Peter Duesberg's heroic warnings about AZT discussed by Perplexity

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 Peter Duesberg can be seen as a hero for warning about AZT because he vocally opposed its widespread use at a time when few scientists were willing to criticize mainstream AIDS policy. Duesberg courageously raised alarms about AZT’s severe toxicity, its approval based on limited and short-term data, and the lack of proven benefit for long-term AIDS survival.


Early and Persistent Warnings

Duesberg was one of the first molecular biologists to point out that AZT, a failed cancer chemotherapy agent, was highly toxic and could damage the immune system even further in patients already struggling with AIDS.


He argued that fast-tracking AZT without sufficient safety data put thousands at risk of early death or severe side effects, a concern later validated by patient experiences and scientific reviews.


Willingness to Challenge Orthodoxy

Speaking against AZT in the late 1980s required extraordinary courage, as the drug was hailed as a “lifesaving breakthrough” by many leading scientists, AIDS activists, and media outlets; public dissent drew intense vilification.


Duesberg’s position led to professional isolation and scorn, yet he maintained his stance on the need for thorough drug safety assessment, reflecting a commitment to scientific integrity over personal or professional gain.


Lasting Impact on Patient Safety

Over time, much of what Duesberg predicted about AZT’s serious side effects and its limits as a monotherapy was borne out, as patients endured anemia, muscle wasting, organ damage, and diminished survival—leading to the eventual abandonment of high-dose AZT and a move to combination therapies.


By questioning both the scientific and ethical grounds for AZT’s approval and aggressive marketing, Duesberg offered an early voice for the patients who suffered from preventable harms and contributed to a necessary reevaluation of AIDS drug policy.


Peter Duesberg’s advocacy represents the ideals of scientific skepticism and patient-centered medicine, emphasizing that real heroism sometimes means challenging consensus and protecting public safety, even at great personal cost.

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