HHV-6 and Endothelial Cells

Infection of Endothelial Cells by Human Herpesvirus-6 Is Associated With Profound Changes in the Healing Process, With Possible Consequences for Cardiac Disease and Cancer

BALTIMORE, MD--(eMediaWorld - June 27, 2008) - A new study suggests for the first time that human herpesvirus 6 (HHV-6) infects and persists in a dormant state in endothelial cells, the cells lining blood vessels, and causes these cells to lose their ability to grow, to form new blood vessels, and to take part in healing processes. This finding was announced at the 6th International Conference for HHV-6 & 7 by a team of Italian researchers, professors Arnaldo Caruso of the University of Brescia and Dario Di Luca of the University of Ferrara.
The experiments performed on pure endothelial cells grown in the laboratory allowed Professors Caruso and Di Luca to discover that U94, a viral protein produced during the viral latency, is responsible for these biological effects. In fact, during the conference, German researchers reported that HHV-6 is found in cardiomyopathy. "It is possible that the expression of U94 damages endothelial cells of the heart, causing the disease or delaying recovery," said Dr. Di Luca. "The understanding of this phenomenon could be important for the diagnosis and management of some heart diseases," he added.
An impact on tumor-fighting therapies?
The production of new blood vessels (angiogenesis) is a very important biological process that occurs naturally in the body. However, an excess of angiogenesis can be harmful. If tumors do not form new blood vessels, they do not receive enough blood with the necessary nutrients and cannot grow. Therefore, blocking angiogenesis is important for stopping tumor growth. Currently, the Italian research team is performing advanced experiments toward the development of new anti-tumor therapies based on the inhibition of blood vessel formation by U94. The production of U94 might limit tumor growth by preventing the formation of new blood vessels.
Human herpesvirus 6 (HHV-6) is a virus commonly found in healthy adults. The virus infects for the first time during early childhood, causing a few days of fever and a temporary skin rash; spontaneous healing quickly occurs. After this first encounter with the body, the virus persists in a dormant state. This life-long latent infection usually does not cause any disease. However, the virus can activate, usually in patients with immune deficiencies or taking immune suppressive drugs, and can cause life- threatening diseases. Other researchers have reported that HHV-6 may be linked also to diseases of the central nervous system, such as multiple sclerosis, encephalitis, chronic fatigue syndrome and epilepsy.

---

HHV-6 infects human aortic and heart microvascular endothelial cells, increasing their ability to secrete proinflammatory chemokines.

Caruso A, Rotola A, Comar M, Favilli F, Galvan M, Tosetti M, Campello C, Caselli E, Alessandri G, Grassi M, Garrafa E, Cassai E, Di Luca D.
Institute of Microbiology, University of Brescia Medical School, Italy.
Endothelial cells are important targets for herpesvirus infection. To evaluate the biological effects of human herpesvirus-6 (HHV-6) infection, adult heart microvascular and aortic endothelial cells were examined for in vitro susceptibility to HHV-6 and for the alterations induced by viral infection on the production of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8). Analysis by reverse transcription-polymerase chain reaction and by in situ polymerase chain reaction showed that HHV-6 replicates in endothelium in the absence of cytopathic effects, and that viral sequences were present in 20% umbilical vein and in 10% aortic and 1% microvascular endothelium. HHV-6 infection upregulated the production of MCP-1 and IL-8, with differences observed between aortic and microvascular endothelium. These findings demonstrate that endothelial cells represent a potential reservoir for HHV-6 infection, and the altered pattern of chemokine production can lead to attraction of immunocompetent cells and to the development of inflammatory processes. Copyright 2002 Wiley-Liss, Inc.
J Med Virol. 2002 Aug;67(4):528-33.


If HHV-6 is the real cause of AIDS, here are some of the implications:

1. HIV is a massive scientific fraud. Something akin to a Ponzi scheme. Scientists who challenged the HIV theory of AIDS (the ones who have been thuggishly censored and silenced) turn out to be on the money.

2. Chronic Fatigue Syndrome and Autism (and many other so-called HHV-6 related mysterious epidemics) are part of the so-called AIDS epidemic.  Chronic Fatigue Syndrome and Autism both are clearly the results of the ravages of HHV-6.

3. AIDS and Chronic Fatigue Syndrome has been artificially and politically separated into two epidemics. We are living in a period of CFS/AIDS apartheid. So-called AIDS patients have to sit in the back of the HHV-6 epidemic bus while the befuddled HHV-6/CFS patients and HHV-6/Autism victims sit up front. Nobody is well-served.

4. AIDS is not a sexually transmitted disease. That paradigm has set a scapegoating and antigay agenda in place that the public thinks is solidly based on science. It is only based on homophobic and racist nosology, epidemiology and virology. The scientists behind the paradigm are charlatans and crooks.

5. The Centers for Disease Control in Atlanta and the Pasteur Institute in Paris have a great deal in common with the institutions of Nazi medicine. For Blacks, everything these institutions have done in the name of AIDS really constitutes a second Tuskegee Syphilis Experiment.

Elements of a Scientific Ponzi Scheme like the Montagnier-Agut HIV Fraud Ponzi Scheme and HHV-6 Cover-up

A scientific Ponzi scheme begins with a central seminal or foundational scientific fraud and is  sometimes built on an infrastructure of smaller scientific frauds. Like the fake dividends issued in a strictly financial Ponzi scheme, a scientific Ponzi scheme issues fake dividends in the form of ongoing fraud-based research often framed as "breakthroughs" and bogus extrapolations which make it look like everything is above board and that what, in reality, is scientific fraud, appears to the rest of the scientific community and the public as good faith progress.

A classic scientific Ponzi scheme like the Montgnier-Agut HIV Fraud Ponzi Scheme and HHV-6 Cover-up include elements like these:

1. Nosological fraud.

2. Epidemiological fraud.

3. Virological fraud.

4. Treatment fraud.

5. Public health policy fraud.

6. Concealment of negative scientific data and paradigm-challenging anomalies.

7.  Use of an elite network of "old boys" and pseudo-activist provocateurs to censor critics and whistleblowers.

8. Chronic obscurantism.

9. If necessary, vigilantism and witch-hunts against any intellectuals, scientists, or citizens who constitute any form of resistance to the Ponzi scheme.

10. A subservient scientific press that is used as a conveyor belt for the Ponzi scheme's propaganda.

Everything always looks like it is working perfectly in a Ponzi scheme, until the moment comes when someone look at the books and blows the whistle.  Hopefully, that game-changing moment for the Montagnier-Agut HIV Fraud Ponzi Scheme and HHV-6 Cover-up is coming soon.