Will Bhupesh Prusty add more evidence that HHV-6 is the cause of Chronic Fatigue Syndrome?

Tweet

https://solvecfs.org/hhv-6-mediated-mitochondrial-modulation-and-its-possible-association-to-mecfs/

HHV-6 Mediated Mitochondrial Modulation and Its Association to ME/CFS

A project summary as written by Bhupesh Prusty:

Infections are frequently associated with chronic disease development and likely, play crucial roles in the onset or progression of several human disorders that are not classified as infectious diseases.Myalgic encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) is one such example. However, the precise role of pathogens in ME/CFS development remains, predominantly, uncharacterized. Human Herpesvirus 6 (HHV-6) is frequently associated with several human diseases including ME/CFS. Work from my laboratory as well as from others have shown that HHV-6 frequently integrates into human chromosomes in order to achieve latency (ciHHV-6). Originally, ciHHV-6 was thought to be the dead end for the virus. However recent publications demonstrate that certain timely triggers like circumstances of immune suppression or influence of various drugs and/or pathogenic infections can activate the integrated virus.

Our preliminary work shows that HHV-6 targets the cell’s energy reserve, the mitochondria, during

both active infection and activation from latency leading to mitochondrial dysfunction, a condition thatis also frequently associated with ME/CFS. Using a unique latent and chromosomally integrated

HHV-6 cell culture model, we have observed down regulation of a small non-coding human microRNA

in response to viral infection that induces expression of tumor suppressor protein p53 and

subsequently that of Drp1 leading to mitochondrial fragmentation. Because of these events,

mitochondria from the infected cells tend to have lower ATP generation capacity and reduced

efficiency for maintaining calcium homeostasis. In this proposal, we aim to dissect out the contributing  factor from HHV-6 that is directly responsible for the signaling processes leading to host cell

mitochondrial alteration. We have identified several viral miRNAs that are specifically expressed

during both active infection and viral activation. We hypothesize that these viral miRNAs play a key

role in alteration of mitochondrial fission-fusion dynamics. Our final aim is to link HHV-6 and

mitochondrial alterations using ME/CFS patient materials. Molecular mechanisms behind direct

association between HHV-6 and human mitochondria have never been studied before. The proposed

project aims to elucidate the molecular mechanism(s) by which HHV-6 infection actuates mitochondrial

dysfunction in ME/CFS patients, likely, resulting in the development/progression of ME/CFS.

The anticipated outcome of this pioneering research idea is the elucidation of a novel infection induced

mechanism for the onset and/or progression of ME/CFS. Understanding etiology of

mitochondrial modulation from thus far unknown causative agents will open new targets for drug

development. Infectious agents behind mitochondrial modulation in ME/CFS are poorly characterized

and the proposed research aims to address this unexplored avenue. The idea that a common virus

like HHV-6 could associate with host cell mitochondria and modulate its function (and contribute to

disease) has not been hypothesized before. I believe that my project has tremendous potential to

revolutionize the preconceived theories about pathogenic causes behind ME/CFS and is in line with

the Solve ME/CFS Initiative’s mission as well as funding objectives.

Want to learn more about HHV-6, which is causing the endogenous retrovirus problem in AIDS and Chronic Fatigue Syndrome?

If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book about the history of HHV-6.

If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades.

Click here to begin reading

Or purchase a print copy for only $20 shipped by Amazon Prime 

This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.

                                                              

In his bestselling book, The Black Swan, Nassim Nicholas Taleb wrote, "I see the risks of a very strange acute virus spreading throughout the planet." This book by Charles Ortleb warns that the virus causing Chronic Fatigue Syndrome is that virus.

This book belongs in the library of anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic and the deadly virus HHV-6. Why have the CDC and NIH pretended that the communicable disease fraudulently called "Chronic Fatigue Syndrome" is a mystery for over three decades? By the end of this book of inconvenient truths the answer is crystal clear. The shocking news and bold analysis in this page-turner could lead to a revolution in the science and politics of Chronic Fatigue Syndrome, fibromyalgia, AIDS, autism, and many other illnesses. Scientists, doctors, nurses, patients, journalists, politicians, and historians must begin their journey to a full understanding of the Chronic Fatigue Syndrome epidemic with this book.

As the publisher and editor-in-chief of a small newspaper in New York, Charles Ortleb was the first journalist to devote a publication to uncovering the truth about Chronic Fatigue Syndrome. He assigned Neenyah Ostrom the duty of following every twist and turn of the Chronic Fatigue Syndrome story. No newspaper in the world did more to warn the world about the virus which seems to be triggering Chronic Fatigue Syndrome and many other immunological disorders. Chronic Fatigue Syndrome and AIDS are just the tip of the HHV-6 iceberg.

This provocative book will end the injustice of the silent treatment Neenyah Ostrom's reporting has been getting from the media and The Chronic Fatigue Syndrome community. Ostrom blew the lid off one of the biggest medical secrets of our time: the link between the Chronic Fatigue Syndrome epidemic and AIDS.

Ostrom interviewed most of the major researchers in the field, as well as countless patients and government scientists. She uncovered so many similarities between Chronic Fatigue Syndrome and AIDS that she came to the conclusion that they are part of the same epidemic, and she argued that until their connection is admitted by top government researchers, there is little hope of making real progress in the fight against Chronic Fatigue Syndrome.

Charles Ortleb's book captures all the challenges and excitement of running a small newspaper that was publishing a brilliant journalist who essentially was the Woodward and Bernstein of the Chronic Fatigue Syndrome epidemic. In Rolling Stone, David Black said Ortleb's newspaper deserved a Pulitzer Prize. Randy Shilts praised Ortleb's newspaper in And the Band Played On.

                                                            

This book continues the work Ortleb has been doing to raise awareness about HHV-6 and Chronic Fatigue Syndrome at his website HHV-6 University. Fewer and fewer people now pretend that HHV-6 is harmless. Thanks to Ortleb's efforts, more and more people are abandoning HHV-6 denialism and admitting the virus is at the center of a public health disaster.

 Hillary Johnson, the author of Osler's Web, called it "A rollicking, fascinating and important memoir."

Purchase the book in Canada 

Purchase the book in Mexico

Purchase the book in the United Kingdom

Purchase the book in Germany

Purchase the book in France

Purchase the book in the Netherlands

Purchase the book in Spain

Purchase the book in Australia

Purchase the book in Japan

Purchase the book in India

The HHV-6 University Report by rubiconmedia on Scribd