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Monday, October 23, 2017

Pigs and Chronic Fatigue Syndrome

The porcine lymphotropic herpesvirus 1 encodes functional regulators of gene expression

"Recently, new porcine lymphotropic gammaherpesviruses (PLHV-1, -2 and -3) have been identified, which are highly prevalent in domestic and feral pigs. The genomes of these viruses are homologous to those of the human gammaherpesviruses Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8), which are frequently associated with important diseases in transplant recipients (Ehlers et al., 1999; Ulrich et al., 1999; Goltz et al., 2002; Chmielewicz et al., 2003). EBV is associated with post-transplantation lymphoproliferative disorders (PTLD), affecting approximately 1–10% of solid organ transplant recipients (reviewed by Razonable and Paya, 2003). HHV-8 is tightly linked to Kaposi's Sarcoma (KS), which occurs in up to 5% of patients receiving a transplant (reviewed by Singh, 2000). Importantly, PLHV-1 was found to be involved in the etiology of a lymphoproliferative disease, affecting experimentally transplanted and immunosuppressed miniature swine. This porcine disease resembled the EBV-associated PTLD in humans (Huang et al., 2001)."

Why are CFS patients infected with an AIDS-associated Kaposi's sarcoma virus? Did it come from pigs?

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