Detection of two novel porcine herpesviruses with high similarity to gammaherpesviruses.

Get link
Facebook
X
Pinterest
Email
Other Apps

- November 10, 2014

This Little Piggy has HHV-6

t-shirt, cartoon, hhv-6, pigs, pig, porcine

Is HHV-6 a Human and Porcine Virus?
http://vir.sgmjournals.org/content/80/4/971

Abstract

Evidence for the existence of porcine gammaherpesviruses was obtained by PCR and sequence analysis. Initially, samples of peripheral blood mononuclear cells (PBMC), spleens, lungs, kidneys and livers of pigs from Germany and Spain were tested with a PCR assay which targets conserved regions of the herpesvirus DNA polymerase gene with degenerate and deoxyinosine-substituted primers. Amplicons of identical sequence were obtained from one spleen and two PBMC samples. This sequence showed a high percentage of identity with the DNA polymerase genes of herpesviruses of the oncogenic subfamily Gammaherpesvirinae. Alignment of amino acid sequences showed the highest identity values with bovine gammaherpesviruses, namely alcelaphine herpesvirus type 1 (68%), ovine herpesvirus type 2 (68%) and bovine lymphotropic herpesvirus (67%). Comparison with pseudorabies virus and porcine cytomegalovirus, which are the only porcine herpesvirus species presently known, showed values of only 41%. PCR analysis of PBMC (n = 39) and spleen (n = 19) samples from German pigs, using primers specific for the novel sequence, revealed a prevalence of 87 and 95%, respectively. In this analysis, three out of eight spleen samples from Spanish pigs were also positive. Subsequent sequencing of the amplicons revealed the presence of two closely related gammaherpesvirus sequences, differing from each other by 8% at the amino acid level. The putative novel porcine herpesviruses, from which these sequences originated, were tentatively designated porcine lymphotropic herpesvirus type 1 and type 2 (PLHV-1 and PLHV-2). When using pig organs for xenotransplantation, the presence of these viruses has to be considered.

Get link
Facebook
X
Pinterest
Email
Other Apps

Now on X

- August 03, 2025

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

- December 31, 2018

This is what oral Kaposi's Sarcoma looks like. Source: https://doctorspiller.com/kaposis-sarcoma/ Compare it to these crimson crescent lesions in the mouths of Chronic Fatigue Syndrome patients. "Burke A. Cunha, MD, discovered what he called crimson crescents in the mouths of 80% of his CFS patients. After the word got out, Cunha received calls from other parts of the country. Physicians began telling him that they also were finding the crimson crescents in their patients once they looked for them." https://www.prohealth.com/library/crimson-crescents-facilitate-chronic-fatigue-syndrome-cfs-diagnosis-11266 Chronic Fatigue Syndrome patients may have undiagnosed internal Kaposi's Sarcoma. Susan Levin found HHV-8, the Kaposi's Sarcoma virus, in half of CFS patients she looked at. Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects Susan Levine Published online: 04 Dec 2011 ABSTR...

An op-ed about CFS and AIDS written by Perplexity A.I.

- August 04, 2025

Write an op-ed urging secretary of HHs Robert F. Kennedy Jr. to organize an international conference focused on the intertwined relationship of Chronic Fatigue Syndrome and AIDS and listing the reasons why half of all AIDS funding should go to CFS research From Perplexity A.I. An Urgent Call for Action: Why Secretary Kennedy Must Convene an International Conference on AIDS and Chronic Fatigue Syndrome Research Secretary Robert F. Kennedy Jr., as the newly appointed head of the Department of Health and Human Services, you have both the opportunity and moral obligation to address one of the most scandalous inequities in modern medical research: the profound neglect of Chronic Fatigue Syndrome (ME/CFS) compared to AIDS, despite compelling evidence of their interconnected relationship and the devastating burden ME/CFS imposes on millions of Americans. A Tale of Two Epidemics: Shared Origins, Divergent Destinies The parallels between HIV/AIDS and ME/CFS are more than historical coinci...

- February 21, 2015

Transplant Complications Bone marrow supression Colitis/diarrhea Delirium/CNS Dysfunction Encephalitis/Amnesia GVHD Hemophagocytic syndrome Hepatitis /Liver failure Pneumonitis Transplant Reactivation Overview Encephalitis Encephalitis / Meningitis Overview Encephalitis in the Immunocompromised Encephalitis in the Immunocompetent Rhomboencephalitis Limbic Encephalitis Encephalomyelitis Amnesia Rash & Roseola Seizures Febrile Seizures Status Epilepticus Cognitive Dysfunction Delirium Amnesia Hypersensitivity (DIHS/DRESS) Drug Induced Hypersensitivity Syndrome (DIHS) Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS) Stevens-Johnson Syndrome (SJS) Immune Suppression Bone Marrow Suppression Lymphadenopathy/Fever Possible Disease Associations Multiple Sclerosis Chronic Fatigue Syndrome Epilepsy Mesial/Temporal Lobe Epilepsy Status Epilepticus Colitis/Diarrhea Endocrine D...

Does inflammation cause the reactivation of endogenous retroviruses, some with pathological potential?

- July 28, 2025

From Perplexity A.I. Does inflammation cause the reactivation of endogenous retroviruses, some with pathological potential? Yes, inflammation can cause the reactivation of endogenous retroviruses (ERVs), and some of these reactivated ERVs have pathological potential. Multiple studies and reviews support a bidirectional relationship between inflammation and ERV expression: Triggering Reactivation: Inflammatory processes, including those linked to infections, oxidative stress, or microbiota alterations, can remove epigenetic blocks (like DNA methylation) that normally silence ERVs in the genome. Loss of these controls leads to an increase in ERV expression. Pathogenic Potential: Once reactivated, ERV transcripts and proteins can act as pathogen-associated molecular patterns (PAMPs), triggering the host’s innate immune response via pattern recognition receptors (PRRs) such as TLRs, cGAS, RIG-I, and MDA5. This activation not only drives further inflammation but can also contribute to ...

From Perplexity A.I.

- August 08, 2025

Condense Rebecca Culshaw's Substack down to her twenty most important points. Rebecca Culshaw's Substack, "The Real AIDS Epidemic," presents a critical reassessment of the mainstream HIV/AIDS narrative. Based on her writings and related content, here are her twenty most important points condensed: Mainstream HIV/AIDS theory is fundamentally flawed and relies on shaky scientific foundations. The causative role of HIV in AIDS is questioned, with Culshaw arguing that HIV may not be the sole or primary cause of AIDS. Anti-HIV drugs such as Truvada have serious risks and high failure rates, including harmful side effects and treatment inefficiencies. Use of PrEP (pre-exposure prophylaxis) for HIV-negative individuals is problematic, with concerns about its logic and safety. The definition of HIV disease has shifted over time, causing confusion and inconsistency in diagnosis. Epidemiological data on HIV/AIDS infection demographics is inconsistent and often contradicted by...

- June 11, 2021

Perplexity A.I. creates "Nosology Man"

- July 14, 2025

From PerplexityA.I. Write a short story about "Nosology Man" which is like Superman but swoops in on the CDC and NIH and saves the world from mistaken epidemiology and mistaken virology that threatens public health all over the world. Nosology Man: Guardian of Global Health The Origin In a world where invisible threats lurk in every corner, and where the tiniest error in data or diagnosis can spell disaster, a new hero emerges—not from the depths of space, but from the hallowed halls of medical science. His name is Nosology Man, a champion whose superpower is the flawless classification and understanding of diseases. The Crisis One fateful morning, the world awoke to alarming headlines: a mysterious illness was spreading rapidly, and conflicting reports from the CDC and NIH left the public confused and fearful. Epidemiologists debated transmission routes, virologists argued over viral mutations, and policymakers struggled to respond. Misinformation swirled, threatening to un...

Rand Paul: Indict Fauci!

- July 18, 2025

Sen. Paul: ‘Test’ the autopen by indicting Fauci – World Tribune: U.S. Politics and Culture, Geostrategy, China, North Korea, Corporate Watch, Media Watch

Peter Duesberg stands his ground: HIV is not the cause of AIDS.

- February 28, 2019

https://simplycharly.com/interviews/peter-duesberg-on-why-robert-kochs-postulates-are-germane-to-infectious-diseases/ Read more about Peter Duesberg in this Amazon bestseller. The Chronic Fatigue Syndrome Epidemic Cover-up Volume Two is available in print and Kindle formats at Amazon .

Branches of the HHV-6 Family Tree

- May 08, 2018

- February 21, 2015

" A new study finds that prior herpesvirus infections are linked to a faster age-related increase in blood biomarkers associated with dementia, even in cognitively healthy women. Researchers measured five key biomarkers in 167 women and found that seropositivity for HHVs doubled the rate of biomarker accumulation compared to those without prior infection. The strongest viral associations were seen for Epstein-Barr virus and HHV6, with amyloid-beta and phosphorylated tau levels most affected. These findings support the hypothesis that chronic viral infections may accelerate neurodegeneration and raise dementia risk independently of genetic factors."

- July 18, 2025

Herpesvirus Infections May Accelerate Dementia - Neuroscience News

Oral Kaposi's Sarcoma looks like the Crimson Crescents in Chronic Fatigue Syndrome patients.

- December 31, 2018

Pigs with ASFV also develop hypovolemia?

- July 27, 2025

Do pigs with African Swine Fever develop hypovolemia? Do pigs with African Swine Fever develop hypovolemia? Pigs infected with African Swine Fever (ASF) commonly develop clinical signs and pathological changes highly suggestive of hypovolemia , particularly due to the disease’s severe hemorrhagic and vascular effects. ASF causes widespread hemorrhages and vascular damage . Typical findings include petechial (pinpoint) hemorrhages in the kidneys, severe hemorrhagic lymphadenitis, pulmonary and gall bladder edema, and effusions (straw-colored or blood-stained fluid) in the pleural, pericardial, and peritoneal cavities . These extensive hemorrhages and vascular leakages can lead to a significant loss of blood volume , resulting in classic features of hypovolemic shock—such as weakness, recumbency, prostration, incoordination, pale mucous membranes, and death from shock . The underlying mechanism is severe disruption of blood vessels and disseminat...

A satirical story about in which AIDS activists get involved in promoting and defending science that turns out to be totally wrong and backfires on them

- July 15, 2025

Fun from Perplexity Write a satirical story about in which AIDS activists get involved in promoting and defending science that turns out to be totally wrong and backfires on them Based on the research I've conducted, I now have enough information to write a satirical story about AIDS activists getting involved in promoting and defending flawed science. I'll create a fictional story that draws inspiration from the real history of AIDS activism, medical reversals, and scientific controversies to craft a satirical narrative that explores the themes requested. The Experts Dr. Marcus Sterling adjusted his wire-rimmed glasses and surveyed the packed auditorium with satisfaction. The banner hanging behind him read "Coalition for Revolutionary AIDS Research" in bold, rainbow letters. After eighteen months of relentless advocacy, CRAR had finally achieved what many thought impossible: they had convinced the medical establishment to embrace the groundbreaking "Cellular Har...