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Human Herpesvirus 6 Infection of CD4+ T-Cell Subsets

http://onlinelibrary.wiley.com/doi/10.1111/j.1348-0421.2007.tb03996.x/pdf

Important statement by the HHV-6 Foundation on HHV-6 and AIDS

http://hhv-6foundation.org/news/humanized-mouse-model-demonstrates-hhv-6a-infection-can-cause-significant-immune-dysfunction

HHV-6 in AIDS

 http://www.ncbi.nlm.nih.gov/pubmed/24006442 J Virol. 2013 Nov;87(22):12020-8. doi: 10.1128/JVI.01556-13. Epub 2013 Sep 4. Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2-/-γc-/- Mice. Tanner A , Carlson SA , Nukui M , Murphy EA , Berges BK . Source Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah, USA. Abstract Although serious human diseases have been correlated with human herpesvirus 6A (HHV-6A) and HHV-6B, the lack of animal models has prevented studies which would more definitively link these viral infections to disease. HHV-6A and HHV-6B have recently been classified as two distinct viruses, and in this study we focused specifically on developing an in vivo model for HHV-6A. Here we show that Rag2(-/-)γc(-/-) mice humanized with cord blood-derived human hematopoietic stem cells produce human T cells that express the major HHV-6A receptor, CD46. Both cell-associated and cell-free viral tran

March 8, 1993 / Human Herpesvirus Type 6 and Chronic Fatigue Syndrome

http://archinte.jamanetwork.com/article.aspx?articleid=617124&resultClick=1

Possible Role of Human Herpesvirus 6 as a Trigger of Autoimmune Disease

http://www.hindawi.com/journals/tswj/2013/867389/

In this study, we detected the viral DNA of Human Herpes Virus 6 (HHV-6) in the sera and cell-free cerebrospinal fluid (CSF) of Chinese multiple sclerosis (MS) patients

http://www.bioportfolio.com/search/T-cell-recall-and-cross-reactivity.html

Possible role of HHV-6 as a trigger of Autoimmune disease

http://www.hindawi.com/journals/tswj/aip/867389/

Chimerix Initiates Phase 3 SUPPRESS Trial of Brincidofovir (CMX001) for Prevention of Cytomegalovirus in Hematopoietic Cell Transplant Recipients

http://www.healthtechnologynet.com/articles/viewarticle.jsp?id=2796030&type=home

Sensitivity of human herpesvirus 6 and other human herpesviruses to the broad-spectrum antiinfective drug artesunate.

http://www.ncbi.nlm.nih.gov/pubmed/19501020

Conditions associated with HHV-6

http://hhv-6foundation.org/conditions-associated-with-hhv-6

Dan Peterson on Antiviral Treatment for HHV-6 (2008)

Video #1 Video #2

Human Herpesvirus 6 Infection of the Gastroduodenal Mucosa

"HHV-6–positive cells and CMV-positive cells were frequently found in the gastroduodenal mucosa of liver transplant recipients and of immunocompetent patients undergoing gastroscopic examination because of dyspeptic symptoms." Leena Halme, Johanna Arola, Krister Höckerstedt, and Irmeli Lautenschlager http://cid.oxfordjournals.org/content/46/3/434.full

Infection of murine oligodendroglial precursor cells with Human Herpesvirus 6 (HHV-6) — establishment of a murine in vitro model

odel David J. Mock et. al. Abstract Background Human Herpesvirus 6 was previously demonstrated to infect human oligodendroglial precursor cells (OPCs) in vitro causing cell cycle arrest and premature differentiation with consequent loss of the precursor pool. Objectives To develop an in vitro murine OPC model to study the cell cycle and differentiation effects of HHV-6 in more readily available, genetically well-defined cells free of the risk of contamination with human herpesviruses. Study design Murine OPCs were exposed to infectious HHV-6A or HHV-6B and analyzed for production of viral transcripts, particles, and replicating virus. FACS analysis and specific markers were used to evaluate effects on cell cycling and differentiation. Results HHV-6 infection of murine OPCs resulted in production of both immediate-early and some late transcripts but no replicating virus by TaqMan quantitative PCR or electron microscopy. Both a specific G1/S cell cycle a

HHV-6 Virus May Enter Brain via Nose, Say Experts

http://topnews.us/content/242425-hhv-6-virus-may-enter-brain-nose-say-experts

HHV-6 and Autism

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Multisystemic HHV-6 and Antiphospholipid Syndrome Autoantibodies in Autism Are Autism Spectrum Disorders part of the Multisystemic HHV-6 Spectrum of Disorders? Is the Multisystemic HHV-6 Epidemic Causing the Dramatic Rise in Autism? Can the complications of Autism Spectrum Disorder be reduced by controlling Multisystemic HHV-6? Why won't the Centers for Disease Control tell the truth about the role of Multisystemic HHV-6 in Autism, Chronic Fatigue Syndrome, AIDS and many other serious neuroimmunological syndromes? What exactly is Multisystemic HHV-6? Is it really just a reactivated herpes virus or is it actually some other kind of lethal virus that can be passed from person to person and can become chromsomally integrated? Does it belong in a class by itself? Where did it come from? Is it a zoonose, a virus that is circulating in people and animals? "About six weeks back I was given the name of a woman who had approached Generation Rescue. She has a foun

Chorea and developmental regression associated with human herpes virus-6 encephalitis.

http://www.ncbi.nlm.nih.gov/pubmed/23419479

The complications of the HHV-6 epidemic become more and more widespread

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HHV-6 in Alzheimer's disease: relation to progression of the disease  http://www.ncbi.nlm.nih.gov/pubmed/23916950    

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