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Friday, July 13, 2018

Imagine if Lipkin's paper had included AIDS patients and read like this:

Insights into AIDS/myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics

The pathogenesis of AIDS/ME/CFS, a disease characterized by fatigue, cognitive dysfunction, sleep disturbances, orthostatic intolerance, fever, irritable bowel syndrome (IBS), and lymphadenopathy, is poorly understood. We report biomarker discovery and topological analysis of plasma metabolomic, fecal bacterial metagenomic, and clinical data from 50 AIDSME/CFS patients and 50 healthy controls. We confirm reports of altered plasma levels of choline, carnitine and complex lipid metabolites and demonstrate that patients with AIDS/ME/CFS and IBS have increased plasma levels of ceramide. Integration of fecal metagenomic and plasma metabolomic data resulted in a stronger predictive model of AIDS/ME/CFS (cross-validated AUC = 0.836) than either metagenomic (cross-validated AUC = 0.745) or metabolomic (cross-validated AUC = 0.820) analysis alone. Our findings may provide insights into the pathogenesis of AIDS/ME/CFS and its subtypes and suggest pathways for the development of diagnostic and therapeutic strategies.

Chronic Fatigue Syndrome has as many variations as African Swine Fever in pigs.

What about the role of HHV-6 in the "Increased Risk of Chronic Multisymptom Illness in Spouses of Gulf War Era Veterans"?

Increased Risk of Chronic Multisymptom Illness in Spouses of Gulf War Era Veterans.

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