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Wednesday, April 08, 2020

Democratic politician attributes her survival to drug Trump touted.



https://www.abc12.com/content/news/Democratic-state-rep-explains-why-she-opted-for-unproven-COVID-19-treatment-not-hospital-569461601.html

Could a simple blood test for COVID-19 antibodies help reopen the economy?



https://abcnews.go.com/Politics/simple-blood-test-covid-19-antibodies-reopen-economy/story?id=70024837

Hypothesis: Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win todays battle against COVID-19?


Derwand R, MD and Scholz M, PhD

"Currently, drug repurposing is an alternative to novel drug development for the treatment of COVID-19 patients. The antimalarial drug chloroquine (CQ) and its metabolite hydroxychloroquine (HCQ) are currently being tested in several clinical studies as potential candidates to limit SARS-CoV-2-mediated morbidity and mortality. CQ and HCQ (CQ/HCQ) inhibit pH-dependent steps of SARS-CoV-2 replication by increasing pH in intracellular vesicles and interfere with virus particle delivery into host cells. Besides direct antiviral effects, CQ/HCQ specifically target extracellular zinc to intracellular lysosomes where it interferes with RNA-dependent RNA polymerase activity and coronavirus replication. As zinc deficiency frequently occurs in elderly patients and in those with cardiovascular disease, chronic pulmonary disease, or diabetes, we hypothesize that CQ/HCQ plus zinc supplementation may be more effective in reducing COVID-19 morbidity and mortality than CQ or HCQ in monotherapy. Therefore, CQ/HCQ in combination with zinc should be considered as additional study arm for COVID-19 clinical trials."
Source

https://www.preprints.org/manuscript/202004.0124/v1


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