HHV-6 University

Click here to see all the cartoons on this site.  If you like our cartoons, you'll love Julian Lake's collection: The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies. [Kindle Edition available on Kindle Unlimited]

Why it's about to get a lot harder to hide the results of medical studies   http://www.vox.com/2014/12/6/7344357/clinical-trials-transparency

If you like our cartoons, you'll love Julian Lake's collection: The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies. [Kindle Edition available on Kindle Unlimited]

Books on HHV-6 and Chronic Fatigue Syndrome that are free to read if you have Kindle Unlimited . The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies. [Kindle Edition available on Kindle Unlimited] The Closing Argument by Charles Ortleb (Available on Kindle and in a Print Edition. Free for Kindle owners with Amazon Prime.)

If you like our cartoons, you'll love Julian Lake's collection: The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies. [Kindle Edition available on Kindle Unlimited]

                                                                                           Julian Lake Julian Lake's The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies . [Kindle Edition available on Kindle Unlimited] The title of this collection of cartoons by Julian Lake was inspired by the The March of Folly , a stunning work by the late Barbara Tuchman. To try and explain why certain political disasters in history have occurred, Tuchman uses the very apt construct of "folly," which she ...

" . . .this virus subverts innate immune signaling through engagement of different co-receptors that ultimately decide the fate of virus infection."   http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0113962 Wikipedia on The Innate Immune System   http://en.wikipedia.org/wiki/Innate_immune_system The innate immune system , also known as the nonspecific immune system and the first line of defense, [ 1 ] is a subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. This means that the cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates ), it does not confer long-lasting or protective immunity to the host. [ 2 ] Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunit...

Julian Lake's CFS cartoon book on Kindle (free on Kindle Unlimited).

Julian Lake's CFS cartoon book on Kindle (free on Kindle Unlimited).

Changes in cerebrospinal fluid biomarkers in human herpesvirus-6-associated acute encephalopathy/febrile seizures. http://www.ncbi.nlm.nih.gov/pubmed/25294958   Abstract To determine the involvement of oxidative stress in the pathogenesis of acute encephalopathy associated with human herpesvirus-6 (HHV-6) infection, we measured the levels of oxidative stress markers 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL), tau protein, and cytokines in cerebrospinal fluid (CSF) obtained from patients with HHV-6-associated acute encephalopathy (HHV-6 encephalopathy) (n = 16) and complex febrile seizures associated with HHV-6 (HHV-6 complex FS) (n = 10). We also examined changes in CSF-8OHdG and CSF-HEL levels in patients with HHV-6 encephalopathy before and after treatment with edaravone, a free radical scavenger. CSF-8-OHdG levels in HHV-6 encephalopathy and HHV-6 complex FS were significantly higher than in control subjects. In contrast, CSF-HEL le...

http://www.washingtonpost.com/blogs/style-blog/wp/2014/12/02/no-youre-not-sleeping-enough-and-its-a-big-problem-15-scary-facts-in-new-natgeo-doc/?hpid=z4

http://hhv-6foundation.org/associated-conditions/hhv-6-and-immune-suppression

http://news.yahoo.com/hivs-ability-cause-aids-weakening-over-time-study-200113825.html                                                                                                      Julian Lake Julian Lake's CFS cartoon book on Kindle (free on Kindle Unlimited).

http://www.ncbi.nlm.nih.gov/pubmed/25433843

Human herpesvirus type 6 indirectly enhances oligodendrocyte cell death.  http://www.ncbi.nlm.nih.gov/pubmed/13129768 Abstract Accumulating evidence suggests that human herpesvirus type 6 (HHV-6) plays a pathogenic role in diseases of the central nervous system including multiple sclerosis (MS). Recent studies have indicated that HHV-6 DNA is detected with high frequency in MS lesions compared to normal-appearing white matter, implicating a role for HHV-6 in MS pathogenesis. It appears that T cells, which infiltrate into the brain in MS patients, and resident oligodendrocytes harbor HHV-6 virus in MS lesions. Because T cells infected with HHV-6 have elevated proinflammatory gene expression, we hypothesized that HHV-6 could be indirectly cytotoxic to glial cells, including oligodendrocytes. Supernatants from SupT1 cells infected with HHV-6 variant A (GS or U1102) or variant B (Z29) significantly reduced MO3.1 cell proliferation by 75% +/- 10%, 78% +/- 8% or 51% ...

http://figshare.com/articles/Mitochondrial_Dysfunction_and_Chronic_Fatigue_Syndromes_Issues_in_Clinical_Care_modified_version_/1254859

Julian Lake's CFS cartoon book on Kindle (free on Kindle Unlimited).

HHV-6 infection in HIV-infected asymptomatic and AIDS patients.  http://www.ncbi.nlm.nih.gov/pubmed/9705559 Abstract In order to investigate the levels of HHV-6 infection and elevated antibodies to HHV-6 in HIV-1-infected asymptomatic and symptomatic patients, peripheral blood mononuclear cells were (PBMC) cultured. As patients progressed from asymptomatic HIV infection to AIDS, there was a concurrent increase in replicating HHV-6. Plasma obtained from several of these patients showed the presence of IgM antibody and a significantly elevated level of HHV-6 IgG antibody. Serial samples of plasma from 10 AIDS patients collected over a period of 4 years were assayed for the detection of HHV-6 core protein (gp116/64/54) by antigen capture ELISA. The results demonstrated that either a persistent infection or reactivation can occur based on the degree of fluctuation in HHV-6 antigen detected. ELISA to HHV-6 purified viral proteins, i.e., early (p41/38) and late (gp11...

http://www.sciencedirect.com/science/article/pii/S1386653214004545

Chronic fatigue syndrome and fibromyalgia following immunization with the hepatitis B vaccine: another angle of the 'autoimmune (auto-inflammatory) syndrome induced by adjuvants' (ASIA).   http://www.ncbi.nlm.nih.gov/pubmed/25427994   Abstract The objectives of this study were to gather information regarding demographic and clinical characteristics of patients diagnosed with either fibromyalgia (FM) or chronic fatigue (CFS) following hepatitis B vaccination (HBVv) and furthermore to apply the recently suggested criteria of autoimmune (auto-inflammatory) syndromes induced by adjuvants (ASIA), in the aim of identifying common characteristics that may suggest an association between fibromyalgia, chronic fatigue and HBV vaccination. Medical records of 19 patients with CFS and/or fibromyalgia following HBVv immunization were analyzed. All of which were immunized during 1990-2008 in different centers in the USA. All medical records were evaluated for demograph...

Viral pathogens in children hospitalized with features of central nervous system infection in a malaria-endemic region of Papua New Guinea http://www.biomedcentral.com/1471-2334/14/630/abstract

HHV-6 University Cartoons

These two unique books about CFS and HHV-6 are available on Kindle Unlimited. The Chronic Fatigue Syndrome Follies: Cartoons about an epidemic of lies. [Kindle Edition] A collection of cartoons about the cover-up of the Chronic Fatigue Syndrome epidemic. Anyone who knows the whole sorry story about the Chronic Fatigue Syndrome epidemic will tell you that it is one of the great tragedies in world history. A syndrome with so many similarities to AIDS that it has been called "AIDS Minor," CFS has been swept under the rug for three decades while millions of people have seen every aspect of their lives ruined. Patients have trouble deciding whether the government scientists in charge of researching it are liars or just plain stupid and incompetent. In other word,s CFS is the perfect subject for the pen of a caustic satirist. Cartoonist Julian Lake has used his sharp wit to capture the absurdities of a vast epidemic that has been hidden in plain sight by medi...

"HERV-K18 causes massive T-Cell activation"  "Superantigen wreaks havoc in the immune system?" HHV-6A infection induces expression of HERV-K18-encoded superantigen  http://www.sciencedirect.com/science/article/pii/S1386653209001942

 HERVK-18 AS RISK FACTOR FOR CFIDS DESCRIPTION (provided by applicant): The etiology of Chronic Fatigue Syndrome (CFS) is far from understood and is likely due to multiple genetic components. Infection with EBV and treatment with IFN-a have been implicated in the pathogenesis. Our laboratory has shown that EBV-infection, and exogenous IFN-a?, activate transcription of the env gene of a Human Endogenous Retrovirus, HERV-K18. This provirus is normally silent, but when induced it encodes a superantigen (SAg), which is a class of proteins that is capable of deregulating the immune system. Three alleles of HERV-K18 env have been documented, K18.1, K18.2, K18.3, whose gene products have SAg activity, but are predicted to differ biochemically and functionally. Our working hypothesis is that HERV-K18 is a risk factor for CFS. In a pilot study, the allele and genotype distributions of the HERV-K18 env gene were compared between various groups of CFS patients and healthy contr...

    Dendritic cells (DCs) are antigen-presenting cells , (also known as accessory cells ) of the mammalian immune system . Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and the adaptive immune systems . Source: http://en.wikipedia.org/wiki/Dendritic_cell Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells "OBJECTIVE:Monocyte-derived dendritic cells (DCs) play important roles in the immune response against infections and malignancies. Human herpesvirus 6 (HHV-6) infects monocytes and is reactivated in immunodeficient patients. To clarify the mechanisms of HHV-6-induced immunodeficiency, we investigated the effect of HHV-6 infection on differentiation of monocytes to DCs." http://www.ncbi.nlm.nih.gov/pubmed/16647570 Phenotypic and functional alterations of dendritic cells induced by human herpesvirus 6 infection. ...

    Cartoons about an epidemic of lies. Available November 30! A collection of cartoons about the cover-up of the Chronic Fatigue Syndrome epidemic. Anyone who knows the whole sorry story about the Chronic Fatigue Syndrome epidemic will tell you that it is one of the great tragedies in world history. A syndrome with so many similarities to AIDS that it has been called "AIDS Minor," CFS has been swept under the rug for three decades while millions of people have seen every aspect of their lives ruined. Patients have trouble deciding whether the government scientists in charge of researching it are liars or just plain stupid and incompetent. In other word,s CFS is the perfect subject for the pen of a caustic satirist. Cartoonist Julian Lake has used his sharp to capture the absurdities of a vast epidemic that has been hidden in plain sight by medical authorities who have put the whole world at risk. But sufferers of CFS are no different from the victims of a...

Times finally acknowledges changes in the brains of CFS patients. http://well.blogs.nytimes.com/2014/11/24/brains-of-people-with-chronic-fatigue-syndrome-offer-clues-about-disorder/?partner=rss&emc=rss&_r=1

" Both intrauterine and sexual transmission of human herpesvirus ( HHV)-6 and HHV-7 have been suggested." http://www.ncbi.nlm.nih.gov/pubmed/17922393 " Transmission of this virus is believed to occur as a result of exposure to saliva." http://www.emergingworlds.com/ch_viruses_detail.cfm?vPageid=41  " Human herpesvirus 6 ( HHV - 6 ) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV - 6 DNA."   http://www.ncbi.nlm.nih.gov/pubmed/15170644 " HHV-6 has a very high prevalence (close to 100% of the world’s population has been exposed). It is transmitted mainly by saliva. Transmission occurs usually within the first two years of life; primary infection is often associated with a febrile condition and sometimes with the onset of roseola (exanthem subitum). Two variants of the virus are known, HHV-6A and HHV-6B. HHV-6 is mainly lymphotropic, infecting a broad rang...

Our HHV-6 Pandemic Cartoons

Posts on HHV-6 and Endogenous Retroviruses

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 Great article on Salon from Alternet P.S. A multisystemic pandemic of HHV-6 doesn't help.

http://www.morgellons.org/case_definition.htm

http://en.wikipedia.org/wiki/Glioblastoma_multiforme  "Glioblastoma has been associated with the viruses HHV-6 , and cytomegalovirus."

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If you like this cartoon you'll love this hilarious little book. The Chronic Fatigue Syndrome Follies [Paperback]  http://www.amazon.com/The-Chronic-Fatigue-Syndrome-Follies/dp/product-description/0966345487

Epidemiology of Herpes Human Virus 6 and 7 Infections in Salivary Gland Neoplasms in Isfahan, Iran http://www.academia.edu/7979518/Epidemiology_of_Herpes_Human_Virus_6_and_7_Infections_in_Salivary_Gland_Neoplasms_in_Isfahan_Iran "HHV-6 and the HHV-7 have been identified as one of the most im portant oncogenic viruses "

http://sciencenordic.com/first-image-irritable-bowel

http://books.google.com/books?id=aEUkBAAAQBAJ&pg=PA128&lpg=PA128&dq=hhv+-6+microbiome&source=bl&ots=i76kTibOxb&sig=VLcvOuJ7PtGRC0T6Ect1ukPmMb4&hl=en&sa=X&ei=9rxuVN_KG4yigwTngYP4AQ&ved=0CCAQ6AEwAA#v=onepage&q=hhv%20-6%20microbiome&f=fals e HHV-8 and Chronic Fatigue Syndrome Prevalence in the cerebrospinal fluid of the following infectious agents in a cohort of 12 CFS subjects: human herpes virus-6 and 8; chlamydia species; mycoplasma species; EBV; CMV; and Coxsackievirus. Levine, S. Journal of Chronic Fatigue Syndrome, 2001, 9, 1/2, 41-51. Abstract: Over the last decade a wide variety of infectious agents have been associated with the CFS as potential etiologies for this disorder. Many of these agents are neurotrophic and have been linked previously to other diseases involving the central nervous system (CNS). Human herpes virus-6 (HHV-6), especially the B variant, has been found in autopsy specimens of patients who suffered f...

http://stonebird.co.uk/experience/paralysis.html

New oral medication, PRID-201, shows promise in treating fibromyalgia http://www.news-medical.net/news/20141118/New-oral-medication-shows-promise-in-treating-fibromyalgia.aspx  "Many herpes viruses are known to significantly upregulate COX enzymes in the body, which in turn are important for efficient viral replication," Pridgen said. "In theory, physical or emotional stress in patients can reactivate the virus and result in perpetuation of the symptoms of fibromyalgia. Effectively suppressing latent viruses may significantly improve the pain and related symptoms of FM."