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Tuesday, June 30, 2020

Will new Swine Flu concerns force China to test its pigs for SARS-CoV-2?

Flu virus with 'pandemic potential' found in China

The ACE2 receptors in pigs might indicate that pigs are a big issue for COVID-19  

ACE2 receptors have been shown to be the entry point into human cells for some coronaviruses, including the SARS virus. A number of studies have identified that the entry point is the same for SARS-CoV-2, the COVID-19 virus.

Dr Helena Maier, from the Pirbright Institute, said: 'Coronaviruses are a family of viruses that infect a wide range of different species including humans, cattle, pigs, chickens, dogs, cats and wild animals

Will this video force scientists to consider pigs as the possible intermediate vectors of Covid-19?

Microbiologist Florian Krammer suggests pigs might be the intermediate vectors of SARS-CoV-2

Prof. Florian Krammer received his advanced training in biotechnology and applied virology at the University of Natural Resources and Life Sciences, Vienna (Mentor: Dr. Reingard Grabherr), where he gained extensive experience with expression and purification of recombinant (glyco-) proteins and influenza virus-like particles. He established various expression systems for these proteins using insect cells/baculovirus, mammalian cells, bacteria, yeast and plants. Furthermore, he worked on a novel influenza virus rescue system based on baculovirus transduction of mammalian cells and a novel bioassay to measure inhibition of the influenza virus polymerase complex by cap-snatching inhibitors. He graduated from the University of Natural Resources and Life Sciences, Vienna in 2010.

Prof. Krammer’s post-doctoral work in the laboratory of Dr. Peter Palese at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai, New York focused on the development of broadly neutralizing anti-hemagglutinin stalk antibodies and the design of an universal influenza virus vaccine. The results of these studies have been very promising: After successful testing in animal models (mice, ferrets), studies with this universal influenza virus vaccine are now advancing to human clinical trials.

Currently Prof. Krammer holds a position as a Professor of Vaccinology at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. He has published more than 100 papers, is member of the editorial boards of the Journal of VirologyPlos One and Heliyon and is a peer reviewer for more than 30 journals. Dr. Krammer is also member of the Vaccine and Edward Jenner Society Young Investigator Program. In addition he is a scientific adviser for enGenes and PathSensors.

Since 2019, Prof. Krammer is the Principal Investigator of the Sinai-Emory Multi-Institutional Collaborative Influenza Vaccine Innovation Center (SEM-CIVIC). Our CIVIC aims to develop improved seasonal and universal influenza virus vaccines that induce long lasting protection against drifted seasonal, zoonotic and future pandemic influenza viruses.

The Krammer laboratory – which is also part of the NIH-funded Centers for Excellence in Influenza Research and Surveillance (CEIRS) – focuses on understanding broadly-reactive immune responses against the surface glycoproteins of RNA viruses such as influenza with the goal to develop better vaccines and novel therapeutics.


The Bortz Virology Group supports investigating possible SARS-CoV-2 infection of pigs

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It's not rocket science.

It's not rocket science.

Can the new African Swine Fever test detect the virus in humans?

African Swine Fever is a big story already because, when and if it spreads to all of Western Europe, all of Asia and the USA (where it may already be in pigs), it will cause the collapse of a major portion of the agricultural export economies of the affected countries. We're talking about many billions of dollars of losses. And the problem is not temporary because those countries will be suspected of harboring the disease in their wild boar and ticks for decades to come. The disease could easily become endemic. 

But the issue is so much more important because of the disturbing body of evidence that shows that African Swine Fever Virus can infect humans (despite what authorities currently insist). Thus far, Europe and America's leading publications and journalists have failed to warn the public of the impending ASFV risk to their health. Here are the biggest African Swine Fever stories they have missed.

1. The African Swine Fever Vaccine for humans.

"African Swine fever is an endemic disease in sub-Saharan Africa and many other parts of the developing world. It is caused by the African Swine virus that primarily replicates in macrophages and monocytes leading to the impairment of the structure and function of the immune system of the infected organisms. Until now the African Swine epidemic continues to spread despite all efforts to contain it. Thus, there is an objective need for effective, safe and affordable preventive and therapeutic approaches, in particular for effective vaccines, to control and eventually eradicate this disease. Since the characteristic feature of the African Swine virus is to impair the immune system and to cause immune deficiencies in its hosts the development of vaccines and other therapeutic approaches against the African Swine virus has implications for other immune deficiencies or diseases. Several other viruses are also known to cause immunodeficiency-like syndromes in humans, including cytomegalovirus, Epstein Barr Virus and others. Moreover, a series of cases of so-called "idiopathic" immunodeficiencies have been documented that display CD4+T-lymphocytopenia with opportunistic infections, but show no evidence of HIV infection. Since antibodies for the African Swine virus have been detected in humans, the possibility of human infection with the African Swine virus exists and may thus far have escaped any systematic screening. Thus, any preventive and therapeutic approach to African Swine fever can have far-reaching implications to control immune deficiency conditions in humans."

2. Evidence of African Swine Fever found in people with fevers.

Virus Identification in Unknown Tropical Febrile Illness Cases Using Deep Sequencing

Dengue virus is an emerging infectious agent that infects an estimated 50–100 million people annually worldwide, yet current diagnostic practices cannot detect an etiologic pathogen in ∼40% of dengue-like illnesses. Metagenomic approaches to pathogen detection, such as viral microarrays and deep sequencing, are promising tools to address emerging and non-diagnosable disease challenges. In this study, we used the Virochip microarray and deep sequencing to characterize the spectrum of viruses present in human sera from 123 Nicaraguan patients presenting with dengue-like symptoms but testing negative for dengue virus. We utilized a barcoding strategy to simultaneously deep sequence multiple serum specimens, generating on average over 1 million reads per sample. We then implemented a stepwise bioinformatic filtering pipeline to remove the majority of human and low-quality sequences to improve the speed and accuracy of subsequent unbiased database searches. By deep sequencing, we were able to detect virus sequence in 37% (45/123) of previously negative cases. These included 13 cases with Human Herpesvirus 6 sequences. Other samples contained sequences with similarity to sequences from viruses in the Herpesviridae, Flaviviridae, Circoviridae, Anelloviridae, Asfarviridae, and Parvoviridae families. In some cases, the putative viral sequences were virtually identical to known viruses, and in others they diverged, suggesting that they may derive from novel viruses. These results demonstrate the utility of unbiased metagenomic approaches in the detection of known and divergent viruses in the study of tropical febrile illness.

3. A Russian Scientist warns that African Swine Fever could infect humans.

Russian Scientist: ASF could become a human health risk

"The African swine fever (ASF) virus, may in the future become dangerous for humans, according to the head of the Russian Epidemiology Service, Chief State Sanitary Doctor Gennady Onishchenko, at the press-conference in St. Petersburg. According to him almost all viruses from time to time go through mutation processes which can give them some additional functions."

4. Detection of Novel Sequences Related to African Swine Fever Virus in Human Serum and Sewage.
Loh J, Zhao G, Presti RM, Holtz LR, Finkbeiner SR, Droit L, Villasana Z, Todd C, Pipas JM, Calgua B, Girones R, Wang D, Virgin HW.

Departments of Pathology & Immunology and Molecular Microbiology, Department of Medicine and Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Microbiology, Faculty of Biology, University of Barcelona, Barcelona, Spain.

"The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks, but has not been reported to infect humans. We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the Asfarvirus family, but highly divergent from ASFV. Detection of these sequences suggests that greater genetic diversity may exist among Asfarviruses than previously thought, and raises the possibility that human infection by Asfarviruses may occur."

5. How the American science Robert Gallo may have stolen the African Swine Fever research of a Boston University scientist and may have given African swine Fever the fraudulent new name of "HHV-6."

"In August, 1986, John Beldekas was invited to go to the NCI and present his findings on the link between ASFV [African Swine Fever virus] and AIDS, which he did. Beldekas gave samples of all his lab work to Gallo. Later, the government asked Beldekas to turn over all his reagents and lab work to the government, which he did. Beldekas had found ASFV presence in nine of 21 AIDS patients using two standard procedures. At the meeting, Gallo was reported saying: “we know it is not ASFV.” How could Gallo know this as he hadn’t done any of his own tests to look for ASFV?
Two months later, Gallo published an article in Science (Oct 31, 1986) that he discovered a new possible co-factor in AIDS, a virus he called Human B Cell Lymphotropic Virus which he named HBLV. Like ASFV, HBLV infected B cells and also lived in macrophages. Did Gallo steal Beldekas’s ASF virus he found in AIDS patients and rename it HBLV? Later on, when Gallo found that HBLV could also infect other immune cells, he changed the name of HBLV to HHV-6. Eventually, Gallo identified his HBLV as the variant A strain of HHV-6 and called it a human herpesvirus."
--Mark Konlee

6. The epidemiology that suggests that African Swine Fever in people in Sardinia is misidentified as HHV-8.

The world's highest incidence of Kaposi's sarcoma occurs in Sardinia (Reference) Is it possible that it is due to the fact that African Swine Fever Virus is endemic on the island? (Reference) One study suggests that the incidence of K.S. in northern Sardinia is highest in a countryside area where people have contact with animals. (Reference) Given the high prevalence of HHV-8,--the so-called K.S. herpes virus--in Sardinia (Reference) is it at all possible that HHV-8 may have been misclassified and actually is a human-adapted form of African Swine Fever Virus? (ASFV has been at least visually mistaken for another herpes virus, CMV, in the past.)

A number of experiments could be conducted to explore this hypothesis. In addition to a direct comparison of ASFV and HHV-8, pigs with African Swine Fever Virus could be tested for sequences of HHV-8. People with Kaposi's sarcoma could be tested for sequences of African Swine Fever, including new Asfaviridae sequences recently discovered. (Reference) 

A comparison of the K.S. lesions in humans and ASFV lesions in pigs might be in order.Given that African Swine Fever is currently spreading in Russia and is now threatening Europe and China, (Reference) it would be useful to know whether people who are exposed to pigs with ASFV are at increased risk for HHV-8, Kaposi's sarcoma and the other pathologies associated with HHV-8. A study in sub-Saharan Africa where ASFV is endemic and HHV-8 is also endemic (Reference) might be useful. And areas of Russia where ASFV is spreading could be monitored closely for any signs of an increase of K.S. or HHV-8 infection and HHV-8 related pathologies.HHV-8 is an emerging health problem. HHV-8-associated K.S. is a significant problem in AIDS patients. It may also be the key to Chronic Fatigue Syndrome. HHV-8 has been found in the cerebrospinal fluid of 50% of Chronic Fatigue Syndrome patients. (Reference) HHV-8 has been linked to type 2 diabetes. (Reference) HHV-8 has been detected in B-cells in Castleman's disease and primary effusion lymphoma. (Reference).

If HHV-8 is a form of ASFV, it is possible that pigs might constitute a useful animal model for the study of possible treatments for K.S. and other pathologies associated with HHV-8. And if there is any relationship between ASFV and HHV-8, people may have to be warned to take special precautions around pigs in areas where there are ASFV outbreaks. And countries where undercooked pork is consumed (like Ukraine where salo is a staple) may need to alert the public to cook all pork products thoroughly during ASFV epidemics.

7. ASF virus, adapted to grow in VERO cells, produces a strong cytopathic effect in human macrophages leading to cell destruction.

8. A sick child tests positive for African Swine Fever virus.

9. Newspaper publisher writes The Chronic Fatigue Syndrome Epidemic Cover-up, a memoir about uncovering the African Swine Fever cover-up in America.

The Chronic Fatigue Syndrome Epidemic Cover-up details the investigative reporting of a New York Native that reveals the Centers for Disease Control and the United States Department of Agriculture lied about the presence of African Swine Fever in pigs and people.

10. Journalist pens The African Swine Fever Novel, an Orwellian novel warning about the consequences of an African Swine Fever Virus epidemic in humans.

The African Swine Fever Novel is available here

11. Prisoners fed meat infected with African Swine Fever

The day Anthony Fauci told journalists they could lose their access to scientists.

The AAAS Observer, September 1989

From the September 1, 1989 AAAS Observer

Writing for My Sister Denise

    AIDS has created a whole new interaction between scientists and the press. When I first got involved in AIDS research, I was reluctant to deal with the press. I thought it was not dignified. But there was a lot of distortion by people who were speaking to the press, so I changed my mind.

     What is the media’s responsibility in recording science? My interpretation frequently does not jibe with what even competent journalists think. Is it to report what is important, or what is newsworthy? Sometimes those two are not the same.

     One crucial area of AIDS research is our attempts to understand the regulatory genes of HIV. It is magnificent science, and it is not only going to tell us things about HIV, but also how the cell is controlled by viral genes and how the virus is controlled by cellular genes. Yet rarely does it get coverage. By contrast, everyone knows about compound Q, the Chinese root that is supposed to “cure” AIDS. I have been asked far more often about compound Q than about work on determining the pathogenic mechanisms of HIV infection.

     Scientists tend to lump all the media together. But just as there is a spectrum of scientists, there is a spectrum of publications, networks, and radio stations. Scientists regard Science as the gold standard.  But there are also major newspapers like the Washington Post, and the New York Times, which have experienced science staffs. The next level is the news magazines, which usually are quite accurate but rely a bit more on sensationalism. And then there are other publications that are incompetent, or care only about sales, or have axes to grind.

     The media are no place for amateurs, particularly when talking about a public health problem of the magnitude of AIDS. I remember the sinking feeling I got when a writer asked me how to spell “retrovirus”. Someone who does not know that has not read anything significant on AIDS, and should automatically be disqualified from doing an AIDS story.

     There is also heterogeneity among television shows. It is disconcerting when interviewers ask you questions, and you look into their eyes, and it is very clear they are not listening to the answers. But there are some real pros—for example, those on the McNeil-Lehrer show and David Brinkley’s.

     The media are great equalizers in science, which is most disturbing to us scientists. Any scientist questioned in the media becomes an “expert.” We know reporters must consult more than one source and make room for dissenting opinions. But many people consider what is in the media to be true by definition.

     One striking example is Peter Duesberg’s theory that HIV is not the cause of AIDS. I laughed at that for a while, but it led to a lot of public concern that maybe HIV was a hoax. The theory has enormous credibility just on the basis of news coverage.

     My barometer of what the general public is really thinking is my sister Denise. My sister Denise is an intelligent woman who reads avidly, listens to the radio, and watches television, but she is not a scientist. When she calls me and questions my integrity as a scientist, there really is a problem. Denise has called me at least ten times about Peter Duesberg. She says, “Anthony”—she is the only one who calls me Anthony—“are you sure he’s wrong?” That’s the power of putting someone on television or in the press, although there is virtually nothing in his argument that makes scientific sense.

     People are especially concerned when they see divergent reports about the same thing. They do not understand that the beauty of science is that it is intrinsically self-corroborating and self-correcting, that it is important for scientists to be wrong. The lack of clear-cut black-or-white answers plagues the biomedical scientists compared with the physical sciences. Stanley Pons and Martin Fleishmann said they achieved nuclear fusion at room temperature. Other scientists tried, but could not reproduce it. Bingo, it’s over. But because we cannot ethically do clinical trials to establish that he is wrong, I am probably going to be answering Peter Duesberg for the rest of my life.

     Scientists need to get more sophisticated about expressing themselves. But the media have to do their homework. They have got to learn the issues and the background. And they should realize that their accuracy is noted by the scientific community. Journalists who have made too many mistakes, or who are sloppy, are going to find that their access to scientists may diminish.

Monday, June 29, 2020

A brief excerpt from the Chronic Fatigue Syndrome epidemic publishng event of the year.

Remdesivir is beginning to look like one of the biggest scams in the history of science and medicine

Saturday, June 27, 2020

Is HHV-6 a major issue in Covid-19 ICU patients?

Intensive care (ICU) patients with co-infections of HHV-6 and CMV are 7.5x more likely to die or have an extended stay in the hospital (95% confidence interval, 1.9-29.9), according to investigators at the University of Washington who studied viremia in 115 acutely ill adults,who%20studied%20viremia%20in%20115%20acutely%20ill%20adults.

Reactivation of human beta-herpesviruses (cytomegalovirus [CMV], human herpesvirus [HHV]-6, and HHV-7) in nonimmunocompromised hosts is rare. Because these viruses are susceptible to reactivation by cytokines and stress-related mechanisms, the incidence of their reactivation was investigated among 120 patients during stress related to critical illness and compared with findings among 50 healthy volunteers. Human beta-herpesvirus DNA was found in 65% of critically ill patients (60% men; mean age, 63 years) who required admission to an intensive care unit for medical (40%) or surgical (53%) indications or trauma (7%). HHV-6 reactivation was higher in critically ill patients than in healthy volunteers (54/101 vs. 0/50; P=.001). All patients except 1 were confirmed as HHV-6 variant A (mean virus load, 5066 copies/10(6) peripheral blood leukocytes). The reactivation of HHV-6A did not affect disease severity and outcome. No significant reactivation of HHV-7 or CMV was demonstrated among the critically ill pa

Learn more about the HHV-6 cover-up that has been going  on for four decades behind the façade of Antony Fauci's HIV Ponzi scheme.

Friday, June 26, 2020

Is HHV-6 driving Covid-19 morbidity and mortality? Will Covid-19 bring the HHV-6 and Chronic Fatigue Syndrome pandemic out of the closet?

Positive detection of SARS‐CoV‐2 combined HSV1 and HHV6B virus nucleic acid in tear and conjunctival secretions of a non‐conjunctivitis COVID‐19 patient with obstruction of common lacrimal duct

Want to know more about HHV-6? Check out this book:

Thursday, June 25, 2020

The latest on the Lancetgate scandal

Tuesday, June 16, 2020

Are we one step closer to recognizing HHV-6 is a public health crisis?


Scientists discover ‘fatigue’ protein that raises hope of blood test to diagnose depression 

"Prof. Kondo’s team was able to confirm that the human herpes virus type 6, or HHV6, increases sharply in a person’s saliva when fatigue and stress build up. Virtually everyone is infected with the virus during infancy and it typically remains dormant in the body. When a person becomes tired, however, HHV6 can become active again and can be detected in saliva. Some of the virus also travels to the olfactory bulb, the part of the brain that is connected to the sense of smell. Should the olfactory bulb become infected, it produces SITH1 proteins – which Prof. Kondo first identified a decade ago and jokingly named after the Dark Lord of the Sith in the Star Wars series of films because it “takes people to the dark side”, he said. The proteins produce excessive amounts of calcium, which then flow into brain cells and kill them. The death of cells also reduces the regeneration of nerves in the hippocampus, which controls human memory. Over time, the protein impacts a person’s ability to make decisions, induces lethargy and other symptoms linked to depression."


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