HHV-6 and B-cells

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Activation of the Epstein-Barr virus replicative cycle by human herpesvirus 6.

L Flamand, I Stefanescu, D V Ablashi, and J Menezes
J Virol. 1993 November; 67(11): 6768–6777
"Interestingly, human B-cells appear to be particularly susceptible to HHV-6 infection in vitro only if they have been previously infected with EBV." http://www.ncbi.nlm.nih.gov/pmc/articles/PMC238118/?page=1
"The detection of HHV-6 genomic sequences in some B-cell neoplasias and the potential of an HHV-6 genomic segment in transforming rodent cells suggests a possible, if indirect, role for the virus in certain cancers."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC238118/?page=2
"It can tentatively be hypothesized that HHV-6 activates EBV in B-cells by inducing the immediate-early transactivator, Zebra." http://www.ncbi.nlm.nih.gov/pmc/articles/PMC238118/?page=7
"By inducing EBV, HHV-6 may, therefore, contribute to the increase of the B-cell pool infected with EBV, thereby increasing the chances of developing an EBV-related lymphoma. Taken together the present study illustrates the inteactions between two viruses, both belonging to the same family, which can infect B lymphocytes."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC238118/?page=8
"We have demonstrated that infection of EBV genome-positive cells by HHV-6 leads to reactivation of EBV."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC238118/?page=8

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