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Wednesday, February 22, 2017

Dr. Podell on HHV-6

"Dr. Jose Montoya, a chronic fatigue syndrome physician at Stanford Medical School, treated 25 chronic fatigue syndrome (CFS) patients with Valcyte, an oral medicine that blocks HHV-6, Epstein Barr virus and other Herpes family viruses. Spectacularly, 21 of 25 patients dramatically improved. Most achieved near resolution of their CFS symptoms after a six month course of treatment. This allowed return to work or other full-time activities. Of those whose CFS had begun with a flu-like illness, 20 out of 21 gained improved health."

http://www.drpodell.org/chronic-fatigue-syndrome-hhv6.shtml

Want to know the whole truth about Chronic Fatigue Syndrome? Start reading Truth to Power right here.

One of the Biggest Myths About Chronic Fatigue Syndrome Just Got Debunked

http://www.sciencealert.com/one-of-the-biggest-myths-about-chronic-fatigue-syndrome-just-got-destroyed

Does problem with intracellular calcium strengthen case that CFS is AIDS-related????

Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients


Conclusions

Our novel discovery of TRPM3 on NK and B lymphocytes and their significantly reduced expression in CFS/ME patients, together with the preliminary discovery of impaired Ca2+ cytoplasmic concentration in these cells, suggests impaired Ca2+ metabolism may be implicated as a novel pathway for pathogenesis of CFS/ME. Further investigation may elucidate intracellular Ca2+ signalling pathways and the potential role this may play on transcriptional factors, such as NFκB and NFAT as both are activated by calcium through the calmodulin dependent protein kinases and phosphatases. Moreover, as TRPs are widely expressed on almost all human cells and tissues, this raises the question as to whether similar changes of TRPM3 expression or function of these receptors promotes more widespread disruption of intracellular signalling homeostasis in CFS/ME patients.

https://biolres.biomedcentral.com/articles/10.1186/s40659-016-0087-2


Changes in Blood Cell Membrane Properties in HIV Type1Infected Patients


Abstract
To evaluate the possible HIV-1 infection-induced changes in cell membrane properties and in calcium signaling, membrane fluidity, acetylcholinesterase (AChE, a glycosylphosphatidylinositol-anchored protein) activity, and intracellular calcium concentration ([Ca2(+)](int)) were evaluated in lymphocytes and erythrocytes of infected individuals, previous to their engagement in antiretroviral therapy. Membrane fluidity was assessed by fluorescence spectroscopy measurements, using the fluorescence probes 1,6-diphenyl-1,3,5-hexatriene (DPH) and 1-[4-(trimethylamino)-phenyl]-6-phenyl-1,3,5-hexatriene (TMA-DPH). AChE activity was determined by the colorimetric Ellman's method and [Ca2(+)](int) using the fluorescent fura-2 acetoxymethyl ester. When compared with the control group, lymphocytes of infected patients presented significantly decreased membrane fluidity, decreased AChE activity, and increased [Ca2(+)](int). Erythrocytes from HIV-infected patients presented decreased [Ca2(+)](int) when compared with the control group and decreased membrane fluidity near the lipid/water interface. Our data show that HIV-1 infection leads to biochemical and biophysical changes in the membrane itself and in membrane protein activity in lymphocytes (average of infected and noninfected subpopulations) and even in erythrocytes. The present observations are in agreement with a process of facilitated propagation of the infection to new cells, stimulation of virion production, and maintenance of a reservoir of erythrocyte-bound infectious virus.


A major turning point in CFS research.

One of the Biggest Myths About Chronic Fatigue Syndrome Just Got Debunked.


Breaking News

Is it HHV-6 and does this research link CFS to AIDS?


http://statements.qld.gov.au/Statement/2017/2/21/gold-coast-researchers-make-chronic-fatigue-breakthrough

Minister for Innovation, Science and the Digital Economy and Minister for Small Business
The Honourable Leeanne Enoch

Tuesday, February 21, 2017

Gold Coast researchers make chronic fatigue breakthrough

In a world first, Gold Coast researchers have made an important breakthrough in understanding the cause of Chronic Fatigue Syndrome.
Science Minister Leeanne Enoch said researchers from Griffith University’s National Centre for Neuroimmunology and Emerging Diseases (NCNED) have found strong evidence that chronic fatigue syndrome was associated with a dysfunctional immune system.
“The research team, led by Professor Sonya Marshall-Gradisnik and Professor Don Staines, have identified a dysfunctional cell receptor in the immune system which seems to be at the core of the problem,” Ms Enoch said.
“This discovery is great news for all people living with Chronic Fatigue Syndrome (CFS) and the related Myalgic Encephalomyelitis (ME), as it confirms what people with these conditions have long known - that it is a ‘real’ illness - not a psychological issue.
“CFS and ME are notoriously difficult to diagnose, with sufferers often going for years without getting the proper care and attention they need. Currently, there is no effective treatment.
“The Griffith University breakthrough now means we have a target for therapeutic intervention, which is welcome news to the 250,000 Australians believed to be affected by CFS and ME.”
Health Minister Cameron Dick praised researchers for working hard to help people suffering from CFS and ME.
“According to ME/CFS Australia, the cost to the Australian community of CFS/ME diagnosis, treatment and management is estimated to reach more than $700 million annually,” Mr Dick said.
“But that is nothing compared to the devastating impact the conditions have on sufferers, along with their families and friends.
“I am thrilled that funding from our Government is playing a hand in changing people’s lives for the better.”
Professor Marshall-Gradisnik said Queensland Government funding had been critical in progressing the research.
“The Queensland Government has funded NCNED continuously since 2008, totalling about $1.6 million all up, enabling the research centre to be a world leader in chronic fatigue research. This is the largest direct contribution of any government anywhere in the world to chronic fatigue syndrome research,” Professor Marshall-Gradisnik said.
“It clearly demonstrates what can be achieved with critical government funding.”
The NCNED also received a $4 million grant from the Stafford Fox Medical Research Foundation – the largest grant ever provided for CFS/ME research.
Professor Don Staines said this funding would be used to investigate the commercialisation of a diagnostic test the research team were developing as well as potential treatments.
“This is a huge boost to our research effort, enabling us to really look at how we can overcome this debilitating illness,” Professor Staines said.
Griffith Vice Chancellor Professor Ian O’Connor welcomed the ongoing support from the Queensland Government.
“The most effective research is now coming more often from powerful collaborations such as this,” Professor O’Connor said.


Want to know the whole truth about Chronic Fatigue Syndrome? Start reading Truth to Power right here.

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