We told Perplexity, "Make the case that HHV-8 is the African Swine Fever-like coinfection in AIDS."

-

 From Perplexity A.I.


Make the case that HHV-8 is the African Swine Fever-like coinfection in AIDS.

Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus, is a well-established coinfection in individuals with HIV/AIDS. The comparison to African Swine Fever Virus (ASFV) draws on parallels in pathogenesis, immune evasion, and the profound impact of coinfection on disease outcomes.

Key Parallels Between HHV-8 and African Swine Fever Virus
1. Pathogenic Synergy with Host Immunodeficiency
HHV-8 and AIDS: HHV-8 is a major cause of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD), all of which are significantly more aggressive and prevalent in immunocompromised HIV/AIDS patients.

ASFV in Swine: ASFV causes severe, often fatal hemorrhagic fever in pigs, especially when host immune defenses are compromised. The virus manipulates host immunity to enhance its replication and spread.

2. Coinfection-Driven Disease Progression
HHV-8 as a Cofactor in HIV/AIDS:

HHV-8 coinfection increases HIV replication and reactivation, accelerating disease progression.

Patients with HIV are nearly twice as likely to be seropositive for HHV-8 compared to HIV-negative individuals, and the risk is even higher in certain high-risk groups.

HHV-8 coinfection is associated with increased inflammation and immune activation, even in virologically suppressed HIV patients.

ASFV in Swine:

ASFV exploits immune suppression, leading to rapid and severe disease, often with high mortality rates. Certain ASFV genes (e.g., 8-DR) are directly immunosuppressive, facilitating viral spread and pathogenesis.

3. Immune Evasion and Manipulation
HHV-8: Encodes multiple genes that modulate the host immune response, promoting cell growth and survival, and evading immune detection—mechanisms that are particularly effective in immunosuppressed hosts like those with AIDS.

ASFV: Similarly, ASFV encodes proteins that inhibit host immune responses, delay lymphocyte proliferation, and allow unchecked viral replication.

4. Epidemiological Overlap and Endemicity
HHV-8: Endemic in regions with high HIV prevalence, particularly sub-Saharan Africa, mirroring the distribution of aggressive AIDS-associated KS.

ASFV: Endemic in sub-Saharan Africa, with outbreaks causing devastating losses in swine populations.

Comparative Table: HHV-8 vs. African Swine Fever Virus
Feature HHV-8 in AIDS ASFV in Swine
Host Humans (immunosuppressed) Swine (immunosuppressed or naïve)
Disease KS, PEL, MCD Hemorrhagic fever, high mortality
Coinfection Impact Accelerates HIV progression, KS Exacerbates disease, rapid death
Immune Evasion Multiple viral genes Multiple viral proteins
Epidemiology Endemic in HIV/AIDS regions Endemic in sub-Saharan Africa
Transmission Saliva, sexual, blood, perinatal Ticks, direct contact, pork products
Immunosuppressive Mechanisms Alters cytokines, cell signaling Suppresses lymphocyte proliferation
Conclusion
HHV-8 fulfills the criteria of an "African Swine Fever-like" coinfection in AIDS through its:

Profound synergy with host immunosuppression,

Ability to accelerate disease progression,

Potent immune evasion strategies,

Epidemiological overlap with HIV/AIDS, especially in Africa.

Both viruses demonstrate how coinfection with a potent immunomodulator can dramatically alter disease course, severity, and outcomes in a susceptible host.

References:

 HIV and human herpesvirus 8 co-infection across the globe

 Human Herpesvirus-8 Disease: Adult and Adolescent OIs | NIH

 Human Herpesvirus 8 - an overview | ScienceDirect Topics

 Human herpesvirus 8 enhances human immunodeficiency virus replication in acutely infected cells and induces reactivation in latently infected cells

 Coinfection with Human Herpesvirus 8 Is Associated with Persistent ...

 African swine fever; insights into genomic aspects, reservoirs and ...

 Deletion of a CD2-Like Gene, 8-DR, from African Swine Fever Virus Affects Viral Infection in Domestic Swine

 African swine fever virus - Wikipedia; African Swine Fever - Generalized Conditions

 HHV-8, Kaposi's sarcoma (Herpesviridae) - Free Sketchy Medical ...

Popular Posts in the Last 7 Days

If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? (From Perplexity)

-
 From Perplexity A.I. If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? When reviewing the medical literature on  Chronic Fatigue Syndrome (CFS, also known as Myalgic Encephalomyelitis/ME)  and  AIDS  (Acquired Immunodeficiency Syndrome), several  viruses, infections, and pathological findings  are noted to overlap, though the diseases have distinct etiologies and clinical courses. Viruses and Infections in Common Herpesviruses:  Both conditions are associated with increased prevalence or reactivation of herpesviruses, notably  Cytomegalovirus (CMV)  and  Herpes Simplex Virus (HSV) . In AIDS, CMV is a common opportunistic infection, while in CFS, studies have found higher odd...
Read more

If the nosological definition of AIDS is reset to include all illnesses with serious inflammation regardless of HIV positivity or status, what illnesses could be included in the nosology of AIDS?

-
From Perplexity A.I. If the nosological definition of AIDS is reset to include all illnesses with serious inflammation regardless of HIV positivity or status, what illnesses could be included in the nosology of AIDS? If the nosological definition of AIDS were changed to include all illnesses with serious inflammation regardless of HIV positivity or status, the category would expand dramatically beyond its current, precise meaning. AIDS is currently defined by the presence of HIV infection leading to profound immunodeficiency and a specific set of opportunistic infections and cancers. Chronic inflammation is a hallmark of untreated HIV/AIDS, but it is not unique to it. If “AIDS” were redefined as any illness with serious inflammation, the following types of illnesses could be included: Autoimmune diseases: These are characterized by chronic, often severe inflammation due to the body’s immune system attacking its own tissues. Examples include: Rheumatoid arthritis Systemic lupus erythema...
Read more

More evidence Chronic Fatigue Syndrome is part of the AIDS epidemic?

-
Image
https://www.ncbi.nlm.nih.gov/pubmed/27981498 Mol Neurobiol. 2016 Dec 15. [Epub ahead of print] Humoral Immunity Profiling of Subjects with Myalgic Encephalomyelitis Using a Random Peptide Microarray Differentiates Cases from Controls with High Specificity and Sensitivity. Abstract Myalgic encephalomyelitis (ME) is a complex, heterogeneous illness of unknown etiology. The search for biomarkers that can delineate cases from controls is one of the most active areas of ME research; however, little progress has been made in achieving this goal. In contrast to identifying biomarkers that are directly involved in the pathological process, an immunosignature identifies antibodies raised to proteins expressed during, and potentially involved in, the pathological process. Although these proteins might be unknown, it is possible to detect antibodies that react to these proteins using random peptide arrays. In the present study, we probe a custom 125,000 random 12-mer peptide microarray...
Read more

Consciousness of Guilt in Science and Medicine (From Perplexity A.I.)

-
  Develop the idea that there is something in science and medicine called "consciousness of fraud" (like consciousness of guilt) and list the telltale signs that a scientist is inadvertently showing it. The concept of "consciousness of fraud" in science and medicine parallels legal "consciousness of guilt," reflecting subtle behavioral and linguistic cues that betray a researcher's awareness of misconduct. These involuntary signs manifest through writing patterns, methodological choices, and professional behavior, often revealing attempts to conceal fabricated or manipulated data. Below are key telltale signs, synthesized from empirical studies and expert analyses of scientific fraud: 🔍 Linguistic and Writing Patterns Obfuscation in Language: Fraudulent papers use significantly more jargon, abstract terms, and complex phrasing to obscure methods or results. This "linguistic masking" aims to deter scrutiny, with fraudulent texts containing ~1...
Read more

Popular Post in the Last 30 Days

Consciousness of Guilt in Science and Medicine (From Perplexity A.I.)

-
  Develop the idea that there is something in science and medicine called "consciousness of fraud" (like consciousness of guilt) and list the telltale signs that a scientist is inadvertently showing it. The concept of "consciousness of fraud" in science and medicine parallels legal "consciousness of guilt," reflecting subtle behavioral and linguistic cues that betray a researcher's awareness of misconduct. These involuntary signs manifest through writing patterns, methodological choices, and professional behavior, often revealing attempts to conceal fabricated or manipulated data. Below are key telltale signs, synthesized from empirical studies and expert analyses of scientific fraud: 🔍 Linguistic and Writing Patterns Obfuscation in Language: Fraudulent papers use significantly more jargon, abstract terms, and complex phrasing to obscure methods or results. This "linguistic masking" aims to deter scrutiny, with fraudulent texts containing ~1...
Read more
-
Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
Read more

If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event?

-
 From Perplexity A.I.  If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event? If the scientific establishment were to fundamentally revise the current understanding of AIDS and declare that HIV is not the cause, this would indeed constitute a Black Swan event—an extremely rare, unpredictable, and highly consequential occurrence that dramatically alters conventional wisdom and scientific consensus. A Black Swan event is defined by its rarity, profound impact, and the tendency for people to rationalize it retrospectively as if it could have been expected. The current scientific consensus, established in the late 1980s and reinforced by overwhelming evidence, is that HIV is the causative agent of AIDS. This consensus is based on decades of research, clinical experience, and the effectiveness of HIV-targeting treatments. If the establishment were to reverse this consensus, it would be unpreceden...
Read more

We asked Perplexity A.I. to make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS.

-
 From Perplexity A.I. Make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS. Castleman disease, particularly its HIV-associated multicentric form (HIV-MCD), challenges core paradigms in AIDS medicine across nosology, epidemiology, and virology. Below is a detailed analysis of how this rare lymphoproliferative disorder complicates established frameworks. 🧬 Nosological Challenges HIV-MCD disrupts traditional AIDS classification by: Blurring diagnostic boundaries: It exhibits inflammatory symptoms (e.g., fever, cytopenia) and histopathology (plasmablastic proliferation) that overlap with—but are distinct from—classic AIDS-defining conditions like lymphoma or opportunistic infections. Dual-pathogen dynamics: Diagnosis requires confirming HHV-8 co-infection, positioning it as a viral co-pathogenesis rather than a direct HIV complication. This contrasts with AIDS nosology, which typically centers on HIV as the primary etiological agent. U...
Read more

If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? (From Perplexity)

-
 From Perplexity A.I. If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? When reviewing the medical literature on  Chronic Fatigue Syndrome (CFS, also known as Myalgic Encephalomyelitis/ME)  and  AIDS  (Acquired Immunodeficiency Syndrome), several  viruses, infections, and pathological findings  are noted to overlap, though the diseases have distinct etiologies and clinical courses. Viruses and Infections in Common Herpesviruses:  Both conditions are associated with increased prevalence or reactivation of herpesviruses, notably  Cytomegalovirus (CMV)  and  Herpes Simplex Virus (HSV) . In AIDS, CMV is a common opportunistic infection, while in CFS, studies have found higher odd...
Read more

Popular Posts from the Last Year

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
Read more

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Dr. Rebecca Culshaw Smith's book is discussed on Twitter

-
  #AIDS #HIV #Truvada #TruvadaVictims #ClassAction An eye-opening, heart-breaking investigation. Dr. Rebecca Culshaw Smith's groundbreaking book exposes the tragic reality of 26,000 plaintiffs suing Gilead over the toxic side effects of HIV drug Truvada. https://t.co/PHVoKrafcU pic.twitter.com/hbh3mN4tdI — MyBookLists (@mybooklists) September 12, 2024
Read more

Is African Swine Fever a threat to human health in Congo?

-
Image
https://pmc.ncbi.nlm.nih.gov/articles/PMC7045278/ Our prior reporting on African Swine Fever ASF contaminated meat not entirely safe Besides, ASF-contaminated food could not be entirely safe for humans. “According to the latest research, though the virus is not dangerous to humans, there are documented reactions [of human bodies to ASF] in the form of production of antibodies against it. This indicates an ASF attempt to infect the body and the possibility of a serious weakening of the immune system,” Pavlov said. From 2018 ASF Russia: consumers want liability for sellers of contaminated meat (pigprogress.net) African Swine Fever is a big story already because, when and if it spreads to all of Western Europe and China, it will cause the collapse of a major portion of the agricultural export economies of the affected countries. We're talking about many billions of dollars of losses. And the problem is not temporary because those countries will be suspected of harboring the disease ...
Read more

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
Read more

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

-
Image
https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more