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Human Herpes Virus 6 variant A (HHV-6A) directly linked to multiple sclerosis-like illness.

Evidence Presented at American Neurology Association Annual Meeting SAN DIEGO, Oct. 5, 2005 (PRIMEZONE) -- Dr. Claude Genain of the University of California San Francisco Medical Center presented evidence at the American Neurology Association Annual Meeting this week that shows a direct link between human herpes virus 6 variant A (HHV-6A) and a multiple sclerosis-like illness. Dr. Genain injected common marmoset monkeys with HHV-6 variants A & B. Most notably, only infection with HHV-6 variant A resulted in illness. The monkeys developed lab evidence and signs of chronic autoimmune demyelination of the central nervous system, the hallmark of multiple sclerosis. This is the first time that any animal infected with HHV-6A has developed clinical pathology of the central nervous system, and the most direct evidence to date of a possible causal connection between HHV-6A and multiple sclerosis. Dr. Genain's marmoset developed weight loss and paralysis with sensory deficits af...

Bhupesh Prusty, Konnie Knox, and Brigitte Huber have done the most important research on HHV-6. Why is Huber's retroviral finding about HHV-6 being ignored????

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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...

A superantigen may link HHV-6, AIDS, COVID, and Chronic Fatigue Syndrome.

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Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis Frontiers | Multisystem Inflammatory Syndrome in Children and Long COVID: The SARS-CoV-2 Viral Superantigen Hypothesis (frontiersin.org)   HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies....

Why Brigitte Huber may be the most important AIDS and Chronic Fatigue Syndrome researcher

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  HHV-6A infection induces expression of HERV-K18-encoded superantigen Albert K. Taia, Janos Lukab, Dharam Ablashi, Brigitte T. Huber published online 08 June 2009. Abstract Background The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein–Barr virus (EBV) infection and IFN-α treatment. Objectives Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other herpesviruses would have similar HERV-K18 transactivation properties. Human herpesvirus (HHV)-6A, a neurotropic virus associated with multiple sclerosis, was a logical candidate for these studies. Study design HSB2 cells (HHV-6-negative control), HSB2-ML cells (containing latent HHV-6A genome) and HSB2/HHV-6A cells (HSB-2 cells productively infected with HHV-6A) were compared for their level of HERV-K18 transcription, using quantitative RT...

The cat is out of the bag!

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Tweet Antiretrovirals for Multiple Sclerosis may finally be the undoing of the HIV/AIDS paradigm  and point to HHV-6 as the AIDS virus, the Chronic Fatigue Syndrome virus, the Alzhemier's virus, etc. https://www.sciencedirect.com/science/article/pii/S2211034818300828 Why did they avoid talking about HHV-6? Check out these links from the HHV-6 Foundation Below are a few highlighted findings from the literature on the proposed relationship between HHV-6 and MS HHV-6A/B IgG correlates with relapse and progression in MS ( Ortega-Madueno 2014 ) HHV-6A lytic antigen is target of HHV-6 specific oligcolonal bands in MS ( Alenda 2014 ) HHV-6A infection causes persistent neuroinflammation via TLR9 in CD46 transgenic mice ( Reynaud 2014 ) HHV-6 IgG but not EBV antibody titers predict relapse in multiple sclerosis ( Simpson 2012 ) MS patients have increased prevalence and titer of IgG antibodies reactive to HHV-6 U94/REP Protein ( Ben Fredj 2013 ) Marmosets inoculated wit...

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