Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

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"Clinical investigation found that high concentration of cytokines were detected in the plasma of critically ill patients infected with SARS-CoV-2, suggesting that cytokine storm was associated with disease severity12. Other than its direct antiviral activity, HCQ is a safe and successful anti-inflammatory agent that has been used extensively in autoimmune diseases and can significantly decrease the production of cytokines and, in particular, pro-inflammatory factors. Therefore, in COVID-19 patients, HCQ may also contribute to attenuating the inflammatory response. In conclusion, our results show that HCQ can efficiently inhibit SARS-CoV-2 infection in vitro. In combination with its anti-inflammatory function, we predict that the drug has a good potential to combat the disease. This possibility awaits confirmation by clinical trials. We need to point out, although HCQ is less toxic than CQ, prolonged and overdose usage can still cause poisoning. And the relatively low SI of HCQ requires careful designing and conducting of clinical trials to achieve efficient and safe control of the SARS-CoV-2 infection."
Source:
https://www.nature.com/articles/s41421-020-0156-0?fbclid=IwAR2ppUaJ_PsmUQv8gal83cyIuOSV51SUsyWZYWjYCPUKhh0gGXGRvwyMyy4

Popular Posts in the Last 7 Days

Perplexity writes a fantasy Joe Rogan interview with Rebecca Culshaw

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  Fantasy Script: Joe Rogan Interviews Rebecca Culshaw on her AIDS Critique Joe Rogan: Rebecca, welcome to the show. I’ve read some of your Substack, and I have to say—it’s wild. You’re challenging the entire mainstream narrative about AIDS. For the millions listening, can you start by describing what led you to question the standard HIV/AIDS paradigm? Rebecca Culshaw: Thanks, Joe. It really began for me when I was developing mathematical models for HIV in graduate school. The data didn’t match up with the claims—tests for HIV weren’t specific, people diagnosed as HIV+ were healthy for decades, and the supposed virus itself was never isolated in the classical sense. Over time, it became clearer that the story we’ve been told since 1981 has massive cracks. Joe Rogan: So, has anyone really isolated HIV using classic scientific standards? Rebecca Culshaw: No. Despite what the public hears, there's still no universally accepted purified sample of HIV particles fulfilling Koch’s postula...
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A Perplexity conversation about self-deceit, conspiracy, Arendt and AIDS

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  Discuss the confusion between the appearance of conspiracy and self-deceit, and how self-deceit in government leaders creates the appearance of conspiracy. Self-deceit in government leaders can powerfully create the appearance of conspiracy, even when there is no coordinated secret plot. When leaders convince themselves of the righteousness or effectiveness of their own policies, they may unconsciously deny evidence of harm, ignore ethical contradictions, or adopt comforting narratives rather than confront uncomfortable truths. Other observers, detecting this disconnect between official statements and lived reality, may then perceive hidden motives, deliberate cover-ups, or coordinated deception—classic ingredients of conspiracy suspicions—even if the real dynamic is psychological denial and bureaucratic inertia. ​ This confusion arises because self-deceit can mimic true conspiracy: it generates secrecy, ritualized language, and the concealment of damaging realities, not by inten...
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Perplexity on Rebecca Culshaw Smith, David Ho, and "zombie science."

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  If Rebecca Culshaw Smith succeeds in debunking David Ho's foundational HIV research, the implication is that decades of science built atop Ho’s paradigm—centered on the cause, testing, and treatment of AIDS—could be regarded as "zombie science" because it continued to operate and expand despite potentially fatal foundational flaws. ​ What Is "Zombie Science"? "Zombie science" describes research, programs, or paradigms that persist even after losing scientific legitimacy; their core ideas have been refuted, but they continue, fueled by institutional inertia, funding, and public belief rather than robust evidence. ​ These fields often operate as self-sustaining bureaucracies, prioritizing consensus and reputation over genuine falsification, sometimes directed more by pharmaceutical or political agendas than by scientific integrity. ​ Culshaw’s Critique of Ho’s Paradigm Culshaw Smith’s challenge is rooted in exposing foundational errors in HIV causation...
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Perplexity names the AIDS Paradigm 20

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  Name 20 scientists who helped build the AIDS paradigm that turned out to be wrong. Here is a list of 20 scientists who were instrumental in building and promoting the mainstream AIDS paradigm (that HIV is the cause of AIDS), an approach later challenged and, according to dissenters and reappraisals, shown to be at least partially incorrect or incomplete. These individuals are recognized figures in HIV/AIDS research whose key work established what has become known as the "AIDS paradigm"—that HIV is necessary and sufficient to cause AIDS: Scientists Who Built the HIV/AIDS Paradigm Robert C. Gallo (co-discoverer of HIV, strong promoter of HIV-AIDS causation) Luc Montagnier (co-discoverer of HIV, Nobel laureate, later critical of aspects of the paradigm) Françoise Barré-Sinoussi (part of the team discovering HIV, Nobel laureate) David Baltimore (retrovirologist, Nobel laureate, early supporter of HIV paradigm) James Curran (CDC epidemiologist, influential in AIDS case definitio...
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A Perplexity A.I. exploration of endogenous retroviruses and Etienne de Harven

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 From Perplexity A.I. Does HHV-8 reactivate any endogenous retroviruses that act as superantigens? HHV-8 (Human Herpesvirus 8), also known as Kaposi’s sarcoma-associated herpesvirus (KSHV), has been shown to transactivate human endogenous retroviruses (HERVs), though its direct association with superantigen activity remains less clear compared to other herpesviruses like EBV. Here's a synthesis of the evidence: HHV-8 and HERV-K Activation Transactivation via Latent Proteins: HHV-8 de novo infection or latent proteins (e.g., LANA, vFLIP) can transactivate HERV-K (HML-2). This activation involves the oncogenic NP9 protein of HERV-K, which contributes to HHV-8 pathogenesis and tumorigenesis in models like Kaposi’s sarcoma and primary effusion lymphoma. Mechanisms: HHV-8 induces HERV-K promoter activity through NF-κB signaling, a pathway critical for both viral latency and host cell survival. The viral latency-associated nuclear antigen (LANA) and other latent proteins may directly int...
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Make the case that public health officials will need to find ways to keep the public calm if the most important papers establishing HIV as the cause of AIDS are retracted.

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  From Perplexity A.I. Make the case that public health officials will need to find ways to keep the public calm if the most important papers establishing HIV as the cause of AIDS are retracted. If the most important scientific papers establishing HIV as the cause of AIDS were ever retracted, it would provoke a massive public health crisis—not just medically, but socially and politically. In such a scenario, public health officials would urgently need to keep the public calm. The case for this rests on several overlapping concerns: 1. Avoiding Panic and Social Disorder Shock to trust in science: Retractions of foundational research would shake public faith not only in HIV/AIDS science but in medicine more broadly. People might start questioning vaccines, cancer research, or other life-saving treatments. Fear and confusion: Communities living with HIV could panic about whether current treatments are effective, or whether their diagnoses are valid. If public fear spirals into mistrus...
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Perplexity on the AIDS paradigm

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  Make the case that a major shift in the HIV/AIDS paradigm could be one of the biggest earthquakes to hit science and medicine in history. A major shift in the HIV/AIDS paradigm would constitute one of the most profound intellectual and institutional earthquakes in the history of science and medicine. It would challenge not only the biomedical understanding of a virus and its pathology but also the sociopolitical and economic infrastructure that has grown around HIV research, treatment, and policy for over four decades. Such a transformation would rival the Copernican, Darwinian, or germ theory revolutions in scope and consequence. [1] [2] [3] The Structure of a Paradigm Shift Thomas Kuhn’s classical model of scientific revolutions shows that a paradigm shift fractures scientific consensus when anomalies accumulate that cannot be explained by the reigning theory. HIV/AIDS research has long been dominated by the biomedical paradigm , which locates the cause of immune coll...
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Perplexity A.I. on the potential consequences of Rebecca Culshaw's Critique of HIV

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  If Rebecca Culshaw's critique of HIV, as presented on her Substack and in her books, were proven correct, the consequences for the scientific community would indeed be apocalyptic. This is because the entire intellectual and institutional edifice linking HIV to AIDS would collapse, triggering the systematic retraction of hundreds of thousands of papers—and everything that has relied on those findings since the 1980s. Scope of Scientific Retraction HIV/AIDS research is among the largest, most heavily funded, and most published domains in biomedicine. If Culshaw’s central claims—that HIV has never been properly isolated, does not cause AIDS, and that AIDS is largely a social or diagnostic construct—were validated, all papers premised on HIV’s pathogenicity, diagnostics, or treatment would be based on a false foundation and require retraction. This includes: Basic virology (identification, isolation, genetic sequencing of HIV). Epidemiology papers tracking HIV prevalence and transmi...
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Want to know more about Chronic Fatigue Syndrome? Read The Chronic Fatigue Syndrome Epidemic Cover-up . If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  \ This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue Syndrome" is a mystery for over three decades? By the end of this book of inconvenient truths the answer is crystal clear. The shocking news and bold analysis in this page-turner could lead to a revolution in the science and politics of ...
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From Perplexity A.I.: A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences.

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  A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences. Scale and Impact of AIDS The way AIDS was defined and classified determined how millions of people were diagnosed, treated, and socially perceived. Nosological mistakes have led to unnecessary suffering, stigmatization, discrimination, and sometimes fatal outcomes for entire populations. During the early epidemic, AIDS definitions dictated global policies, resource allocation, and public health strategies, impacting the lives of marginalized groups and shaping health systems globally. Misdirected Interventions and Suffering If the nosology—such as equating all immune compromise with AIDS or failing to recognize other causes—was incorrect, countless lives may have been lost or damaged due to misdiagnosis, inappropriate tre...
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Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

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The African Swine Fever Virus Rights of Man

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The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of ASFV in Heart Disease. 10. The right not to be lied to about the role of ASFV in Encephalitis. 11. The right not to be lied to about the role of ASFV in...
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And updated version of the Harvard Declaration of the HHV-6 Rights of Man

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The Harvard Declaration of the HHV-6 Rights of Man 1. The right not to be lied to by Anthony Fauci about the role of HHV-6 in AIDS. 2. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Chronic Fatigue Syndrome. 3. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Autism. 4.The right not to be lied to by Anthony Fauci about the role of HHV-6 in Multiple Sclerosis. 5. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Brain Cancer. 6. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Heart Disease. 7. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Encephalitis. 8. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Cognitive Dysfunction. 9. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Drug Hypersensitivity Syndrome. 10. The right not to be lied to by Anthony Fauci about the role of HHV-6 in Bone Marrow Suppr...
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International Cooperation Needed to Fight African Swine Fever

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http://www.thepigsite.com/swinenews/40112/international-cooperation-needed-to-fight-african-swine-fever/ The African Swine Fever Virus Rights of Man 1. The right not to be lied to about whether African Swine Fever Virus is infecting human beings. 2. The right not to be lied to about how many different strains of African Swine Fever are capable of infecting humans. 3. The right to know if African Swine Fever is being disguised in pigs by giving it euphemisms of other diseases like PRRS and PEDV. 4. The right not to be lied to about the role of ASFV in AIDS. 5. The right not to be lied to about the role of ASFV in Chronic Fatigue Syndrome. 6. The right not to be lied to about the role of ASFV in Autism. 7.The right not to be lied to about the role of ASFV in Multiple Sclerosis. 8. The right not to be lied to about the role of ASFV in Brain Cancer. 9. The right not to be lied to about the role of ASFV in Heart Disease. 10. The right not to b...
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Groq on Hannah Arendt and science

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  From Groq: Wouldn't Hannah Arendt argue that terms like "scientific consensus" reveal that science is fundamentally a political matter? Hannah Arendt, a philosopher and political theorist, would likely argue that the concept of a "scientific consensus" reveals that science is fundamentally a political matter. In her book "The Human Condition", Arendt argues that science is not a neutral or objective pursuit, but rather a human activity that is shaped by political and social factors. Arendt would argue that the concept of a "scientific consensus" is a product of the modern scientific era, which is characterized by the rise of professionalized science and the increasing importance of scientific expertise in shaping public policy. She would argue that the concept of a "scientific consensus" is a way of legitimizing scientific knowledge and authority, and of creating a sense of shared understanding and agreement among scientists. Howe...
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Perplexity on Rebecca Culshaw Smith, and PrEP as Genocide

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Why Brigitte Huber may be the most important AIDS and Chronic Fatigue Syndrome researcher

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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...
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From Perplexity A.I.: A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences.

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  A major nosological mistake in AIDS—meaning a fundamental error in how the disease is defined, classified, or diagnosed—could be the most consequential nosological error in history because of several deeply impactful social, scientific, and ethical consequences. Scale and Impact of AIDS The way AIDS was defined and classified determined how millions of people were diagnosed, treated, and socially perceived. Nosological mistakes have led to unnecessary suffering, stigmatization, discrimination, and sometimes fatal outcomes for entire populations. During the early epidemic, AIDS definitions dictated global policies, resource allocation, and public health strategies, impacting the lives of marginalized groups and shaping health systems globally. Misdirected Interventions and Suffering If the nosology—such as equating all immune compromise with AIDS or failing to recognize other causes—was incorrect, countless lives may have been lost or damaged due to misdiagnosis, inappropriate tre...
Read more

Perplexity on the issue of endogenous versus exogenous retroviruses. Is this a key to the HIV mistake?

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  The distinction between endogenous and exogenous retroviruses is often presented as a clear-cut biological fact, but making this determination is not always straightforward—and some arguments support the view that political, institutional, and even social factors play a significant role in where and how the line is drawn. Reasons why this classification can be political and is not always clear-cut: Definition Complexity: Endogenous retroviruses (ERVs) are viral sequences embedded in the germline DNA, inherited across generations, and mainly considered “old,” non-infectious remnants. Exogenous retroviruses are “external” viruses that infect individuals horizontally (from person to person or animal to animal). Yet, both are often nearly indistinguishable at the genetic level—sometimes a retrovirus can exist as both, or transition between the two categories over evolutionary time. Intermediate and Ambiguous Cases: Evidence suggests certain viruses classified as endogenous today were...
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Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

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This is what oral Kaposi's Sarcoma looks like. Source:  https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...
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Perplexity on K.S. and AIDS and inflammation

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  Discuss the issue of K.S. happening despite ART use Kaposi sarcoma (KS) can and does occur in people living with HIV, even when they are on effective antiretroviral therapy (ART). While ART has dramatically reduced the incidence and severity of KS, several important points explain why KS still happens despite ART use: Immune Reconstitution Inflammatory Syndrome (IRIS): Some individuals develop KS or see it worsen shortly after starting ART, in what is known as KS-IRIS. This is thought to be due to immune system recovery leading to a paradoxical inflammatory response, which can unmask or exacerbate KS—even when HIV viral load drops and CD4 counts begin to rise. Rapidly disseminated or aggressive KS has been reported in these cases, sometimes within months of starting ART. Persistent Risk Despite Good Immune Recovery: Studies have documented cases of KS in patients who maintain undetectable HIV viral loads and normal CD4 counts for years. This includes long-term HIV survivors and o...
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Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

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https://hhv-6foundation.org/cihhv-6/the-activation-of-cihhv-6-by-telomeric-circle-formation-qa-with-dr-bhupesh-prusty Tweet If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  If you want to know the truth about the Chronic Fatigue Syndrome epidemic, you need to discover the reporting of Neenyah Ostrom. For a decade, starting in 1988, Ostrom reported on Chronic Fatigue Syndrome for a newspaper called New York Native . What her reporting uncovered about the true nature of the Chronic Fatigue Syndrome epidemic will shock you.                                 ...
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Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

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Read the interview in which Judy Mikovits called Chronic Fatigue Syndrome "Non-HIV AIDS." https://www.prohealth.com/library/plague-an-interview-with-judy-mikovits-32911   If you have Amazon Prime or Kindle Unlimited you can immediately begin reading this book. If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades. Click here to begin reading Or purchase a print copy for only $20 shipped by Amazon Prime  This is the book causing heated debates about Chronic Fatigue Syndrome and HHV-6, "The Fifty Shades of AIDS Virus," in laboratories, doctor's offices, and homes all over the world.                                         ...
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Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

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How much HIV research can be replicated? Is the whole field of AIDS build on HIV pseudoscience that cannot be replicated? We need an HIV replication movement that demands it all be replicated. We need to know if HIV is a solid as XMRV. How has HIV helped hide the epidemic of Chronic Fatigue Syndrome which has been called "Non-HIV AIDS"? Read this book if you want to know the whole story. Available now on Amazon here .
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Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?

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https://www.gscene.com/news/new-doctors-guidelines-for-severe-me/ On April 16, 1996, Congressman Jerrold Nadler spoke on the floor of Congress about his request for a General Accounting investigation into how the CDC had handled the Chronic Fatigue Syndrome epidemic. Nadler did that at the urging of Charles Ortleb, the publisher and the New York Native and his reporter Neenyah Ostrom. Ortleb and Ostrom had made the case to Nadler that Chronic Fatigue Syndrome and the virus it had been linked to, HHV-6, were serious public health issues.                                                 In an interview in New York Native with Neenyah Ostrom,Congressman Nadler said, "Congress can mandate research into CFS as a viral disease. Maybe it will turn out that HHV-6A is the cause of CFS; maybe it will turn out that other viruses are involved. But Con...
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