6 University Editorial Memo to CFS patients and CFS quacks: Please stop the bullshit about there being no symptoms like CFS in AIDS patients "Fatigue is a general term used to describe feelings of exhaustion, sleepiness, and lack of energy. It is a common problem among HIV-infected people. Fatigue is not a disease, but rather a symptom of disease. Some people suffer from isolated or periodic bouts of exhaustion. Others, however, experience chronic fatigue, which may greatly interfere with work or other day-to-day activities."  https://www.poz.com/basics/hiv-basics/feeling-tired-fatigue-anemia     Previous HHV-6 University Editorials August 6, 2016 HHV-6 University Editorial The Mary Schweitzer CFS Biomarker One cannot fault suffering Chronic Fatigue Syndrome patients for adopting a pragmatic attitude toward their dire situation. They pray every day for "something, anything" that will make them better. But unfortunately, there is somethi...
Read more

A Perplexity conversation about self-deceit, conspiracy, Arendt and AIDS

-
  Discuss the confusion between the appearance of conspiracy and self-deceit, and how self-deceit in government leaders creates the appearance of conspiracy. Self-deceit in government leaders can powerfully create the appearance of conspiracy, even when there is no coordinated secret plot. When leaders convince themselves of the righteousness or effectiveness of their own policies, they may unconsciously deny evidence of harm, ignore ethical contradictions, or adopt comforting narratives rather than confront uncomfortable truths. Other observers, detecting this disconnect between official statements and lived reality, may then perceive hidden motives, deliberate cover-ups, or coordinated deception—classic ingredients of conspiracy suspicions—even if the real dynamic is psychological denial and bureaucratic inertia. ​ This confusion arises because self-deceit can mimic true conspiracy: it generates secrecy, ritualized language, and the concealment of damaging realities, not by inten...
Read more

Is Chronic Fatigue Syndrome Associated Kaposi's Sarcoma (CFSKS) a diagnosis all doctors should become aware of?

-
Image
Another HHV-8- associated condition, the KSHV inflammatory cytokine syndrome (KICS ), has been more recently described. 48-50 Patients with this syndrome display MCD-like inflammatory symptoms, but do not have pathological findings of MCD. Patients with KICS are frequently critically ill and demonstrate marked elevations in IL-6 and IL-10, as well as high plasma HHV-8 viral loads. KICS may contribute to the inflammatory symptoms seen in some patients with severe KS or PEL, and there may be significant clinical overlap between these conditions.  https://aidsinfo.nih.gov/guidelines/html/4/adult-and-adolescent-opportunistic-infection/342/hhv-8 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTRACT Over the last decade a wide variety of infectious agents has been associated w...
Read more

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

-
  Rebecca Culshaw’s Substack articles establish a foundation for arguing that the mass promotion and use of PrEP (pre-exposure prophylaxis) in HIV prevention could be considered a form of “genocide,” rooted in several lines of critique that challenge both the scientific and ethical underpinnings of the intervention. ​ Critique of Efficacy Claims Culshaw repeatedly questions the reliability of the efficacy data cited for PrEP, especially the widely publicized claim of “99% effectiveness.” She critiques the primary studies behind this figure, particularly the UK “Impact Trial,” highlighting that its actual observed efficacy was only 86%, and that even this figure is derived from retrospective, less scientifically rigorous analysis. She emphasizes that PrEP, to justify the aggressive and potentially coercive marketing campaigns behind it, should meet a much higher bar of evidence given its target population often consists of healthy individuals. By questioning what she perceives as st...
Read more

Why Brigitte Huber may be the most important AIDS and Chronic Fatigue Syndrome researcher

-
Image
  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
Read more

Today Only!

-
Image
We're giving away five Kindle copies of The Chronic Fatigue Syndrome Epidemic Cover-up to the first five people in the USA who accept them here: https://www.amazon.com/ga/p/5ae212d43bae8e79
Read more

Popular Posts from the Last Year

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

-
  Rebecca Culshaw’s Substack articles establish a foundation for arguing that the mass promotion and use of PrEP (pre-exposure prophylaxis) in HIV prevention could be considered a form of “genocide,” rooted in several lines of critique that challenge both the scientific and ethical underpinnings of the intervention. ​ Critique of Efficacy Claims Culshaw repeatedly questions the reliability of the efficacy data cited for PrEP, especially the widely publicized claim of “99% effectiveness.” She critiques the primary studies behind this figure, particularly the UK “Impact Trial,” highlighting that its actual observed efficacy was only 86%, and that even this figure is derived from retrospective, less scientifically rigorous analysis. She emphasizes that PrEP, to justify the aggressive and potentially coercive marketing campaigns behind it, should meet a much higher bar of evidence given its target population often consists of healthy individuals. By questioning what she perceives as st...
Read more

Why Brigitte Huber may be the most important AIDS and Chronic Fatigue Syndrome researcher

-
Image
  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
Read more

From Perplexity A.I.: A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences.

-
  A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences. Scale and Impact of AIDS The way AIDS was defined and classified determined how millions of people were diagnosed, treated, and socially perceived. Nosological mistakes have led to unnecessary suffering, stigmatization, discrimination, and sometimes fatal outcomes for entire populations. During the early epidemic, AIDS definitions dictated global policies, resource allocation, and public health strategies, impacting the lives of marginalized groups and shaping health systems globally. Misdirected Interventions and Suffering If the nosology—such as equating all immune compromise with AIDS or failing to recognize other causes—was incorrect, countless lives may have been lost or damaged due to misdiagnosis, inappropriate tre...
Read more

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
Read more

How Kaposi's Sarcoma almost undermined the HIV theory of AIDS

-
Image
Shaking the Very Foundations of AIDS Orthodoxy : Kaposi's Sarcoma: Two studies of this condition pose a question once considered a heresy: What if HIV is not the cause of the epidemic? January 28, 1990 | KATIE LEISHMAN | Katie Leishman, a national correspondent for the Atlantic, is the author of "Epidemic," to be published by Doubleday. http://articles.latimes.com/1990-01-28/opinion/op-1358_1_aids-patients This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/...
Read more

If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event?

-
 From Perplexity A.I.  If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event? If the scientific establishment were to fundamentally revise the current understanding of AIDS and declare that HIV is not the cause, this would indeed constitute a Black Swan event—an extremely rare, unpredictable, and highly consequential occurrence that dramatically alters conventional wisdom and scientific consensus. A Black Swan event is defined by its rarity, profound impact, and the tendency for people to rationalize it retrospectively as if it could have been expected. The current scientific consensus, established in the late 1980s and reinforced by overwhelming evidence, is that HIV is the causative agent of AIDS. This consensus is based on decades of research, clinical experience, and the effectiveness of HIV-targeting treatments. If the establishment were to reverse this consensus, it would be unpreceden...
Read more

Perplexity on the issue of endogenous versus exogenous retroviruses. Is this a key to the HIV mistake?

-
  The distinction between endogenous and exogenous retroviruses is often presented as a clear-cut biological fact, but making this determination is not always straightforward—and some arguments support the view that political, institutional, and even social factors play a significant role in where and how the line is drawn. Reasons why this classification can be political and is not always clear-cut: Definition Complexity: Endogenous retroviruses (ERVs) are viral sequences embedded in the germline DNA, inherited across generations, and mainly considered “old,” non-infectious remnants. Exogenous retroviruses are “external” viruses that infect individuals horizontally (from person to person or animal to animal). Yet, both are often nearly indistinguishable at the genetic level—sometimes a retrovirus can exist as both, or transition between the two categories over evolutionary time. Intermediate and Ambiguous Cases: Evidence suggests certain viruses classified as endogenous today were...
Read more

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

-
Image
https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
Read more