Human herpesvirus 6 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus.

-


Human herpesvirus 6 activates lytic cycle 

The American Journal of Pathology [01 Jan 2005, 166(1):173-183]

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is a gamma-herpesvirus consistently identified in Kaposi's sarcoma (KS), primary effusion lymphoma, and multicentric Castleman's disease. KSHV infection appears to be necessary, but not be sufficient for development of KS without other co-factors. However, factors that facilitate KSHV to cause KS have not been well defined. Because patients with KS are often immunosuppressed and susceptible to many infectious agents including human herpesvirus 6 (HHV-6), we investigated the potential of HHV-6 to influence the replication of KSHV. By co-culturing HHV-6-infected T cells with KSHV-latent BCBL-1 cell line, infecting BCBL-1 cells with HHV-6 virions, and generating heterokaryons between HHV-6-infected T cells and BCBL-1 cells, we showed that HHV-6 played a critical role in induction of KSHV replication, as determined by production of lytic phase mRNA transcripts and viral proteins. We confirmed and extended the results by using a luciferase reporter assay in which KSHV ORF50 promoter, the first promoter activated during KSHV replication, drove the luciferase expression. Besides HHV-6, we also found that cytokines such as interferon-gamma partially contributed to induction of KSHV replication in the co-culture system. These findings suggest that HHV-6 may participate in KS pathogenesis by promoting KSHV replication and increasing KSHV viral load.




https://europepmc.org/abstract/pmc/pmc1602294

Popular Posts in the Last 7 Days

Is Kaposi's Sarcoma in Uganda connected to the African Swine Fever epidemic in pigs?

-
  Factors affecting Kaposi's sarcoma-associated herpesvirus transmission in rural Ugandan households, a longitudinal study - PubMed (nih.gov) From Groq According to the study, the ASF virus was detected in pigs in several districts in Uganda, including rural areas. The study suggests that the virus may have been introduced to the country through infected wild boars or contaminated feed. The study's findings highlight the importance of surveillance and control measures to prevent the spread of ASF in Uganda and other countries. Thank you for sharing this article, which provides valuable information on the presence of ASF in Uganda. I will make sure to update my knowledge and provide more accurate information in the future. Frontiers | Prevention and Control of African Swine Fever in the Smallholder Pig Value Chain in Northern Uganda: Thematic Analysis of Stakeholders' Perceptions (frontiersin.org)
Read more

Will Fauci screw up Zika as much as he has screwed up HHV-6, AIDS and Chronic Fatigue Syndrome?

-
     November 2, 1984 was an especially tragic day in the Chronic Fatigue Syndrome/AIDS epidemic. That was the day Anthony Fauci became the Director of the National Institutes of Allergy and Infectious Diseases. (NIAID). ( Good Intentions p.128) It was the day a thin-skinned, physically ultra-diminutive man with a legendary Napoleonic attitude was positioned by destiny to become the de facto AIDS Czar. In the fog of culpability that constitutes what could be called "Holocaust II" one thing is clear: the HIV/AIDS buck, on its way to the very top of the government, at least pauses at the megalomaniac desk of Anthony Fauci.      In his book, Good Intentions , Bruce Nussbaum writes, “Fauci looked as if he had just stepped out of a limousine. Trim and athletic, Fauci’s tailored suits, cuff-linked shirts, and aviator glasses set him far apart from the rest of the scientists and administrators at the NIH.” ( GI p.128) Fauci had risen quickly...
Read more

Celia Farber's groundbreaking reporting on AIDS will be published in March

-
Image
Serious Adverse Events: An Uncensored History of AIDS: Farber, Celia, Miller, Mark Crispin: 9781645022077: Amazon.com: Books   “Farber [is] a lucid and courageous witness to the power-play behind the first ‘scamdemic,’ . . . [Her] work is journalism at its best―solid, lucid, and humane, attacking wrongs that few dare touch, and thereby helping right them.” ―Mark Crispin Miller, bestselling author and professor of media studies at NYU On April 23, 1984, in a packed press conference room in Washington, DC, the secretary of health and human services declared, “The probable cause of AIDS has been found.” By the next day, “probable” had fallen away, and the novel retrovirus later named HIV became forever lodged in global consciousness as “the AIDS virus.” Celia Farber, then an intrepid young reporter for  SPIN  magazine, was the only journalist to question the official narrative and dig into the science of AIDS. She reported on the “evidence” that was being continually cited a...
Read more

In the world of AIDS fraud it's a case of "choose your poison."

-
Image
Switching Class Inhibitors Might Save Your Life "Switching from one kind of inhibitor to another to treat your HIV could decrease your risks of developing diabetes, obesity, or heart disease, according to a study published recently in the  Journal of Antimicrobial Chemotherapy . The study participants, who were virally suppressed thanks to antiretroviral regimens that included Truvada (tenofovir disoproxil fumarate/emtricitabine) and a ritonavir-boosted protease inhibitor, were switched instead to regimens with an integrase inhibitor (either raltegravir or dolutegravir) and saw improvement in insulin sensitivity, insulin resistance, and serum leptin levels.} https://www.hivplusmag.com/treatment/2019/5/02/switching-class-inhibitors-might-save-your-life Please support HHV-6 University by purchasing one or our books about the cover-up of the relationship between HHV-6 and Chronic Fatigue Syndrome, AIDS, and many other immunological illnesses. Click book to read a ...
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more

Should Kaposi's Sarcoma be added to this list of Chronic Fatigue Syndrome co-morbidities?

-
Image
https://www.frontiersin.org/files/Articles/427132/fped-07-00012-HTML/image_m/fped-07-00012-t006.jpg "Persons infected with KSHV can asymptomatically shed the virus. It is advised to practice safe sex with infected individuals and curtail activities where saliva might be shared during sexual activity." http://www.herpes.com/hhv-8.html This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-di...
Read more

Popular Post in the Last 30 Days

Is African Swine Fever a threat to human health in Congo?

-
Image
https://pmc.ncbi.nlm.nih.gov/articles/PMC7045278/ Our prior reporting on African Swine Fever ASF contaminated meat not entirely safe Besides, ASF-contaminated food could not be entirely safe for humans. “According to the latest research, though the virus is not dangerous to humans, there are documented reactions [of human bodies to ASF] in the form of production of antibodies against it. This indicates an ASF attempt to infect the body and the possibility of a serious weakening of the immune system,” Pavlov said. From 2018 ASF Russia: consumers want liability for sellers of contaminated meat (pigprogress.net) African Swine Fever is a big story already because, when and if it spreads to all of Western Europe and China, it will cause the collapse of a major portion of the agricultural export economies of the affected countries. We're talking about many billions of dollars of losses. And the problem is not temporary because those countries will be suspected of harboring the disease ...
Read more

Multiple forms of Kaposi's Sarcoma and endothelial cell dysfunction may be the link between AIDS, Chronic Fatigue Syndrome, and autism.

-
 If you see  KS and endothelial dysfunction as a link between all of   Long AID/CFS/AUTISM Spectrum Disease,   this is a big deal. JCI - Senescence of endothelial cells increases susceptibility to Kaposi's sarcoma-associated herpesvirus infection via CD109-mediated viral entry Suggests KS has a big bright future. Unfortunately.
Read more

Dr. Rebecca Culshaw Smith's book is discussed on Twitter

-
  #AIDS #HIV #Truvada #TruvadaVictims #ClassAction An eye-opening, heart-breaking investigation. Dr. Rebecca Culshaw Smith's groundbreaking book exposes the tragic reality of 26,000 plaintiffs suing Gilead over the toxic side effects of HIV drug Truvada. https://t.co/PHVoKrafcU pic.twitter.com/hbh3mN4tdI — MyBookLists (@mybooklists) September 12, 2024
Read more

Popular Posts from the Last Year

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more
-
Image
Want to know more about Chronic Fatigue Syndrome? Read The Chronic Fatigue Syndrome Epidemic Cover-up . If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  \ This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue Syndrome" is a mystery for over three decades? By the end of this book of inconvenient truths the answer is crystal clear. The shocking news and bold analysis in this page-turner could lead to a revolution in the science and politics of ...
Read more

If you want to know the whole truth about Chronic Fatigue Syndrome, you need to go Beyond Unrest

-
Image
HHV-6 is discussed in this Chronic Fatigue Syndrome Amazon bestseller on pages 98, 100, 122, 133-135, 143-147, 150, 153, 159, 163, 166, 179, 183, 192, 193, 198, 199, 200, 202, 204, 205, and 211. Ampligen, the breakthrough treatment for Chronic Fatigue Syndrome is discussed in the Amazon bestseller on pages 192, 193, 202, 203, 268, 269, 360, 362, 387, 391, 410, 413, 420, and 421. Anthony Fauci, the architect of the CFS cover-up, is discussed in this Amazon bestseller on pages 71, 103, 104, 26, 130-133, 139, 143, 157, 161, 169-171, 173, 174, 221, 254, 289, 292, 293, 300, 320-322, 324, 335, 356-358, 361, 367, and 398. Dr. Paul Cheney, one of the honest pioneers of Chronic Fatigue Syndrome research is discussed in the Amazon bestseller on pages 145, 146, 155, 166, 192, 219, 225, 226, 232, 242, 244, 326, 327, 352, 402, 434, and 435. Konnie Knox's pioneering research into HHV-6 is discussed in this book on page 428-431. Hillary Johnson's brilliant reporting o...
Read more

More evidence HHV-6 is the cause of Chronic Fatigue Syndrome.

-
HHV-6 encephalopathy associated with structural changes in the olfactory pathway https://hhv-6foundation.org/encephalitis-encephalopathy/hhv-6-encephalopathy-and-ultrastructural-changes-in-the-olfactory-pathway Want to know more about the relationship between HHV-6 and Chronic Fatigue Syndrome? Read The Chronic Fatigue Syndrome Epidemic Cover-up . If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue ...
Read more

The Chronic Fatigue Syndrome and HHV-6 Scientist of the Year

-
Image
Follow @HHV6_University Tweet The scientist who deserves a Nobel Prize for his work on HHV-6 and Chronic Fatigue Syndrome. https://www.uni-wuerzburg.de/en/news-and-events/news/detail/news/viruses-under-the-microscope/ Viruses Under the Microscope 09/14/2018 Human herpesviruses such as HHV-6 can remain dormant in cells for many years without being noticed. When reactivated, they can cause serious clinical conditions. Researchers from Würzburg have now found a way of differentiating between active and inactive viruses.  Human herpesvirus 6 (HHV-6) infects almost all of the human population, but only very few will show any symptoms during their lifetime: HHV-6 is one of the most widespread viruses among the population. Between 95 and 100 percent of healthy adults have antibodies to the virus which means that they have been infected at some point in the past. The virus hides in t...
Read more

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
Read more

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

-
Image
https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more