Is HHV-6 a major issue in Covid-19 ICU patients?





Intensive care (ICU) patients with co-infections of HHV-6 and CMV are 7.5x more likely to die or have an extended stay in the hospital (95% confidence interval, 1.9-29.9), according to investigators at the University of Washington who studied viremia in 115 acutely ill adults 

https://hhv-6foundation.org/transplant-complications/icu-patients-with-hhv-6-cmv-co-reactivation-have-poor-outcome#:~:text=Intensive%20care%20%28ICU%29%20patients%20with%20co-infections%20of%20HHV-6,who%20studied%20viremia%20in%20115%20acutely%20ill%20adults.

Reactivation of human beta-herpesviruses (cytomegalovirus [CMV], human herpesvirus [HHV]-6, and HHV-7) in nonimmunocompromised hosts is rare. Because these viruses are susceptible to reactivation by cytokines and stress-related mechanisms, the incidence of their reactivation was investigated among 120 patients during stress related to critical illness and compared with findings among 50 healthy volunteers. Human beta-herpesvirus DNA was found in 65% of critically ill patients (60% men; mean age, 63 years) who required admission to an intensive care unit for medical (40%) or surgical (53%) indications or trauma (7%). HHV-6 reactivation was higher in critically ill patients than in healthy volunteers (54/101 vs. 0/50; P=.001). All patients except 1 were confirmed as HHV-6 variant A (mean virus load, 5066 copies/10(6) peripheral blood leukocytes). The reactivation of HHV-6A did not affect disease severity and outcome. No significant reactivation of HHV-7 or CMV was demonstrated among the critically ill pa


https://pubmed.ncbi.nlm.nih.gov/11756989/


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