HHV-6 University

http://www.cortjohnson.org/blog/2014/01/09/lipkin-study-vagus-nerve-hhv-6-loomis-hhv-6-foundation/  

http://www.nature.com/jidsp/journal/v6/n3/full/5640056a.html

http://www.ncbi.nlm.nih.gov/pubmed/24282390 Abstract Human herpesvirus 6 (HHV-6) infection is common and has a worldwide distribution. Recently, HHV-6A and HHV-6B have been reclassified into two distinct species based on different biological features (genetic, antigenic, and cell tropism) and disease associations. A role for HHV-6A/B has been proposed in several autoimmune disorders (AD), including multiple sclerosis (MS), autoimmune connective tissue diseases, and Hashimoto's thyroiditis. The focus of this review is to discuss the above-mentioned AD associated with HHV-6 and the mechanisms proposed for HHV-6A/B-induced autoimmunity. HHV-6A/B could trigger autoimmunity by exposing high amounts of normally sequestered cell antigens, through lysis of infected cells. Another potential trigger is represented by molecular mimicry, with the synthesis of viral proteins that resemble cellular molecules, as a mechanism of immune escape. The virus could also induce aberra...

http://www.hindawi.com/journals/isrn.virology/2013/834890/ Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study. CONCLUSION: Neuroinflammation is present in widespread brain areas in CFS/ME patients and was associated with the severity of neuropsychologic symptoms.  http://www.ncbi.nlm.nih.gov/pubmed/24665088

http://www.ncbi.nlm.nih.gov/pubmed/24555113

http://www.ncbi.nlm.nih.gov/pubmed/24611562 Abstract Chemotherapy improves the outcome of cancer treatment, but patients are sometimes forced to discontinue chemotherapy or drop out of a clinical trial due to adverse effects, such as gastrointestinal disturbances and suppression of bone marrow function. The objective of this study was to evaluate the safety and effectiveness of a mushroom product, active hexose correlated compound (AHCC), on chemotherapy-induced adverse effects and quality of life (QOL) in patients with cancer. Twenty-four patients with cancer received their first cycle of chemotherapy without AHCC and then received their second cycle with AHCC. During chemotherapy, we weekly evaluated adverse effects and QOL via a blood test, EORTC QLQ-C30 questionnaire, and DNA levels of herpes virus type 6 (HHV-6) in saliva. The DNA levels of HHV-6 were significantly increased after chemotherapy. Interestingly, administration of AHCC significantly decreased the l...

http://www.ncbi.nlm.nih.gov/pubmed/?term=sedlak+ddpcr

http://www.ncbi.nlm.nih.gov/pubmed/24663487 Abstract The human herpesviruses HHV-6A and HHV-6B have been associated with various neurologic disorders partly due to the detection of elevated viral DNA levels in patients compared to controls. However the reported frequency of these viruses varies widely, likely reflecting differences in PCR methodologies used for detection. Digital droplet PCR (ddPCR) is a third generation PCR technology that enables the absolute quantification of target DNA molecules. Mounting evidence of the biological differences between HHV-6A and HHV-6B has led to their recent reclassification as separate species. As it is now especially relevant to investigate each virus, our objectives were to first design a multiplex HHV-6A and HHV-6B ddPCR assay and then to investigate the incidence of HHV-6A and HHV-6B coinfection in samples from healthy donors and patients with MS, a disease in which HHV-6 is thought to play a role. In our assessment of hea...

http://www.jneurosci.org/content/24/20/4875/suppl/DC 1

http://www.dailymail.co.uk/health/article-386443/Is-cure-ME.html

http://www.ncf-net.org/library/hillary.htm

http://onlinelibrary.wiley.com/doi/10.1111/j.1348-0421.2007.tb03996.x/pdf

http://hhv-6foundation.org/news/humanized-mouse-model-demonstrates-hhv-6a-infection-can-cause-significant-immune-dysfunction

 http://www.ncbi.nlm.nih.gov/pubmed/24006442 J Virol. 2013 Nov;87(22):12020-8. doi: 10.1128/JVI.01556-13. Epub 2013 Sep 4. Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2-/-γc-/- Mice. Tanner A , Carlson SA , Nukui M , Murphy EA , Berges BK . Source Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah, USA. Abstract Although serious human diseases have been correlated with human herpesvirus 6A (HHV-6A) and HHV-6B, the lack of animal models has prevented studies which would more definitively link these viral infections to disease. HHV-6A and HHV-6B have recently been classified as two distinct viruses, and in this study we focused specifically on developing an in vivo model for HHV-6A. Here we show that Rag2(-/-)γc(-/-) mice humanized with cord blood-derived human hematopoietic stem cells produce human T cells that express the major HHV-6A receptor, CD46. Both cell-associated and cell-free viral ...

http://archinte.jamanetwork.com/article.aspx?articleid=617124&resultClick=1

http://www.hindawi.com/journals/tswj/2013/867389/

http://www.bioportfolio.com/search/T-cell-recall-and-cross-reactivity.html

http://www.hindawi.com/journals/tswj/aip/867389/

http://www.healthtechnologynet.com/articles/viewarticle.jsp?id=2796030&type=home

http://www.ncbi.nlm.nih.gov/pubmed/19501020

http://hhv-6foundation.org/conditions-associated-with-hhv-6

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"HHV-6–positive cells and CMV-positive cells were frequently found in the gastroduodenal mucosa of liver transplant recipients and of immunocompetent patients undergoing gastroscopic examination because of dyspeptic symptoms." Leena Halme, Johanna Arola, Krister Höckerstedt, and Irmeli Lautenschlager http://cid.oxfordjournals.org/content/46/3/434.full

odel David J. Mock et. al. Abstract Background Human Herpesvirus 6 was previously demonstrated to infect human oligodendroglial precursor cells (OPCs) in vitro causing cell cycle arrest and premature differentiation with consequent loss of the precursor pool. Objectives To develop an in vitro murine OPC model to study the cell cycle and differentiation effects of HHV-6 in more readily available, genetically well-defined cells free of the risk of contamination with human herpesviruses. Study design Murine OPCs were exposed to infectious HHV-6A or HHV-6B and analyzed for production of viral transcripts, particles, and replicating virus. FACS analysis and specific markers were used to evaluate effects on cell cycling and differentiation. Results HHV-6 infection of murine OPCs resulted in production of both immediate-early and some late transcripts but no replicating virus by TaqMan quantitative PCR or electron microscopy. Both a specific G1/S cell cycle a...

http://topnews.us/content/242425-hhv-6-virus-may-enter-brain-nose-say-experts

Multisystemic HHV-6 and Antiphospholipid Syndrome Autoantibodies in Autism Are Autism Spectrum Disorders part of the Multisystemic HHV-6 Spectrum of Disorders? Is the Multisystemic HHV-6 Epidemic Causing the Dramatic Rise in Autism? Can the complications of Autism Spectrum Disorder be reduced by controlling Multisystemic HHV-6? Why won't the Centers for Disease Control tell the truth about the role of Multisystemic HHV-6 in Autism, Chronic Fatigue Syndrome, AIDS and many other serious neuroimmunological syndromes? What exactly is Multisystemic HHV-6? Is it really just a reactivated herpes virus or is it actually some other kind of lethal virus that can be passed from person to person and can become chromsomally integrated? Does it belong in a class by itself? Where did it come from? Is it a zoonose, a virus that is circulating in people and animals? "About six weeks back I was given the name of a woman who had approached Generation Rescue. She has a foun...

http://www.ncbi.nlm.nih.gov/pubmed/23419479

HHV-6 in Alzheimer's disease: relation to progression of the disease  http://www.ncbi.nlm.nih.gov/pubmed/23916950