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Showing posts from April, 2014

Kristin Loomis talks about HHV-6 and the Lipkin study

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http://www.cortjohnson.org/blog/2014/01/09/lipkin-study-vagus-nerve-hhv-6-loomis-hhv-6-foundation/  

HHV-6 and skin diseases

http://www.nature.com/jidsp/journal/v6/n3/full/5640056a.html

Possible role of human herpesvirus 6 as a trigger of autoimmune disease

http://www.ncbi.nlm.nih.gov/pubmed/24282390 Abstract Human herpesvirus 6 (HHV-6) infection is common and has a worldwide distribution. Recently, HHV-6A and HHV-6B have been reclassified into two distinct species based on different biological features (genetic, antigenic, and cell tropism) and disease associations. A role for HHV-6A/B has been proposed in several autoimmune disorders (AD), including multiple sclerosis (MS), autoimmune connective tissue diseases, and Hashimoto's thyroiditis. The focus of this review is to discuss the above-mentioned AD associated with HHV-6 and the mechanisms proposed for HHV-6A/B-induced autoimmunity. HHV-6A/B could trigger autoimmunity by exposing high amounts of normally sequestered cell antigens, through lysis of infected cells. Another potential trigger is represented by molecular mimicry, with the synthesis of viral proteins that resemble cellular molecules, as a mechanism of immune escape. The virus could also induce aberra

Human Herpesvirus 6 and Neuroinflammation (More support for HHV-6's involvement in CFS)

http://www.hindawi.com/journals/isrn.virology/2013/834890/ Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study. CONCLUSION: Neuroinflammation is present in widespread brain areas in CFS/ME patients and was associated with the severity of neuropsychologic symptoms.  http://www.ncbi.nlm.nih.gov/pubmed/24665088

Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: a cross-sectional study.

http://www.ncbi.nlm.nih.gov/pubmed/24555113

Reduction of Adverse Effects by a Mushroom Product, Active Hexose Correlated Compound (AHCC) in Patients With Advanced Cancer During Chemotherapy-The Significance of the Levels of HHV-6 DNA in Saliva as a Surrogate Biomarker During Chemotherapy.

http://www.ncbi.nlm.nih.gov/pubmed/24611562 Abstract Chemotherapy improves the outcome of cancer treatment, but patients are sometimes forced to discontinue chemotherapy or drop out of a clinical trial due to adverse effects, such as gastrointestinal disturbances and suppression of bone marrow function. The objective of this study was to evaluate the safety and effectiveness of a mushroom product, active hexose correlated compound (AHCC), on chemotherapy-induced adverse effects and quality of life (QOL) in patients with cancer. Twenty-four patients with cancer received their first cycle of chemotherapy without AHCC and then received their second cycle with AHCC. During chemotherapy, we weekly evaluated adverse effects and QOL via a blood test, EORTC QLQ-C30 questionnaire, and DNA levels of herpes virus type 6 (HHV-6) in saliva. The DNA levels of HHV-6 were significantly increased after chemotherapy. Interestingly, administration of AHCC significantly decreased the l

Identification of Chromosomally Integrated Human Herpesvirus 6 by Droplet Digital PCR.

http://www.ncbi.nlm.nih.gov/pubmed/?term=sedlak+ddpcr

Coinfection of Human Herpesviruses 6A (HHV-6A) and HHV-6B as Demonstrated by Novel Digital Droplet PCR Assay.

http://www.ncbi.nlm.nih.gov/pubmed/24663487 Abstract The human herpesviruses HHV-6A and HHV-6B have been associated with various neurologic disorders partly due to the detection of elevated viral DNA levels in patients compared to controls. However the reported frequency of these viruses varies widely, likely reflecting differences in PCR methodologies used for detection. Digital droplet PCR (ddPCR) is a third generation PCR technology that enables the absolute quantification of target DNA molecules. Mounting evidence of the biological differences between HHV-6A and HHV-6B has led to their recent reclassification as separate species. As it is now especially relevant to investigate each virus, our objectives were to first design a multiplex HHV-6A and HHV-6B ddPCR assay and then to investigate the incidence of HHV-6A and HHV-6B coinfection in samples from healthy donors and patients with MS, a disease in which HHV-6 is thought to play a role. In our assessment of hea

Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties.

http://www.jneurosci.org/content/24/20/4875/suppl/DC 1

Kaiser still won't provide Valcyte to HHV6 patient

A very important article on HHV-6 from 2006

http://www.dailymail.co.uk/health/article-386443/Is-cure-ME.html

An Old Interview with Hillary Johnson about Chronic Fatigue Syndrome

http://www.ncf-net.org/library/hillary.htm

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