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Tuesday, October 03, 2017

Will pig models help determine if HHV-6 is the cause of autism?

"Traditional biomedical models are easy to manage in experimental facilities and allow fast and affordable basic genetic studies related to human disorders, but in some cases they do not always represent the complexity of their physiology. Translational medicine demands selected models depending on the particularities of the human disease to be investigated, reproducing as closely as possible the evolution, clinical symptoms and molecular pathways, cells or tissues involved in the dysfunction. Thus, pig models offer an alternative because of their anatomical and physiological similarities to humans and the availability of genomic, transcriptomic and, progressively more, proteomic tools for analysis of this species. Furthermore, there is a wide range of natural, selected and transgenic porcine breeds. The present review provides a summary of the applications of the pig as a model for metabolic, cardiovascular, infectious diseases, xenotransplantation and neurological disorders and an overview of the possibilities that the diverse proteomic techniques offer to study these pathologies in depth."

More connections between AIDS and Chronic Fatigue Syndrome?

"The current study showed alterations in both grey matter and white matter volume in patients with Chronic Fatigue Syndrome. Some of those findings, particularly those in GM, are novel and may indicate altered processing of interoceptive signals in CFS patients. Future studies should incorporate measures of interoceptive processing to more directly interrogate this potential link to CFS. The differences in WM volume were seen in areas that have previously shown abnormalities in CFS albeit partially of a different kind. The current findings suggest abnormalities in a network of insular-limbic regions, as well as changes to WM tracts of the midbrain, brainstem and temporal cortex."

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