Changes in cerebrospinal fluid biomarkers in human herpesvirus-6-associated acute encephalopathy/febrile seizures.

-

Abstract

To determine the involvement of oxidative stress in the pathogenesis of acute encephalopathy associated with human herpesvirus-6 (HHV-6) infection, we measured the levels of oxidative stress markers 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL), tau protein, and cytokines in cerebrospinal fluid (CSF) obtained from patients with HHV-6-associated acute encephalopathy (HHV-6 encephalopathy) (n = 16) and complex febrile seizures associated with HHV-6 (HHV-6 complex FS) (n = 10). We also examined changes in CSF-8OHdG and CSF-HEL levels in patients with HHV-6 encephalopathy before and after treatment with edaravone, a free radical scavenger. CSF-8-OHdG levels in HHV-6 encephalopathy and HHV-6 complex FS were significantly higher than in control subjects. In contrast, CSF-HEL levels showed no significant difference between groups. The levels of total tau protein in HHV-6 encephalopathy were significantly higher than in control subjects. In six patients with HHV-6 infection (5 encephalopathy and 1 febrile seizure), the CSF-8-OHdG levels of five patients decreased after edaravone treatment. Our results suggest that oxidative DNA damage is involved in acute encephalopathy associated with HHV-6 infection.

http://www.ncbi.nlm.nih.gov/pubmed/25294958

Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury.

Abstract
Recanalization and neuroprotection have been mainly targeted for the specific treatment of acute ischemic stroke. Free radicals play a crucial role in brain ischemic injury by exacerbating membrane damage through peroxidation of unsaturated fatty acids of cell membrane, leading to neuronal death and brain edema. Free radicals have been implicated in stroke pathophysiology as pivotal contributors to cell injury. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a novel potent free radical scavenger that has been clinically used to reduce the neuronal damage following ischemic stroke. Edaravone exerts neuroprotective effects by inhibiting endothelial injury and by ameliorating neuronal damage in brain ischemia. Edaravone provides the desirable features of NOS: it increases eNOS (beneficial NOS for rescuing ischemic stroke) and decreases nNOS and iNOS (detrimental NOS). Post- reperfusion brain edema and hemorrhagic events induced by thrombolytic therapy may be reduced by edaravone pretreatment. Increased productions of superoxide and NO in the brain after reperfusion and a concomitant surge in oxygen free radicals with increased NO during recirculation lead to formation of peroxynitrite, a superpotent radical. Edaravone, which inhibits oxidation and enhances NO production derived from increased eNOS expression, may improve and conserve cerebral blood flow without peroxynitrite generation during reperfusion. Clinical experience with edaravone suggests that this drug has a wide therapeutic time window. The combination therapy (a thrombolytic plus edaravone) is likely to target brain edema, reduce stroke death and improve the recovery from neurological deficits in stoke patients.
http://www.ncbi.nlm.nih.gov/pubmed/16834755

Wikipedia on Edaravone
 http://en.wikipedia.org/wiki/Edaravone
Edaravone (Radicut) is a neuroprotective agent used for the purpose of aiding neurological recovery following acute brain ischemia and subsequent cerebral infarction.[1] It acts as a potent antioxidant and strongly scavenges free radicals, protecting against oxidative stress and neuronal apoptosis.[2][3][4] It has been marketed solely in Japan by Mitsubishi Pharma since 2001.[1] and marketed in India by Edinburgh Pharmaceuticals by the brand name Arone
Edaravone has been shown to attenuate methamphetamine- and 6-OHDA-induced dopaminergic neurotoxicity in the striatum and substantia nigra, and does not affect methamphetamine-induced dopamine release or hyperthermia.[5][6] It has also been demonstrated to protect against MPTP-mediated dopaminergic neurotoxicity to the substantia nigra, though notably not to the striatum.[7][8][9]

Popular Posts in the Last 7 Days

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                                            In The Chronic Fatigue Syndrome Epidemic Cover-up, C
Read more
-
Image
Want to know more about Chronic Fatigue Syndrome? Read The Chronic Fatigue Syndrome Epidemic Cover-up . If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  \ This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue Syndrome" is a mystery for over three decades? By the end of this book of inconvenient truths the answer is crystal clear. The shocking news and bold analysis in this page-turner could lead to a revolution in the science and politics of
Read more

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR
Read more

The Chronic Fatigue Syndrome and HHV-6 Scientist of the Year

-
Image
Follow @HHV6_University Tweet The scientist who deserves a Nobel Prize for his work on HHV-6 and Chronic Fatigue Syndrome. https://www.uni-wuerzburg.de/en/news-and-events/news/detail/news/viruses-under-the-microscope/ Viruses Under the Microscope 09/14/2018 Human herpesviruses such as HHV-6 can remain dormant in cells for many years without being noticed. When reactivated, they can cause serious clinical conditions. Researchers from Würzburg have now found a way of differentiating between active and inactive viruses.  Human herpesvirus 6 (HHV-6) infects almost all of the human population, but only very few will show any symptoms during their lifetime: HHV-6 is one of the most widespread viruses among the population. Between 95 and 100 percent of healthy adults have antibodies to the virus which means that they have been infected at some point in the past. The virus hides in the g
Read more

More evidence HHV-6 is the cause of Chronic Fatigue Syndrome.

-
HHV-6 encephalopathy associated with structural changes in the olfactory pathway https://hhv-6foundation.org/encephalitis-encephalopathy/hhv-6-encephalopathy-and-ultrastructural-changes-in-the-olfactory-pathway Want to know more about the relationship between HHV-6 and Chronic Fatigue Syndrome? Read The Chronic Fatigue Syndrome Epidemic Cover-up . If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue
Read more

If you want to know the whole truth about Chronic Fatigue Syndrome, you need to go Beyond Unrest

-
Image
HHV-6 is discussed in this Chronic Fatigue Syndrome Amazon bestseller on pages 98, 100, 122, 133-135, 143-147, 150, 153, 159, 163, 166, 179, 183, 192, 193, 198, 199, 200, 202, 204, 205, and 211. Ampligen, the breakthrough treatment for Chronic Fatigue Syndrome is discussed in the Amazon bestseller on pages 192, 193, 202, 203, 268, 269, 360, 362, 387, 391, 410, 413, 420, and 421. Anthony Fauci, the architect of the CFS cover-up, is discussed in this Amazon bestseller on pages 71, 103, 104, 26, 130-133, 139, 143, 157, 161, 169-171, 173, 174, 221, 254, 289, 292, 293, 300, 320-322, 324, 335, 356-358, 361, 367, and 398. Dr. Paul Cheney, one of the honest pioneers of Chronic Fatigue Syndrome research is discussed in the Amazon bestseller on pages 145, 146, 155, 166, 192, 219, 225, 226, 232, 242, 244, 326, 327, 352, 402, 434, and 435. Konnie Knox's pioneering research into HHV-6 is discussed in this book on page 428-431. Hillary Johnson's brilliant reporting o
Read more

Popular Post in the Last 30 Days

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                                            In The Chronic Fatigue Syndrome Epidemic Cover-up, C
Read more
-
Image
Want to know more about Chronic Fatigue Syndrome? Read The Chronic Fatigue Syndrome Epidemic Cover-up . If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  \ This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue Syndrome" is a mystery for over three decades? By the end of this book of inconvenient truths the answer is crystal clear. The shocking news and bold analysis in this page-turner could lead to a revolution in the science and politics of
Read more

If you want to know the whole truth about Chronic Fatigue Syndrome, you need to go Beyond Unrest

-
Image
HHV-6 is discussed in this Chronic Fatigue Syndrome Amazon bestseller on pages 98, 100, 122, 133-135, 143-147, 150, 153, 159, 163, 166, 179, 183, 192, 193, 198, 199, 200, 202, 204, 205, and 211. Ampligen, the breakthrough treatment for Chronic Fatigue Syndrome is discussed in the Amazon bestseller on pages 192, 193, 202, 203, 268, 269, 360, 362, 387, 391, 410, 413, 420, and 421. Anthony Fauci, the architect of the CFS cover-up, is discussed in this Amazon bestseller on pages 71, 103, 104, 26, 130-133, 139, 143, 157, 161, 169-171, 173, 174, 221, 254, 289, 292, 293, 300, 320-322, 324, 335, 356-358, 361, 367, and 398. Dr. Paul Cheney, one of the honest pioneers of Chronic Fatigue Syndrome research is discussed in the Amazon bestseller on pages 145, 146, 155, 166, 192, 219, 225, 226, 232, 242, 244, 326, 327, 352, 402, 434, and 435. Konnie Knox's pioneering research into HHV-6 is discussed in this book on page 428-431. Hillary Johnson's brilliant reporting o
Read more

More evidence HHV-6 is the cause of Chronic Fatigue Syndrome.

-
HHV-6 encephalopathy associated with structural changes in the olfactory pathway https://hhv-6foundation.org/encephalitis-encephalopathy/hhv-6-encephalopathy-and-ultrastructural-changes-in-the-olfactory-pathway Want to know more about the relationship between HHV-6 and Chronic Fatigue Syndrome? Read The Chronic Fatigue Syndrome Epidemic Cover-up . If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue
Read more

Popular Posts from the Last Year

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                                            In The Chronic Fatigue Syndrome Epidemic Cover-up, C
Read more

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR
Read more
-
Image
Want to know more about Chronic Fatigue Syndrome? Read The Chronic Fatigue Syndrome Epidemic Cover-up . If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  \ This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue Syndrome" is a mystery for over three decades? By the end of this book of inconvenient truths the answer is crystal clear. The shocking news and bold analysis in this page-turner could lead to a revolution in the science and politics of
Read more

If you want to know the whole truth about Chronic Fatigue Syndrome, you need to go Beyond Unrest

-
Image
HHV-6 is discussed in this Chronic Fatigue Syndrome Amazon bestseller on pages 98, 100, 122, 133-135, 143-147, 150, 153, 159, 163, 166, 179, 183, 192, 193, 198, 199, 200, 202, 204, 205, and 211. Ampligen, the breakthrough treatment for Chronic Fatigue Syndrome is discussed in the Amazon bestseller on pages 192, 193, 202, 203, 268, 269, 360, 362, 387, 391, 410, 413, 420, and 421. Anthony Fauci, the architect of the CFS cover-up, is discussed in this Amazon bestseller on pages 71, 103, 104, 26, 130-133, 139, 143, 157, 161, 169-171, 173, 174, 221, 254, 289, 292, 293, 300, 320-322, 324, 335, 356-358, 361, 367, and 398. Dr. Paul Cheney, one of the honest pioneers of Chronic Fatigue Syndrome research is discussed in the Amazon bestseller on pages 145, 146, 155, 166, 192, 219, 225, 226, 232, 242, 244, 326, 327, 352, 402, 434, and 435. Konnie Knox's pioneering research into HHV-6 is discussed in this book on page 428-431. Hillary Johnson's brilliant reporting o
Read more

More evidence HHV-6 is the cause of Chronic Fatigue Syndrome.

-
HHV-6 encephalopathy associated with structural changes in the olfactory pathway https://hhv-6foundation.org/encephalitis-encephalopathy/hhv-6-encephalopathy-and-ultrastructural-changes-in-the-olfactory-pathway Want to know more about the relationship between HHV-6 and Chronic Fatigue Syndrome? Read The Chronic Fatigue Syndrome Epidemic Cover-up . If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue
Read more

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                                            In The Chronic Fatigue Syndrome Epidemic Cover-up, C
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                                                In his bestselling book, The Black Swan , Nassim Nich
Read more

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

-
Image
https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Congress can mandate research into CFS as a contagious, viral disease. I will certainly try to get Congress to do that as
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more