Has anyone suggested that African Swine Fever virus acts like a superantigen?
Has anyone suggested that African Swine Fever virus acts like a superantigen? From Perplexity A.I. Superantigenic Activity in African Swine Fever Virus: Current Evidence and... Could HHV-6 and HHV-8 also act like superantigens The available evidence does not strongly support HHV-6 or HHV-8 acting as classical superantigens, but both viruses exhibit immune-modulating properties that share some functional parallels with superantigen activity: HHV-6 Immune Interactions T Cell Activation: HHV-6 preferentially infects activated CD4+ T cells and can also infect CD8+ T cells (HHV-6A). It induces proinflammatory cytokines (IL-6, CCL-1, Rantes) in infected olfactory ensheathing cells and PBMCs, but this is mediated through direct infection rather than non-specific T cell receptor (TCR) cross-linking. Cross-reactive T cell epitopes (e.g., HHV-6 U24 vs. myelin basic protein) exist, but these involve antigen-specific recognition rather than broad TCR Vβ activation. Immunomodulation: CD46 bind...