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Showing posts with the label human herpes virus 6

HHV-6 New York Native Flashback #3

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"Cheney also find antibodies to Human B-Lymphotropic Virus (HBLV, or Human Herpes Virus-6) in his [chronic fatigue syndrome] patients.(Cheney has done virologic and serologic studies on patients from his previous practice in Lake Tahoe, Nevada and his current patients in Charlotte, North Carolina; he stated at the conference that they were 'identical.') He has looked at the distribution of antibodies to HHV-6, and has found that [chronic fatigue syndrome] patients lie outside the normal range, both high and low. Those who have high levels of antibodies display symptoms that resemble mononucleosis, those with low levels have symptoms similar to multiple sclerosis. Cheney commented that if these symptoms do progress to clinical multiple sclerosis, it will take ten years to demonstrate that progression conclusively."    -- Neenyah Ostrom, New York Native , November 14, 1988                ...

Is this how HHV-6 causes cancer, one of HHV-6's 50 Shades of AIDS?

Study reveals how a cancer-causing virus blocks human immune response    http://www.eurekalert.org/pub_releases/2015-01/uota-srh012115.php

Gut-Brain Dysfunction: One of HHV-6's 50 Shades of Non-HIV AIDS

Autonomic nervous system dysregulation in irritable bowel syndrome http://onlinelibrary.wiley.com/doi/10.1111/nmo.12512/abstract Conclusions & Inferences IBS subjects display a significant reduction in α index, an established marker of cardiac baroreflex. ANS dysfunction appears to be involved in the pathophysiology of IBS and its assessment may open new perspectives for clinical management of patients suffering from IBS.

Immunomodulation and immunosuppression by human herpesvirus 6A and 6B

http://www.futuremedicine.com/doi/abs/10.2217/fvl.13.7 Lorenzo Dagna Joshua C Pritchett & Paolo Lusso Future Virology Vol. 8, No. 3, Pages 273-287 , DOI 10.2217/fvl.13.7 (doi:10.2217/fvl.13.7)    "Like other members of the Herpesviridae family, human herpesvirus (HHV)-6A and HHV-6B have developed a wide variety of strategies to modulate or suppress host immune responses and, thereby, facilitate their own spread and persistence in vivo . Long considered two variants of the same virus, HHV-6A and HHV-6B have recently been reclassified as distinct viral species, although the established nomenclature has been maintained. In this review, we summarize the distinctive profiles of interaction of these two viruses with the human immune system. Both HHV-6A and HHV-6B display a tropism for CD4 + T lymphocytes, but they can also infect, in a productive or nonproductive fashion, other cells of the immune system. However, there are...

The Torture Report

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If you like our cartoons, you'll love Julian Lake's collection: The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies. [Kindle Edition available on Kindle Unlimited] The title of this collection of cartoons by Julian Lake was inspired by the The March of Folly , a stunning work by the late Barbara Tuchman. To try and explain why certain political disasters in history have occurred, Tuchman uses the very apt construct of "folly," which she defines as the "pursuit of policy contrary to the self-interest of the constituency or state involved." Tuchman analyzes four periods in history that are characterized by enormous folly. Julian Lake's collection is in many ways about a fifth example of such a phenomenon. Surely the last two decades in which so-called "Chronic Fatigue Syndrome" has been called "mysterious" over and over in a cult-like manner (and in the manner of the Big Lie) qual...

Chronic Fatigue Syndrome subsets

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If you like our cartoons, you'll love Julian Lake's collection: The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies. [Kindle Edition available on Kindle Unlimited] The title of this collection of cartoons by Julian Lake was inspired by the The March of Folly , a stunning work by the late Barbara Tuchman. To try and explain why certain political disasters in history have occurred, Tuchman uses the very apt construct of "folly," which she defines as the "pursuit of policy contrary to the self-interest of the constituency or state involved." Tuchman analyzes four periods in history that are characterized by enormous folly. Julian Lake's collection is in many ways about a fifth example of such a phenomenon. Surely the last two decades in which so-called "Chronic Fatigue Syndrome" has been called "mysterious" over and over in a cult-like manner (and in the manner of the Big Lie)...

HHV-6 Treatment Breakthough for Chronic Fatigue Syndrome, AIDS, MS and Other HHV-6 Diseases?

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http://www.ncbi.nlm.nih.gov/pubmed/23669381 Synthesis and Antiviral Activity of Methylenecyclopropane Analogs with 6-alkoxy and 6-alkylthio Substitutions that Exhibit Broad Spectrum Antiviral Activity against Human Herpesviruses. Prichard MN,  Williams JD, Komazin-Meredith G, Khan AR, Price NB, Jefferson GM, Harden EA, Hartline CB, Peet NP, Bowlin TL. Source University of Alabama at Birmingham, Birmingham Alabama. Abstract  Methylenecyclopropane nucleosides have been reported to be active against many of the human herpesviruses. The most active compound of this class is cyclopropavir (CPV), which exhibits good antiviral activity against human cytomegalovirus (HCMV), Epstein Barr virus, both variants of human herpesvirus 6, and human herpesvirus 8 . CPV has two hydroxylmethyl groups on the methylenecyclopropane ring, but analogs with a single hydroxymethyl group, such as the prototypical (S)-synguanol, are also active and exhibit a broader spectrum of antiviral activi...

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