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Friday, April 10, 2015

Is it possible that human infections of African Swine Fever Virus will be the first sign that the disease has hit Western Europe?

"Since antibodies for the African Swine virus have been detected in humans, the possibility of human infection with the African Swine virus exists and may thus far have escaped any systematic screening. Thus, any preventive and therapeutic approach to African Swine fever can have far-reaching implications to control immune deficiency conditions in humans."

Read more: http://www.faqs.org/patents/app/20080207875#ixzz3Wwwc8X9T


"While the African Swine virus has been primarily detected in pigs and certain other animals, antibodies against the African Swine virus have also been found in humans (5). The fact that there was no description of any finding of the African Swine virus in humans may thus be attributable to oversight or a lack of understanding for the significance of African Swine fever virus for the pathogenicity of immune deficiencies in humans."

Read more: http://www.faqs.org/patents/app/20080207875#ixzz3Wx2bA15H

African Swine Fever Virus (Asfarviridae) sequences found in people with febrile illnesses

Abstract
Virus Identification in Unknown Tropical Febrile Illness Cases Using Deep Sequencing
Dengue virus is an emerging infectious agent that infects an estimated 50–100 million people annually worldwide, yet current diagnostic practices cannot detect an etiologic pathogen in ∼40% of dengue-like illnesses. Metagenomic approaches to pathogen detection, such as viral microarrays and deep sequencing, are promising tools to address emerging and non-diagnosable disease challenges. In this study, we used the Virochip microarray and deep sequencing to characterize the spectrum of viruses present in human sera from 123 Nicaraguan patients presenting with dengue-like symptoms but testing negative for dengue virus. We utilized a barcoding strategy to simultaneously deep sequence multiple serum specimens, generating on average over 1 million reads per sample. We then implemented a stepwise bioinformatic filtering pipeline to remove the majority of human and low-quality sequences to improve the speed and accuracy of subsequent unbiased database searches. By deep sequencing, we were able to detect virus sequence in 37% (45/123) of previously negative cases. These included 13 cases with Human Herpesvirus 6 sequences. Other samples contained sequences with similarity to sequences from viruses in the Herpesviridae, Flaviviridae, Circoviridae, Anelloviridae, Asfarviridae, and Parvoviridae families. In some cases, the putative viral sequences were virtually identical to known viruses, and in others they diverged, suggesting that they may derive from novel viruses. These results demonstrate the utility of unbiased metagenomic approaches in the detection of known and divergent viruses in the study of tropical febrile illness.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274504/

"Ablashi asserts that HHV-6A is the predominant strain in CFS, multiple sclerosis (MS) and AIDS patients.."


"In vitro tests indicate HHV-6 can infect many different cell types including dendritic cells, NK cells and fibroblasts as well as liver, epithelial and endothelial cells and the glial cells in the brain (astrocytes, oligodendrocytes, microglia). The HHV6 genome has been detected in brain, liver, skin, lungs, kidneys, heart, tonsils, salivary glands, esophagus, etc. It is believed to make its way to the brain on board T lymphocytes able to penetrate the blood:brain barrier.
Although HHV-6 is able to infect many cells, in only a few is it able to progress to the ‘lytic phase’. (The lytic phase occurs when a virus enters the cells and uses its DNA to produce virions which usually end up killing the cell, allowing them to escape en masse.) HHV-6 can replicate in B cells and NK cells but productive HHV-6 infection is believed to be confined to T lymphocytes, in particular in T-helper (CD4+) cells, monocytes/macrophages, neurons, astrocytes and oligodendrocytes (Kakimoto et al. 2002, Grivel et al. 2003, Fotheringham et al. 2008)).




http://phoenixrising.me/research-2/the-pathogens-in-chronic-fatigue-syndrome-mecfs/hhv-6-and-chronic-fatigue-syndrome-mecfs-an-overview/human-herpes-virus-6-hhv-6-and-disease

Fauci's new department . . .

rachel maddow, tony fauci, cfs, aids, hhv-6, autism, chronic fatigue syndrome

HHV-6 New York Native Flashback #11

The Centers for Disease Control (CDC) has been criticized, by journalists, health activists, and members of Congress, for the almost imperceptible progress it has made in developing programs to define the parameters of the ongoing epidemic of Chronic Immune Dysfunction Syndrome (CIDS) . An editorial in the January/February issue of the CFIDS Chronicle cites two devastating remarks downplaying the importance of the illness by CDC's Dr. Gary Holmes, who is in charge of the CDC's CIDS efforts: Holmes has labeled CIDS a "wastebasket disease," and stated in an April 1988 Health article, "A number of heads of departments of infectious disease at major universities think this is a disease of neurotic women."
   --Neenyah Ostrom, New York Native, May 15, 1989

The Big Question for Russian and European Scientists.

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How to Become an HHV-6 Activist.

http://hhv6.blogspot.com/p/visit-hhv-6-store.html

The Big Question for Hillary Clinton.

hillary clinton, hhv-6, activism,


A Neonate with Acute Heart Failure: Chromosomally Integrated Human Herpesvirus 6–Associated Dilated Cardiomyopathy

http://www.jpeds.com/article/S0022-3476%2815%2900248-6/abstract

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