Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

-


"Clinical investigation found that high concentration of cytokines were detected in the plasma of critically ill patients infected with SARS-CoV-2, suggesting that cytokine storm was associated with disease severity12. Other than its direct antiviral activity, HCQ is a safe and successful anti-inflammatory agent that has been used extensively in autoimmune diseases and can significantly decrease the production of cytokines and, in particular, pro-inflammatory factors. Therefore, in COVID-19 patients, HCQ may also contribute to attenuating the inflammatory response. In conclusion, our results show that HCQ can efficiently inhibit SARS-CoV-2 infection in vitro. In combination with its anti-inflammatory function, we predict that the drug has a good potential to combat the disease. This possibility awaits confirmation by clinical trials. We need to point out, although HCQ is less toxic than CQ, prolonged and overdose usage can still cause poisoning. And the relatively low SI of HCQ requires careful designing and conducting of clinical trials to achieve efficient and safe control of the SARS-CoV-2 infection."
Source:
https://www.nature.com/articles/s41421-020-0156-0?fbclid=IwAR2ppUaJ_PsmUQv8gal83cyIuOSV51SUsyWZYWjYCPUKhh0gGXGRvwyMyy4

Popular Posts in the Last 7 Days

If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? (From Perplexity)

-
 From Perplexity A.I. If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? If one studies all the medical literature on Chronic Fatigue Syndrome and AIDS, what viruses, infections, and pathological findings do they have in common? When reviewing the medical literature on  Chronic Fatigue Syndrome (CFS, also known as Myalgic Encephalomyelitis/ME)  and  AIDS  (Acquired Immunodeficiency Syndrome), several  viruses, infections, and pathological findings  are noted to overlap, though the diseases have distinct etiologies and clinical courses. Viruses and Infections in Common Herpesviruses:  Both conditions are associated with increased prevalence or reactivation of herpesviruses, notably  Cytomegalovirus (CMV)  and  Herpes Simplex Virus (HSV) . In AIDS, CMV is a common opportunistic infection, while in CFS, studies have found higher odd...
Read more

If the nosological definition of AIDS is reset to include all illnesses with serious inflammation regardless of HIV positivity or status, what illnesses could be included in the nosology of AIDS?

-
From Perplexity A.I. If the nosological definition of AIDS is reset to include all illnesses with serious inflammation regardless of HIV positivity or status, what illnesses could be included in the nosology of AIDS? If the nosological definition of AIDS were changed to include all illnesses with serious inflammation regardless of HIV positivity or status, the category would expand dramatically beyond its current, precise meaning. AIDS is currently defined by the presence of HIV infection leading to profound immunodeficiency and a specific set of opportunistic infections and cancers. Chronic inflammation is a hallmark of untreated HIV/AIDS, but it is not unique to it. If “AIDS” were redefined as any illness with serious inflammation, the following types of illnesses could be included: Autoimmune diseases: These are characterized by chronic, often severe inflammation due to the body’s immune system attacking its own tissues. Examples include: Rheumatoid arthritis Systemic lupus erythema...
Read more

We told Perplexity, "Make the case that HHV-8 is the African Swine Fever-like coinfection in AIDS."

-
  From Perplexity A.I. Make the case that HHV-8 is the African Swine Fever-like coinfection in AIDS. Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus, is a well-established coinfection in individuals with HIV/AIDS. The comparison to African Swine Fever Virus (ASFV) draws on parallels in pathogenesis, immune evasion, and the profound impact of coinfection on disease outcomes. Key Parallels Between HHV-8 and African Swine Fever Virus 1. Pathogenic Synergy with Host Immunodeficiency HHV-8 and AIDS: HHV-8 is a major cause of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD), all of which are significantly more aggressive and prevalent in immunocompromised HIV/AIDS patients. ASFV in Swine: ASFV causes severe, often fatal hemorrhagic fever in pigs, especially when host immune defenses are compromised. The virus manipulates host immunity to enhance its replication and spread. 2. Coinfection-Driven Disease...
Read more

HHV-6 in K.S. and AIDS

-
  From Perplexity Make the case that HHV-6 plays an underestimated role in Kaposi's Sarcoma and should be taken more seriously in AIDS. The Underestimated Role of HHV-6 in Kaposi's Sarcoma: A Compelling Case for Recognition in AIDS Human herpesvirus 6 (HHV-6) represents one of the most underappreciated cofactors in AIDS pathogenesis, particularly in its relationship to Kaposi's sarcoma (KS). Despite mounting evidence demonstrating its significant impact on HIV disease progression and cancer development, HHV-6 remains relegated to secondary consideration compared to other opportunistic pathogens. This neglect represents a critical gap in our understanding and management of AIDS-related malignancies. Direct Evidence of HHV-6's Role in Kaposi's Sarcoma Pathogenesis The most compelling evidence for HHV-6's underestimated role comes from experimental studies demonstrating its direct interaction with Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), the establ...
Read more

HHV-6, Chronic Fatigue Syndrome and autism

-
 From Perplexity A.I. Now connect this HHV-6 issue to Chronic Fatigue Syndrome and autism. The Underestimated Connection: HHV-6's Critical Role Linking Chronic Fatigue Syndrome and Autism Through Neuroinflammatory Pathways The relationship between Human Herpesvirus 6 (HHV-6), Chronic Fatigue Syndrome (CFS), and autism spectrum disorders (ASD) represents one of the most compelling yet underappreciated connections in modern neurology and immunology. Building upon the established evidence for HHV-6's role in AIDS and Kaposi's sarcoma, emerging research reveals that this virus serves as a crucial link between CFS and autism through shared mechanisms of neuroinflammation, mitochondrial dysfunction, and immune dysregulation. HHV-6 as a Confirmed Trigger in Chronic Fatigue Syndrome The evidence for HHV-6's causative role in Chronic Fatigue Syndrome has reached compelling levels through multiple independent research streams. A systematic review and meta-analysis of 17 studies e...
Read more

Who has spoken out about HHV-6?

-
From Perplexity A.I. Name the people who have tried the hardest to bring HHV-6 to the public's attention and have paid a price for it. HHV-6B detection and host gene expression implicate HHV ... Human herpesvirus 6 - Wikipedia Dual roles for the telomeric repeats in chromosomally ... Researchers Find Link Between Herpes Strain And ... Several individuals have made significant efforts to bring the importance of HHV-6 to public and scientific attention, often encountering professional skepticism, controversy, or marginalization as a result. Robert Gallo: As one of the original discoverers of HHV-6 in 1986, Gallo and his team at the National Cancer Institute first isolated the virus from AIDS-associated lymphomas while searching for cancer-causing herpesviruses in HIV-infected patients. Their early work suggested HHV-6 might be oncogenic, but the field largely moved on, and the virus remained understudied despite these provocative findings. Kristin Loomis: Founder of the HHV-6 Foundat...
Read more

Consciousness of Guilt in Science and Medicine (From Perplexity A.I.)

-
  Develop the idea that there is something in science and medicine called "consciousness of fraud" (like consciousness of guilt) and list the telltale signs that a scientist is inadvertently showing it. The concept of "consciousness of fraud" in science and medicine parallels legal "consciousness of guilt," reflecting subtle behavioral and linguistic cues that betray a researcher's awareness of misconduct. These involuntary signs manifest through writing patterns, methodological choices, and professional behavior, often revealing attempts to conceal fabricated or manipulated data. Below are key telltale signs, synthesized from empirical studies and expert analyses of scientific fraud: 🔍 Linguistic and Writing Patterns Obfuscation in Language: Fraudulent papers use significantly more jargon, abstract terms, and complex phrasing to obscure methods or results. This "linguistic masking" aims to deter scrutiny, with fraudulent texts containing ~1...
Read more

Popular Post in the Last 30 Days

Consciousness of Guilt in Science and Medicine (From Perplexity A.I.)

-
  Develop the idea that there is something in science and medicine called "consciousness of fraud" (like consciousness of guilt) and list the telltale signs that a scientist is inadvertently showing it. The concept of "consciousness of fraud" in science and medicine parallels legal "consciousness of guilt," reflecting subtle behavioral and linguistic cues that betray a researcher's awareness of misconduct. These involuntary signs manifest through writing patterns, methodological choices, and professional behavior, often revealing attempts to conceal fabricated or manipulated data. Below are key telltale signs, synthesized from empirical studies and expert analyses of scientific fraud: 🔍 Linguistic and Writing Patterns Obfuscation in Language: Fraudulent papers use significantly more jargon, abstract terms, and complex phrasing to obscure methods or results. This "linguistic masking" aims to deter scrutiny, with fraudulent texts containing ~1...
Read more

If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event?

-
 From Perplexity A.I.  If the establishment decides that the nosology of AIDS is wrong and HIV is not the cause of AIDS could that be considered a Black Swan event? If the scientific establishment were to fundamentally revise the current understanding of AIDS and declare that HIV is not the cause, this would indeed constitute a Black Swan event—an extremely rare, unpredictable, and highly consequential occurrence that dramatically alters conventional wisdom and scientific consensus. A Black Swan event is defined by its rarity, profound impact, and the tendency for people to rationalize it retrospectively as if it could have been expected. The current scientific consensus, established in the late 1980s and reinforced by overwhelming evidence, is that HIV is the causative agent of AIDS. This consensus is based on decades of research, clinical experience, and the effectiveness of HIV-targeting treatments. If the establishment were to reverse this consensus, it would be unpreceden...
Read more

We asked Perplexity A.I. to make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS.

-
 From Perplexity A.I. Make the argument that Castleman's Disease undermines the nosology, epidemiology, and virology of AIDS. Castleman disease, particularly its HIV-associated multicentric form (HIV-MCD), challenges core paradigms in AIDS medicine across nosology, epidemiology, and virology. Below is a detailed analysis of how this rare lymphoproliferative disorder complicates established frameworks. 🧬 Nosological Challenges HIV-MCD disrupts traditional AIDS classification by: Blurring diagnostic boundaries: It exhibits inflammatory symptoms (e.g., fever, cytopenia) and histopathology (plasmablastic proliferation) that overlap with—but are distinct from—classic AIDS-defining conditions like lymphoma or opportunistic infections. Dual-pathogen dynamics: Diagnosis requires confirming HHV-8 co-infection, positioning it as a viral co-pathogenesis rather than a direct HIV complication. This contrasts with AIDS nosology, which typically centers on HIV as the primary etiological agent. U...
Read more
-
Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...
Read more

Are any endogenous retroviruses reactivated in AIDS and do any of them act like superantigens?

-
From Perplexity A.I. Are any endogenous retroviruses reactivated in AIDS and do any of them act like superantigens? Yes, several human endogenous retroviruses (HERVs) are reactivated in AIDS, particularly during HIV infection, and some evidence suggests that certain HERV proteins may have superantigen-like activity. Reactivation of HERVs in AIDS/HIV Infection HERV-K (HML-2) is the most studied family and is consistently shown to be upregulated in HIV-infected cells and patients. HIV infection increases HERV-K RNA and protein expression in various cell lines (e.g., U-87 MG, H9 T cells, MT2, Jurkat) and primary CD4+ T cells, often in a dose- and time-dependent manner. Other HERV families such as HERV-E, HERV-W, ERV-9, and subgroups of HERV-K (HML-3, HML-4, HML-10) are also upregulated in HIV infection. The HIV-1 Tat protein plays a key role in activating HERV expression by transactivating HERV-K long terminal repeats (LTRs), opening chromatin structure, and inducing transcription factors...
Read more

Popular Posts from the Last Year

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

-
Image
This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
Read more

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Dr. Rebecca Culshaw Smith's book is discussed on Twitter

-
  #AIDS #HIV #Truvada #TruvadaVictims #ClassAction An eye-opening, heart-breaking investigation. Dr. Rebecca Culshaw Smith's groundbreaking book exposes the tragic reality of 26,000 plaintiffs suing Gilead over the toxic side effects of HIV drug Truvada. https://t.co/PHVoKrafcU pic.twitter.com/hbh3mN4tdI — MyBookLists (@mybooklists) September 12, 2024
Read more

Is African Swine Fever a threat to human health in Congo?

-
Image
https://pmc.ncbi.nlm.nih.gov/articles/PMC7045278/ Our prior reporting on African Swine Fever ASF contaminated meat not entirely safe Besides, ASF-contaminated food could not be entirely safe for humans. “According to the latest research, though the virus is not dangerous to humans, there are documented reactions [of human bodies to ASF] in the form of production of antibodies against it. This indicates an ASF attempt to infect the body and the possibility of a serious weakening of the immune system,” Pavlov said. From 2018 ASF Russia: consumers want liability for sellers of contaminated meat (pigprogress.net) African Swine Fever is a big story already because, when and if it spreads to all of Western Europe and China, it will cause the collapse of a major portion of the agricultural export economies of the affected countries. We're talking about many billions of dollars of losses. And the problem is not temporary because those countries will be suspected of harboring the disease ...
Read more

Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

-
Image
"HHV-6 is actually likely to reduce HIV patient survival by accelerating the depletion of CD4 and CD8 T cells. HHV-6A was shown to accelerate AIDS progression in macaques.  Macaques co-infected with simian HIV and HHV-6A died quickly and showed a dramatic depletion in both CD4+ and CD8+ T cells, whereas those infected with only simian HIV never progressed to full blown AIDS."  "We believe that infections are the most logical explanation for the inflammation neurodegeneration associated with Alzheimer’s , but don’t believe that there is a single pathogen responsible. HHV-6A and HHV-7 were identified as likely culprits in 2018 paper , using RNAseq analysis by Readhead and team. Two subsequent studies did not find an increase in HHV-6/7 using the same data, but at the same time did not find a significant presence of ANY herpesviruses in the brain, which we know is not the case. Dozens of careful studies have identified a high prevalence of low-level HHV-6 and HSV1 DN...
Read more

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

-
Image
https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
Read more

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

-
Image
Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
Read more

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

-
Image
How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
Read more

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

-
Image
https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
Read more