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Tuesday, July 15, 2014

HHV-6 and Cancer: No Surprise Here

What is the Second Leading Cause of Cancer; The CBCD Reviews Surprising Data

“Epidemiological data imply that viruses are the second most important risk factor for cancer,” according to a study published on June 6, 2014 in the Journal of Neurology, Neurosurgery, and Psychiatry (1). The Center for the Biology of Chronic Disease (CBCD) reviews the medical literature and explains the relationship between cancer and Dr. Hanan Polansky’s discovery.

Rochester, NY (PRWEB) June 20, 2014
Science may be finally catching up to the ground breaking ideas presented in Dr. Hanan Polansky’s book, “Microcompetition with Foreign DNA and the Origin of Chronic Disease,” which was published more than 10 years ago. Doctor Dey and his team of researchers suggest that “Epidemiological data imply that viruses are the second most important risk factor for cancer (1).” Yet, Dr. Polansky’s work in 2003 identified latent viruses as the “origin of many chronic diseases, such as cancer, atherosclerosis, stroke, obesity, diabetes, multiple sclerosis, lupus, thyroiditis, osteoarthritis, rheumatoid arthritis, and alopecia.” (See Microcompetition with Foreign DNA and the Origin of Chronic Disease, published in 2003) (2) Specifically, Dr. Polansky’s work explains how foreign DNA fragments, created by latent viruses, can cause these, and many other major diseases. The book has been read by more than 5,000 scientists around the world, and has been reviewed in more than 20 leading scientific journals.
Dr. Dey and his colleagues further wrote that “Although the ability of certain viruses (hepatitis B and C, human papillomavirus, etc) to cause cancer has been time tested and proven scientifically, there are several other potential viral candidates whose role in oncogenesis (development of cancer) is more controversial (1).” These candidates are listed in Dr. Polansky’s book. They include the herpesvirus family of viruses (HSV-1, HSV-2, EBV, CMV, VZV, HHV-6, HHV-7 etc.), and the Human Immunodeficiency Virus (HIV) (2). Dr. Polansky’s book also explains why these viruses, and not others, cause cancer.
Dr. Polansky’s theory, discusses how these latent viruses that include foreign DNA fragments called N-boxes, are causing most major diseases. For example, “The theory describes the effect of Foreign DNA fragments that include the cis-regulatory element, called an N-box, on transcription of cellular genes. Consider foreign N-boxes that entered the body naturally, through, for instance, an infection or digestion, or artificially, through, for instance, an injection of some treatment. The foreign N-boxes attract the transcription complex GABP∙p300. Since the complex is a scarce genetic resource, the foreign N-boxes decrease the availability of this complex to cellular genes.” (2)
What is the result of Microcompetition?
The genes that are transactivated by the GABP∙p300 complex produce fewer proteins, and the genes that are suppressed by this complex produce more proteins. The abnormal levels of these cellular proteins cause a disease. It is interesting that many common viruses that establish a latent infection have strong N-boxes in their promoter/enhancer. They include the Epstein-Barr virus (EBV), Cytomegalovirus (CMV), Herpes Simplex virus (HSV), Varicella Zoster virus (VZV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and the Human Papillomavirus (HPV). In fact, the CMV has the strongest promoter/enhancer known to science. Liu et al. showed that the CMV promoter/enhancer, which includes the N-box, is more than 150-fold stronger than the promoter of the platelet-derived growth factor-b chain (PDGF-b) gene.” (See Pharmacology & Pharmacy, from March 2014) (3). The Microcompetition theory predicts that a latent infection with CMV will cause a decrease in PDGF-b transcription, a decrease in the concentration of the PDGF-b protein, and disease.

Pathogenesis From the Reactivation of Chromosomally Integrated Human Herpesvirus Type 6: Facts Rather Than Fiction.

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