Steve Jacobson on HHV-6


Human herpesvirus-6 entry into the central nervous system through the olfactory pathway

Abstract

Viruses have been implicated in the development of neurodegenerative diseases, such as Alzheimer's, Parkinson’s, and multiple sclerosis. Human herpesvirus-6 (HHV-6) is a neurotropic virus that has been associated with a wide variety of neurologic disorders, including encephalitis, mesial temporal lobe epilepsy, and multiple sclerosis. Currently, the route of HHV-6 entry into the CNS is unknown. Using autopsy specimens, we found that the frequency of HHV-6 DNA in the olfactory bulb/tract region was among the highest in the brain regions examined. Given this finding, we investigated whether HHV-6 may infect the CNS via the olfactory pathway. HHV-6 DNA was detected in a total of 52 of 126 (41.3%) nasal mucous samples, showing the nasal cavity is a reservoir for HHV-6. Furthermore, specialized olfactory-ensheathing glial cells located in the nasal cavity were demonstrated to support HHV-6 replication in vitro. Collectively, these results support HHV-6 utilization of the olfactory pathway as a route of entry into the CNS.
Erin Harbertsa
Karen Yaoa
Jillian E. Wohlera,
Dragan Maricc,
Joan Ohayona,
Robert Henkind, and
Steven Jacobson
Edited by Robert C. Gallo, Institute of Human Virology, University of Maryland, Baltimore, Baltimore, MD,
http://www.pnas.org/content/early/2011/08/01/1105143108.abstract
"Virologist Dharam Ablashi, who codiscovered HHV-6 and now is scientific director of the HHV-6 Foundation in Santa Barbara, Calif., says the results may be just the tip of an iceberg. 'As research techniques improve,' he says, 'we may find that most neurological conditions are caused by viruses that enter the brain through the nasal passages.'"
http://www.sciencenews.org/view/generic/id/333083/title/Commonvirusmayrideupnoseto_brain

Popular Posts in the Last 7 Days

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

An op-ed about CFS and AIDS written by Perplexity A.I.

Does inflammation cause the reactivation of endogenous retroviruses, some with pathological potential?

From Perplexity A.I.

Perplexity A.I. creates "Nosology Man"

Popular Post in the Last 30 Days

" A new study finds that prior herpesvirus infections are linked to a faster age-related increase in blood biomarkers associated with dementia, even in cognitively healthy women. Researchers measured five key biomarkers in 167 women and found that seropositivity for HHVs doubled the rate of biomarker accumulation compared to those without prior infection. The strongest viral associations were seen for Epstein-Barr virus and HHV6, with amyloid-beta and phosphorylated tau levels most affected. These findings support the hypothesis that chronic viral infections may accelerate neurodegeneration and raise dementia risk independently of genetic factors."

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

Pigs with ASFV also develop hypovolemia?

A satirical story about in which AIDS activists get involved in promoting and defending science that turns out to be totally wrong and backfires on them

Perplexity A.I. creates "Nosology Man"

Popular Posts from the Last Year

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

Dr. Rebecca Culshaw Smith's book is discussed on Twitter

A fictional discussion of AIDS between Senator Rand Paul and Rebecca Culshaw Smith

Ablashi discusses HHV-6, AIDS, Alzheimer's, and Chronic Fatigue Syndrome

Doctors discuss using Chloroquine for COVID-19

Is African Swine Fever a threat to human health in Congo?

All Time Most Popular Posts

Dr. Bhupesh Prusty and Professor Thomas Rudel discuss their HHV-6 research

Anthony Fauci was part of the gang that silenced and destroyed Judy Mikovits.

Was Judy Mikovits destroyed because her XMRV work would have ultimately shown HIV is a total fraud?

Is Chronic Fatigue Syndrome the other AIDS epidemic in the gay community?