Three Big Books

Sunday, January 14, 2018

Combined Antiretroviral Therapy Causes Cardiomyopathy and Elevates Plasma Lactate in Transgenic AIDS Mice

The truth About HHV-8 in Castleman Disease may force the CDC to tell the truth about HHV-8 in AIDS.

If HHV-8 (which seems to cause Castleman Disease) really is African Swine Fever then pigs will make an excellent model for studying Castleman Disease. Is this an indication that HHV-8 is really African Swine Fever Virus?

"Primary HHV-8 infection may be associated with fever and a maculopapular rash in immunocompetent children."

High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia.

Infection with human herpesvirus type 8 and Kaposi's sarcoma in Sardinia.


 Epidemiology of HHV8 in Sardinian emigrants

 Both ASFV and HHV-8 Interfere with apoptosis.

Are ASFV-infected Pigs the viral source of HHV-8 related Kaposi's Sarcoma in Sardinia? Is a ASFV-related Kaposi's Sarcoma epidemic possible in Russia where ASFV is spreading?

The world's highest incidence of Kaposi's sarcoma occurs in Sardinia (Reference) Is it possible that it is due to the fact that African Swine Fever Virus is endemic on the island? (Reference) One study suggests that the incidence of K.S. in northern Sardinia is highest in a countryside area where people have contact with animals. (Reference) Given the high prevalence of HHV-8,--the so-called K.S. herpes virus--in Sardinia (Reference) is it at all possible that HHV-8 may have been misclassified and actually is a human-adapted form of African Swine Fever Virus? (ASFV has been at least visually mistaken for another herpes virus, CMV, in the past.)

A number of experiments could be conducted to explore this hypothesis. In addition to a direct comparison of ASFV and HHV-8, pigs with African Swine Fever Virus could be tested for sequences of HHV-8. People with Kaposi's sarcoma could be tested for sequences of African Swine Fever, including new Asfaviridae sequences recently discovered. (Reference) 

A comparison of the K.S. lesions in humans and ASFV lesions in pigs might be in order.Given that African Swine Fever is currently spreading in Russia and is now threatening Europe and China, (Reference) it would be useful to know whether people who are exposed to pigs with ASFV are at increased risk for HHV-8, Kaposi's sarcoma and the other pathologies associated with HHV-8. A study in sub-Saharan Africa where ASFV is endemic and HHV-8 is also endemic (Reference) might be useful. And areas of Russia where ASFV is spreading could be monitored closely for any signs of an increase of K.S. or HHV-8 infection and HHV-8 related pathologies.HHV-8 is an emerging health problem. HHV-8-associated K.S. is a significant problem in AIDS patients. It may also be the key to Chronic Fatigue Syndrome. HHV-8 has been found in the cerebrospinal fluid of 50% of Chronic Fatigue Syndrome patients. (Reference) HHV-8 has been linked to type 2 diabetes. (Reference) HHV-8 has been detected in B-cells in Castleman's disease and primary effusion lymphoma. (Reference).

If HHV-8 is a form of ASFV, it is possible that pigs might constitute a useful animal model for the study of possible treatments for K.S. and other pathologies associated with HHV-8. And if there is any relationship between ASFV and HHV-8, people may have to be warned to take special precautions around pigs in areas where there are ASFV outbreaks. And countries where undercooked pork is consumed (like Ukraine where salo is a staple) may need to alert the public to cook all pork products thoroughly during ASFV epidemics.


A number of years ago, Neenyah Ostrom reported in the New
York Native on the lesions in CFS patients which seem
to resemble Kaposi's Sarcoma (KS). The current
thinking is that a virus called HHV-8 is the cause of
KS. (Although HHV-6 has recently also been implicated
once again.) If KS is a problem in CFS (and we
suspect it is) then one should be able to find HHV-8 and
HHV-6 in CFS patients. Apparently, in this small
study, one can. Below is a rather explosive abstract:
Prevalence in the cerebrospinal fluid of the following
infectious agents in a cohort of 12 CFS subjects:
human herpes virus-6 and 8; chlamydia species;
mycoplasma species; EBV; CMV; and Coxsackievirus.
Levine, S.
Journal of Chronic Fatigue Syndrome, 2001, 9, 1/2,
Over the last decade a wide variety of infectious
agents have been associated with the CFS as potential
etiologies for this disorder. Many of these agents are
neurotrophic and have been linked previously to other
diseases involving the central nervous system (CNS).
Human herpes virus-6 (HHV-6), especially the B
variant, has been found in autopsy specimens of
patients who suffered from MS. Because patients with
CFS manifest a wide range of symptoms involving the
CNS as shown by abnormalities on brain MRIs, SPECT
scans of the brain and results of tilt table testing
we sought to determine the prevalence of HHV-6, HHV-8,
Epstein-Barr Virus (EBV), cytomegalovirus (CMV),
mycoplasma species, chlamydia species, and Coxsackie
virus in the spinal fluid of a group of 12 patients
with CFS (CDC criteria '94).
We found evidence of HHV-6, HHV-8, chlamydia species,
CMV and Coxsackie virus in 6/12 samples. Plasma tests
were negative. It was surprising to obtain such a
relatively high yield of infectious agents in cell
free specimens of spinal fluid that had not been
centrifuged. Future research in spinal fluid analysis,
in addition to testing tissue samples by polymerase
chain reaction (PCR) and other direct viral isolation
techniques will be important in characterizing
subpopulations of CFS patients, especially those with
involvement of the CNS.
The low rate of isolation of HHV-6 may be related to
the lack of gross neurological findings in the
patients at the time of testing.
An overview of KS:
Except for those who have made a lifelong commitment
to denial, finding the so-called "KS virus" (HHV-8)
and the "supporting KS virus" (HHV-6) in CFIDS patients
should help settle the question of the overlapping
nature of the AIDS and CFIDS epidemics.
Isn't it time to take a closer look at those crimson
crescents in the throats of CFIDS patients?
More info on KS here.

Given that HHV-8 is part of the HHV-6 and HHV-7 family, this may be very important:

"The 19R Protein of HHV-6 has significant amino acid sequence homology . . . to a protein encoded by African Swine Fever Virus."

--Glenda L. Lawrence, John Nicholas and Bart G. Barrell
Journal of General virology (1995), 76, 147-152

 Click here for more information on this issue.

  animal model, asfv, cdc, HHV-6, hhv-7, HHV-8, pigs, PLHV, porcine herpesvirus, swine



The Chronic Fatigue Syndrome and HHV-6 Cover-up in the Gay Community

The best article about Chronic Fatigue Syndrome and the HHV-6 cover-up in the gay community.

"Together Alone" by Michael Hobbes, published in Huffington Post (which just loves calling gays "queers") purports to be about the epidemic of gay loneliness. But the news it really breaks is that there is an epidemic of illness in the gay community that in most likelihood is related to the HHV-6 and AIDS/Chronic Fatigue Syndrome cover-up in the gay community. 

The passage that seems to bring the real epidemic of HHV-6, Chronic Fatigue Syndrome, non-HIV AIDS (or whatever you want to call it) is this one.

     Travis Salway, a researcher with the BC Centre for Disease Control in Vancouver, has spent the last five years trying to figure out why gay men keep killing themselves.
“The defining feature of gay men used to be the loneliness of the closet,” he says. “But now you’ve got millions of gay men who have come out of the closet and they still feel the same isolation.”
We’re having lunch at a hole-in-the-wall noodle bar. It’s November, and he arrives wearing jeans, galoshes and a wedding ring.
     “Gay-married, huh?” I say.
     “Monogamous even,” he says. “I think they’re gonna give us the key to the city.”
     Salway grew up in Celina, Ohio, a rusting factory town of maybe 10,000 people, the kind of place, he says, where marriage competed with college for the 21-year-olds. He got bullied for being gay before he even knew he was. “I was effeminate and I was in choir,” he says. “That was enough.” So he got careful. He had a girlfriend through most of high school, and tried to avoid boys—both romantically and platonically—until he could get out of there.
     By the late 2000s, he was a social worker and epidemiologist and, like me, was struck by the growing distance between his straight and gay friends. He started to wonder if the story he had always heard about gay men and mental health was incomplete.
When the disparity first came to light in the ’50s and ’60s, doctors thought it was a symptom of homosexuality itself, just one of many manifestations of what was, at the time, known as “sexual inversion.” As the gay rights movement gained steam, though, homosexuality disappeared from the DSM and the explanation shifted to trauma. Gay men were being kicked out of their own families, their love lives were illegal. Of course they had alarming rates of suicide and depression. “That was the idea I had, too,” Salway says, “that gay suicide was a product of a bygone era, or it was concentrated among adolescents who didn’t see any other way out.”
     And then he looked at the data. The problem wasn’t just suicide, it wasn’t just afflicting teenagers and it wasn’t just happening in areas stained by homophobia. He found that gay men everywhere, at every age, have higher rates of cardiovascular disease, cancer, incontinence, erectile dysfunction,⁠ allergies and asthma—you name it, we got it.

When we read this last paragraph to Dr. Michael Goldberg, the researcher who has connected Chronic Fatigue Syndrome to autism, he just laughed dismissively. Any doctor who thinks that list of ailments is caused by "gay loneliness" should lose their license. That Hobbes doesn't realize what he is saying kind of characterizes the "queer" state of journalism at Huffington Post. But we are grateful to Mr. Hobbes because he has probably simultaneously undermined the fraudulent HIV theory of AIDS and answered the question about HHV-6 and the Chronic Fatigue Syndrome form of AIDS in the gay community which was posed in this previous piece that we published:

Where is the Massive Gay Chronic Fatigue Syndrome Epidemic?

While AIDS has dominated the medical news for the last two decades, another potentially major epidemic which the media has generally ignored or minimized, has grown exponentially. Originally mocked as "Yuppie Flu," the name "Chronic Fatigue Syndrome (CFS)" eventually evolved into what is now known as "Chronic Fatigue and Immune Dysfunction Sydrome (CFIDS)." The Centers for Disease Control and the National Institutes of Health (for very mysterious reasons) have been slow to respond to the potentially catastrophic epidemic of CFIDS which began to manifest itself at the same time as AIDS. Given that there have been many reports of CFIDS breaking out in families, schools, and communities, there is little doubt among serious observers that it is contagious. If this is so, why is it not spreading like wildfire in the gay community? What biological wall around the gay community has prevented CFIDS from being a major gay health problem?

Neenyah Ostrom, who reported on CFIDS for a decade at "New York Native," has written three books giving a detailed history of the research on CFIDS. She has reported on a long list of symptoms and immune aberrations have been found in Chronic Fatigue Syndrome; virtually all of them can also be found in AIDS patients. These include problems with T-cells, natural killer cells, B-cells, and monocytes. There are serious neurological, digestive and cardiac symptoms that AIDS and CFIDS share. Where are all the gay men with the often serious CFIDS problems? Do they have some special immunological protection against CFIDS? Or is it that every gay person who has AIDS also has CFIDS? How does that work? How do doctors treat CFIDS in an AIDS patient? How come we never read anything about that?

The medical literature is full of suggestions that, at the very least, CFIDS is AIDS-like. Some research suggests that an even stronger statement about its relationship to AIDS could be made. Nancy Klimas, one of the pioneering CFS researchers, led a team of scientists who concluded in 1990 that Chronic Fatigue Syndrome could be considered "a form of acquired immunodeficiency." Paul Cheney, one of the first medical doctors to look closely at the epidemic of CFS, has referred to it as "AIDS minor." Others have somewhat bizarrely called it an epidemic of something that could be called the "mirror-image of AIDS." Well, what about the gay community? Where is the epidemic of the "mirror image of AIDS" in the AIDS-besieged gay community? What is the difference between a gay person with AIDS and a gay person with "the mirror-image of AIDS." I bet that virtually no members of the gay community are aware that there could be thousands of members of their community with the contagious "mirror image of AIDS."

Saying that CFIDS is not a fatal condition and doesn't deserve any serious attention is not really a fact-based statement. A number of people with CFIDS do seem to have died of complications of their conditions. A Massachusetts-based organization for CFIDS patients has a page of obituaries in every issue of their newsletter and many of the deceased people they report on seem to have died from problems related to their CFIDS. When was the last time you heard of a gay person dying of complications of CFIDS? And even though it may not always be fatal, many CFIDS patients describe their lives as living hells. Why do we not read a steady stream of stories in gay publications about gay people coping with CFIDS? Some estimates of the number of people suffering from CFIDS in the United States go as high as 14 million. If we use the 5% number which is often used to estimate the number of gay people in America, where are the 700,000 cases of CFIDS in the gay community? How about just 100,000? That should still be a noticeable blip on the medical radar screen. The gay community has been living under a medical microscope for two decades. If there is a major contagious epidemic that is AIDS-like, one would think that there would be all kinds of studies of this AIDS-like epidemic in the gay community.

Some people seem to have made careers out of studying the illnesses of gay people. And yet one never hears of public health warnings about the transmission of CFIDS in the gay community. There are no gay CFIDS commissions, no gay CFIDS ribbons, no gay CFIDS subway posters, no GAY CFIDS benefits, no CFIDS quilts. If the worst estimate of CFIDS incidence is accurate, it would seem reasonable to suggest that for every gay AIDS patient a gay doctor has in his practice, he should have one or two--or more--gay CFIDS patients. And given the similarity of their symptoms, how does the doctor keep his patients straight? It is theoretically possible that a new AIDS patient will have more T-cells than an old CFIDS patient. If a gay person has the symptoms and immune abnormalities of CFIDS which look just like the symptoms and immune abnormalities of AIDS, and tests negative for HIV, is he given a clean bill of health? And why are gay doctors not warning the gay community about the possibility of contracting CFIDS and giving it to others? Gay people are issued every other imaginable kind of medical and lifestyle warning. Why none for CFIDS? Are we supposed to believe that the gay community is somehow miraculously immune to CFIDS? That would certainly be a fascinating finding. And perhaps a bogus one too.

There is a far more parsimonious explanation for why we don't hear about a massive CFIDS epidemic in the gay community. Let's just say for now that it is very curious that most CFIDS patients tend to be neither gay nor Black while most AIDS patients tend to be gay or Black or both. Nothing political is going on here, right? Gay men are told that the key to protecting their immune system is knowing the HIV antibody status of their partners. But what if their partners have CFIDS? Why are gay men and lesbians not warned to ask about the CFIDS status of their partners, and not urged to inform their partners if they have any CFIDS symptoms? For that matter, given that CFIDS has been presented by research an an essentially heterosexual AIDS-like illness, why are heterosexuals not warned about transmitting or contracting CFIDS? Where are CFIDS warning posters in heterosexual bars? Needless to say, I think there is a Pandora's Box of a story here. It is one that could lead to a change in the way we look at AIDS and CFIDS. It might even lead to a major medical and scientific paradigm shift. But for the time being, can someone just answer this simple question: where is the major epidemic of Chronic Fatigue Syndrome in the gay community?

This book explains why the CDC can never tell the gay community the truth about Chronic Fatigue Syndrome.

If you have Amazon Prime or Kindle Unlimited, you can immediately begin reading The Chronic Fatigue Syndrome Epidemic Cover-up and you will soon understand why the facts about the Chronic Fatigue Syndrome epidemic have been hidden from the public for almost four decades.

This is a must-read book for anyone who wants to know the disturbing history of the Chronic Fatigue Syndrome epidemic. Why have the CDC and NIH pretended that that the communicable disease fraudulently called "Chronic Fatigue Syndrome" is a mystery for over three decades? By the end of this book of inconvenient truths the answer is crystal clear. The shocking news and bold analysis in this page-turner could lead to a revolution in the science and politics of Chronic Fatigue Syndrome, fibromyalgia, AIDS, autism, and many other illnesses.

As the publisher and editor-in-chief of a small newspaper in New York, Charles Ortleb was the first journalist to devote a publication to uncovering the truth about Chronic Fatigue Syndrome. He assigned Neenyah Ostrom the duty of following every twist and turn of the Chronic Fatigue Syndrome story. No newspaper in the world did more to warn the world about the virus called HHV-6 which seems to be triggering Chronic Fatigue Syndrome and many other immunological disorders.

This provocative book will end the injustice of the silent treatment Neenyah Ostrom's reporting has been getting from the media and The Chronic Fatigue Syndrome community. Ostrom blew the lid off one of the biggest medical secrets of our time: the link between the Chronic Fatigue Syndrome epidemic and AIDS.

Ostrom interviewed most of the major researchers in the field, as well as countless patients and government scientists. She uncovered so many similarities between Chronic Fatigue Syndrome and AIDS that she came to the conclusion that they are part of the same epidemic, and she argued that until their connection is admitted by top government researchers, there is little hope of making real progress in the fight against Chronic Fatigue Syndrome.

Charles Ortleb's book captures all the challenges and excitement of running a small newspaper that was publishing a brilliant journalist who essentially was the Woodward and Bernstein of the Chronic Fatigue Syndrome epidemic. In Rolling Stone, David Black said Ortleb's newspaper deserved a Pulitzer Prize.

 Hillary Johnson, the author of Osler's Web, called it "A rollicking, fascinating and important memoir."

books on kindle

Two books on amazon

Everyone needs to know what the CDC is hiding about CFS and HHV-6. NEW YORK NATIVE contains both volumes of THE CHRONIC FATIGUE SYNDROME EPIDEMIC COVER-UP. The print version is $23. Only $7.98 in Kindle.

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