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Where the retrovirus in Chronic Fatigue Syndrome is coming from

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HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashic, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, ...

Autoimmunity caused by endogenous reroviruses: One of HHV-6's 50 Shades of Non-HIV AIDS?

The role of human endogenous retroviruses in the pathogenesis of autoimmune diseases.   http://www.researchgate.net/publication/225078810_The_role_of_human_endogenous_retroviruses_in_the_pathogenesis_of_autoimmune_diseases   Brigitte Huber on HHV-6 and an endogenous retrovirus.

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