HHV-6 and Dendritic Cells

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 Dendritic cells.jpgDendritic cell revealed.jpg

 Dendritic cells (DCs) are antigen-presenting cells, (also known as accessory cells) of the mammalian immune system. Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and the adaptive immune systems.

Source: http://en.wikipedia.org/wiki/Dendritic_cell

Human herpesvirus 6 impairs differentiation of monocytes to dendritic cells

"OBJECTIVE:Monocyte-derived dendritic cells (DCs) play important roles in the immune response against infections and malignancies. Human herpesvirus 6 (HHV-6) infects monocytes and is reactivated in immunodeficient patients. To clarify the mechanisms of HHV-6-induced immunodeficiency, we investigated the effect of HHV-6 infection on differentiation of monocytes to DCs."

http://www.ncbi.nlm.nih.gov/pubmed/16647570

Phenotypic and functional alterations of dendritic cells induced by human herpesvirus 6 infection.

"The present data also suggest that the dysfunction of HHV-6-infected DCs is attributable mainly to impairment of the antigen capture and intracellular antigen-processing pathways."

http://www.ncbi.nlm.nih.gov/pubmed/12239310

 

 

 

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