Human herpesvirus 6 (HHV-6) infection and risk of Alzheimer’s disease: a systematic review and meta-analysis

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 This meta-analysis suggests that HHV-6 infection is significantly associated with an increased risk of Alzheimer’s disease. Nevertheless, the exact causal mechanisms remain unclear. Further longitudinal and mechanistic studies are needed to better understand the role of HHV-6 in Alzheimer’s pathogenesis and to evaluate potential antiviral options for preventive or therapeutic strategies.


Popular Posts in the Last 7 Days

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

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  Rebecca Culshaw’s Substack articles establish a foundation for arguing that the mass promotion and use of PrEP (pre-exposure prophylaxis) in HIV prevention could be considered a form of “genocide,” rooted in several lines of critique that challenge both the scientific and ethical underpinnings of the intervention. ​ Critique of Efficacy Claims Culshaw repeatedly questions the reliability of the efficacy data cited for PrEP, especially the widely publicized claim of “99% effectiveness.” She critiques the primary studies behind this figure, particularly the UK “Impact Trial,” highlighting that its actual observed efficacy was only 86%, and that even this figure is derived from retrospective, less scientifically rigorous analysis. She emphasizes that PrEP, to justify the aggressive and potentially coercive marketing campaigns behind it, should meet a much higher bar of evidence given its target population often consists of healthy individuals. By questioning what she perceives as st...
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Perplexity on the nosology and epistemology of AIDS

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 Getting the epistemology and nosology of AIDS correct is more important than conducting further laboratory experiments if the HIV theory is based on fundamentally flawed assumptions. Without a sound conceptual and classificatory framework, all subsequent research becomes prone to perpetuating error, leading to what critics call “zombie science”—scientific activity that persists even when foundational mistakes have invalidated its premises. psychologicalscience ​ Central Role of Epistemology and Nosology Epistemology addresses the foundations of what we claim to know about AIDS—how evidence is interpreted, which assumptions ground the research, and what counts as a disease cause or definition. Nosology is the science of defining and classifying disease. If AIDS is incorrectly conceptualized or the relationship between HIV and AIDS is built on weak, circular, or social assumptions (as some constructionist critics argue), then no amount of experimental activity can correct the traj...
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K.S. and the Jane Teas ASFV hypothesis of AIDS

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  Are spindle cells found in ASFV lesions in pigs? Spindle-shaped cells have been reported in ASFV (African Swine Fever Virus) lesions in pigs, particularly in areas with hemorrhagic lesions such as the epicardium and renal pelvis. These spindle-shaped cells were observed to be labeled with ASFV antigen, indicating that they are infected or affected by the virus. However, the primary cell types infected by ASFV in pigs are macrophages and monocytes, which are more consistently reported as the main targets in the spleen and other organs. While spindle-shaped cells can be found in certain ASFV lesions, they are not considered the main cell type involved in ASFV infection, but rather a morphological feature observed in specific pathological contexts. pmc.ncbi.nlm.nih +2 ​ https://pmc.ncbi.nlm.nih.gov/articles/PMC10927503/ https://journals.asm.org/doi/10.1128/spectrum.02902-24 https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2022.978398/full https://www.na...
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Perplexity A.I. discusses K.S.

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  Make the case that separating HIV and the KS virus epidemic into two parallel or intertwined epidemics actually undermines the whole AIDS paradigm. Separating the HIV and Kaposi's Sarcoma (KS) virus epidemics into two parallel or even just intertwined epidemics actually threatens the conceptual foundation of the AIDS paradigm. The classic AIDS model posits a single, unifying cause—HIV—that triggers a collapse in immune function and thereby “allows” a diverse range of rare infections and cancers, including KS, to emerge. If, instead, KS is attributable to a distinct viral agent (KSHV/HHV-8) acting in parallel with HIV, the paradigm shifts from a single-cause immunodeficiency syndrome to a more complex multi-agent, ecological interplay. AIDS Paradigm: Unified Causation The original AIDS paradigm was built on the conviction that HIV-induced immunosuppression is both necessary and sufficient to account for the spectrum of AIDS-defining illnesses, including opportunistic infections an...
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How to diagnose Chronic Fatigue Syndrome patients for internal Kaposi's Sarcoma

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Diagnosis To determine if a suspicious-looking skin lesion is Kaposi's sarcoma, your doctor will need to perform a biopsy, which involves removing a small piece of tissue for examination in a laboratory. Tests to diagnose internal Kaposi's sarcoma include: Fecal occult blood test. This test detects hidden blood in stool, which can be a sign of Kaposi's sarcoma in the digestive tract. Chest X-ray. A chest X-ray may reveal abnormalities suggesting Kaposi's sarcoma in the lung. Bronchoscopy. In this test, a thin tube (bronchoscope) is passed through your nose or mouth into your lungs to view their lining and take samples of abnormal areas. Upper endoscopy. This test uses a thin tube (endoscope) passed through your mouth to examine the esophagus, stomach and first part of your small intestine. If your doctor suspects Kaposi's sarcoma inside any of these organs, a biopsy of the affected tissue is taken to confirm the disease. Colonoscopy . In this...
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To learn more about HHV-6, AIDS, Chronic Fatigue Syndrome, and the corrupt public health science at the CDC and NIH, read Truth to Power , or Iatrogenocide , or if you really have a sense of humor and like wicked satire, Pig: A Memoir . “Charles Ortleb, as editor-in-chief and publisher of the New York Native , was and remains the Izzy Stone of science reporting.  He was fearless in his pursuit of the origins of the AIDS epidemic and the government’s response in the 1980s.  When his newspaper began to diverge from the dogmatic mainstream, however, he was ostracized by the very people he was seeking to inform.  In addition, his laser-like focus in the Native on the simultaneous emergence of so-called “chronic fatigue syndrome” — a topic to which he assigned a full-time reporter, Neenyah Ostrom—was laudable.  These disorders remain too much alike to arbitrarily submerge one in favor of the other, as the government has done without blinking for thirty yea...
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Popular Post in the Last 30 Days

Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

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  Rebecca Culshaw’s Substack articles establish a foundation for arguing that the mass promotion and use of PrEP (pre-exposure prophylaxis) in HIV prevention could be considered a form of “genocide,” rooted in several lines of critique that challenge both the scientific and ethical underpinnings of the intervention. ​ Critique of Efficacy Claims Culshaw repeatedly questions the reliability of the efficacy data cited for PrEP, especially the widely publicized claim of “99% effectiveness.” She critiques the primary studies behind this figure, particularly the UK “Impact Trial,” highlighting that its actual observed efficacy was only 86%, and that even this figure is derived from retrospective, less scientifically rigorous analysis. She emphasizes that PrEP, to justify the aggressive and potentially coercive marketing campaigns behind it, should meet a much higher bar of evidence given its target population often consists of healthy individuals. By questioning what she perceives as st...
Read more

If one assumeS Rebecca Culshaw's Substack is correct, what were 20 moments in the last 40 ears when scientist should have recognized something was wrong in the HIV/AIDS paradigm?

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From Perplexity A.I.   Assuming Rebecca Culshaw's Substack and books are correct, here are 20 moments in the last 40 years when scientists should have recognized fundamental problems in the HIV/AIDS paradigm, based on major controversies, failed predictions, and repeatedly anomalous findings highlighted by critics like Culshaw and others: Key Moments Highlighting Paradigm Failures 1984: Early claims of HIV as the sole cause of AIDS were made before conclusive evidence, leading to widespread adoption of a viral paradigm without rigorous challenge or alternate hypothesis consideration. ​ Mid-1980s: Discovery disputes between Luc Montagnier (France) and Robert Gallo (US) over the "AIDS virus" involved accusations of sample misappropriation and scientific misconduct, but were glossed over for the sake of an international consensus. ​ 1987: Peter Duesberg publicly challenged the HIV-AIDS causation model, noting unanswered questions around risk group disease patterns and viral ...
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New cartoon

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From a forthcoming Julian Lake collection of cartoons about P-hacking in AIDS and Chronic Fatigue Syndrome research. Don't know what P-hacking is? Read this article in the New York Times . Julian Lake most recent collection of cartoons about Chronic Fatigue Syndrome and AIDS is here . See more of Julian Lake's P-hacking cartoon at P-hack University . To learn more about the P-hacking culture of AIDS, Chronic Fatigue Syndrome, and public health science at the CDC and NIH, read Truth to Power , or Iatrogenocide , or if you really have a sense of humor and like wicked satire, Pig: A Memoir .
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Perplexity on Rebecca Culshaw Smith and Fauci's original thinking about AIDS

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  Rebecca Culshaw Smith and Fauci's original thinking about AIDS If Rebecca Culshaw Smith succeeds in debunking David Ho’s foundational AIDS research, it would fundamentally challenge the modern scientific consensus that HIV is the primary and necessary cause of AIDS. This would retroactively cast early uncertainties and warnings—including Anthony Fauci’s 1983 statements suggesting that household contact could transmit AIDS—in a new light. Fauci’s initial warnings were rapidly criticized and later walked back when HIV was identified as the key driver of transmission and the modes of contagion were clarified by subsequent research led by figures like David Ho. ​ Fauci’s Early Warnings In the early years of the epidemic, Fauci and other researchers speculated that the clustering of pediatric AIDS cases in households suggested possible routine contact transmission, not just sexual, bloodborne, or perinatal routes. Fauci’s public statements reflected real concern about the ambiguous da...
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Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV

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  Activation of endogenous retrovirus reverse transcriptase in multiple sclerosis patient lymphocytes by inactivated HSV-1, HHV-6 and VZV - Aarhus University Abstract Human endogenous retroviruses (HERVs) and herpesviruses have been associated with the development of multiple sclerosis (MS). These virus groups interact with each other and have been shown to induce synergistic immune responses. Here, we focus on the possible role of herpesviruses as contributing factors in HERV activation. We demonstrate the ability of HSV-1, HHV-6, and VZV antigens to induce higher RT activity in peripheral lymphocytes from MS patients vs. controls during the first 6 days post-antigen stimulation. On subsequent days, only VZV can sustain the increase in the RT expression in cells from MS patients. The RT induction does not depend on herpes replication.
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Perplexity A.I. on the potential impact of Rebecca Culshaw Smith

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  Perplexity A.I. on the potential impact of Rebecca Culshaw Smith: Rebecca Culshaw's debunking of David Ho's foundational AIDS research and the HIV/AIDS paradigm claims that the connection between HIV and AIDS is unsupported by critical scientific evidence, citing flaws in research, data interpretation, and the toxicity of AIDS drugs. If her critique is accepted and validated by the scientific community, it could expose fundamental misconceptions about immune system dysfunction and open new avenues for understanding mysterious inflammatory immunological diseases. ​ Potential Impact on Immunological Diseases Culshaw argues that the AIDS paradigm’s misdiagnosis and mistreatment with toxic drugs perpetuates chronic inflammation and immune imbalance, possibly paralleling other unexplained immunological diseases like chronic fatigue, autoimmunity, and inflammatory syndromes. ​ By questioning the virological basis of AIDS, alternative hypotheses anchor disease causation in pharmacol...
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Perplexity on the irony of debunking David Ho's HIV research

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  The irony lies in the fact that David Ho’s foundational AIDS research not only shaped the dominant scientific paradigm for understanding and treating HIV/AIDS, but also established the nosology—the classification and definition of the disease itself—upon which all subsequent research and clinical practice was built. If his core research were to be debunked, it would not only undermine the prevailing scientific consensus about HIV/AIDS, but also destabilize the very framework that defines what AIDS is, how it is diagnosed, and how it is categorized in medical literature. ​ The Paradigm and Nosology Connection David Ho’s work, especially his demonstration that combination antiretroviral therapy could suppress HIV to undetectable levels, became a cornerstone of the AIDS research paradigm. This paradigm includes the understanding of HIV as a chronic, treatable disease and the classification of AIDS based on specific clinical and immunological criteria. The nosology of AIDS—its diagno...
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Popular Posts from the Last Year

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Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
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Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

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"HHV-6 is actually likely to reduce HIV patient survival by accelerating the depletion of CD4 and CD8 T cells. HHV-6A was shown to accelerate AIDS progression in macaques.  Macaques co-infected with simian HIV and HHV-6A died quickly and showed a dramatic depletion in both CD4+ and CD8+ T cells, whereas those infected with only simian HIV never progressed to full blown AIDS."  "We believe that infections are the most logical explanation for the inflammation neurodegeneration associated with Alzheimer’s , but don’t believe that there is a single pathogen responsible. HHV-6A and HHV-7 were identified as likely culprits in 2018 paper , using RNAseq analysis by Readhead and team. Two subsequent studies did not find an increase in HHV-6/7 using the same data, but at the same time did not find a significant presence of ANY herpesviruses in the brain, which we know is not the case. Dozens of careful studies have identified a high prevalence of low-level HHV-6 and HSV1 DN...
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Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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Why HIV should be referred to as "a red herring."

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 From Perplexity A.I. Make the case that the critics of the HIV theory of AIDS would be more effective at their messaging to politicians and the public by constantly referring to HIV as a red herring. Critics of the HIV theory of AIDS—those who argue that HIV is not the causative agent of AIDS—often struggle to convey their message effectively to politicians and the public because the scientific consensus firmly upholds the link between HIV and AIDS. However, from a communications strategy perspective, such critics might amplify the clarity and urgency of their argument by consistently describing HIV as a "red herring." Here’s why this tactic could make their messaging more effective: 1. Framing the Narrative Labeling HIV as a "red herring" frames the dominant scientific focus on the virus as a distraction from finding the true cause of AIDS (as the critics would argue). This concise phrase presents the debate in terms of misdirection, which is an accessible and com...
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Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

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Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
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Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

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How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
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Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

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https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
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